Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Eric S. Diffenderfer"'
Autor:
Wei Zou, Haram Kim, Eric S. Diffenderfer, David J. Carlson, Cameron J. Koch, Ying Xiao, BoonKeng K. Teo, Michele M. Kim, James M. Metz, Yi Fan, Amit Maity, Costas Koumenis, Theresa M. Busch, Rodney Wiersma, Keith A. Cengel, Lei Dong
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionRadiation-induced oxygen depletion in tissue is assumed as a contributor to the FLASH sparing effects. In this study, we simulated the heterogeneous oxygen depletion in the tissue surrounding the vessels and calculated the proton FLASH ef
Externí odkaz:
https://doaj.org/article/88f8009ae1c04021a5a855275fbbc650
Autor:
Tatiana A. Karakasheva, Joel T. Gabre, Uma M. Sachdeva, Ricardo Cruz-Acuña, Eric W. Lin, Maureen DeMarshall, Gary W. Falk, Gregory G. Ginsberg, Zhaohai Yang, Michele M. Kim, Eric S. Diffenderfer, Jason R. Pitarresi, Jinyang Li, Amanda B. Muir, Kathryn E. Hamilton, Hiroshi Nakagawa, Adam J. Bass, Anil K. Rustgi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract 3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created from treatment-naive patient biopsies for prediction of clinical outcomes in patient
Externí odkaz:
https://doaj.org/article/43bca536a467471b9f4d262b3322f68e
Autor:
José Marcio Luna, Hann-Hsiang Chao, Russel T. Shinohara, Lyle H. Ungar, Keith A. Cengel, Daniel A. Pryma, Chidambaram Chinniah, Abigail T. Berman, Sharyn I. Katz, Despina Kontos, Charles B. Simone, II, Eric S. Diffenderfer
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 22, Iss , Pp 69-75 (2020)
Background and Purpose: Radiation esophagitis is a clinically important toxicity seen with treatment for locally-advanced non-small cell lung cancer. There is considerable disagreement among prior studies in identifying predictors of radiation esopha
Externí odkaz:
https://doaj.org/article/4f9a3c1e3a2d4d608c79d2cf6344e73b
Autor:
José Marcio Luna, Andrew R. Barsky, Russell T. Shinohara, Leonid Roshkovan, Michelle Hershman, Alexandra D. Dreyfuss, Hannah Horng, Carolyn Lou, Peter B. Noël, Keith A. Cengel, Sharyn Katz, Eric S. Diffenderfer, Despina Kontos
Publikováno v:
Cancers, Vol 14, Iss 3, p 700 (2022)
We evaluate radiomic phenotypes derived from CT scans as early predictors of overall survival (OS) after chemoradiation in stage III primary lung adenocarcinoma. We retrospectively analyzed 110 thoracic CT scans acquired between April 2012−October
Externí odkaz:
https://doaj.org/article/120253f9afa14044bf44429ba854c4d3
Autor:
Michele M. Kim, Ioannis I. Verginadis, Denisa Goia, Allison Haertter, Khayrullo Shoniyozov, Wei Zou, Amit Maity, Theresa M. Busch, James M. Metz, Keith A. Cengel, Lei Dong, Costas Koumenis, Eric S. Diffenderfer
Publikováno v:
Cancers, Vol 13, Iss 16, p 4244 (2021)
Ultra-high dose rate FLASH proton radiotherapy (F-PRT) has been shown to reduce normal tissue toxicity compared to standard dose rate proton radiotherapy (S-PRT) in experiments using the entrance portion of the proton depth dose profile, while proton
Externí odkaz:
https://doaj.org/article/6d76eaea14fc4778aca887a2606d8269
Autor:
Wei Zou, Rongxiao Zhang, Emil Schueler, Paige A Taylor, Anthony E Mascia, Eric S Diffenderfer, Tianyu Zhao, Ahmet S Ayan, Manju Sharma, Shu-Jung Yu, Weiguo Lu, Walter R Bosch, Christina Tsien, Murat Surucu, Julianne M Pollard-Larkin, Jan Schuemann, Eduardo G Moros, Magdalena Bazalova-Carter, David J Gladstone, Heng Li, Charles B Simone, Kristoffer Petersson, Stephen F Kry, Amit Maity, Billy W Loo, Lei Dong, Peter G Maxim, Ying Xiao, Jeffrey C Buchsbaum
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics.
Publikováno v:
Diffenderfer, E S, Sørensen, B S, Mazal, A & Carlson, D J 2022, ' The current status of preclinical proton FLASH radiation and future directions ', Medical Physics, vol. 49, no. 3, pp. 2039-2054 . https://doi.org/10.1002/mp.15276
We review the current status of proton FLASH experimental systems, including preclinical physical and biological results. Technological limitations on preclinical investigation of FLASH biological mechanisms and determination of clinically relevant p
Autor:
Eric W. Lin, Michele M. Kim, Uma M. Sachdeva, Hiroshi Nakagawa, Maureen DeMarshall, Gary W. Falk, Eric S. Diffenderfer, Anil K. Rustgi, Gregory G. Ginsberg, Jason R. Pitarresi, Tatiana A. Karakasheva, Ricardo Cruz-Acuna, Jinyang Li, Amanda B. Muir, Joel Gabre, Adam J. Bass, Kathryn E. Hamilton, Zhaohai Yang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created from treatment-naive patient biopsies for prediction of clinical outcomes in patients with es
Autor:
Lei Dong, Boon-Keng Kevin Teo, Constantinos Koumenis, Stephen Avery, Keith A. Cengel, Kan Ota, Yongliang Cai, Alexander Lin, David J. Carlson, Paul Boisseau, James M. Metz, Rodney D. Wiersma, Eric S. Diffenderfer, Michele M. Kim, Wei Zou
Publikováno v:
Medical Physics. 48:3948-3957
Introduction Ultra-high dose rate (FLASH) radiotherapy has become a popular research topic with the potential to reduce normal tissue toxicities without losing the benefit of tumor control. The development of FLASH proton pencil beam scanning (PBS) d
Autor:
Rodney D. Wiersma, Theresa M. Busch, Eric S. Diffenderfer, Paul Boisseu, Yi Fan, David J. Carlson, Yongliang Cai, Costas Koumenis, Steve Avery, Michele M. Kim, Alexander Lin, Wei Zou, Lingshu Yin, Kan Ota, James M. Metz, Keith A. Cengel, Lei Dong, Boon-Keng Kevin Teo, Joshua Konzer
Publikováno v:
Radiotherapy and Oncology. 155:212-218
Purpose Proton Pencil Beam Scanning (PBS) is an attractive solution to realize the advantageous normal tissue sparing elucidated from FLASH high dose rates. The mechanics of PBS spot delivery will impose limitations on the effective field dose rate f