Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Eric S Silverman"'
Publikováno v:
BMJ Case Rep
A 36-year-old woman came to emergency room for the complaint of acute onset pain in abdomen radiating to back l last 1 day. Medical history was significant for alcohol and substance use disorder with last binge alcohol drinking 12 hours prior to her
Autor:
Ross Lazarus, Brent Richter, Barbara J. Klanderman, Thomas J. Mariani, Jingsong Xu, Scott T. Weiss, Kelan G. Tantisira, Eric S. Silverman, Augusto A. Litonjua, Lanny J. Rosenwasser, Anne L. Fuhlbrigge
Publikováno v:
Journal of Allergy and Clinical Immunology. 120:1285-1291
Although inhaled corticosteroids (ICSs) generally protect against severe exacerbations in asthma, they may result in elevated IgE levels, which are associated with exacerbations.To determine whether variation in the low-affinity IgE receptor gene, FC
Publikováno v:
The Journal of Immunology. 175:4292-4300
We tested the potential of CpG oligodeoxynucleotides (ODN) to reverse the increased susceptibility to allergic airways disease in neonatal mice in a model of maternal transmission of asthma risk. Offspring of OVA-sensitized and challenged BALB/c moth
Autor:
Lesley Flynt, Venkat Subramaniam, Matthew Mellema, Joseph P. Mizgerd, Paul E. Moore, Débora S. Faffe, Amy Imrich, Timothy A. Whitehead, Matthew R. Jones, Stephanie A. Shore, Eric S. Silverman, Reynold A. Panettieri
Publikováno v:
Journal of Allergy and Clinical Immunology. 115:514-520
Background Eotaxin is implicated in asthmatic eosinophilia. Oncostatin M (OSM) causes eotaxin release from fibroblasts. Objective We sought to examine the effects and mechanism of action of OSM and other IL-6 family cytokines on eotaxin release from
Autor:
Jeffrey M. Drazen, George T. De Sanctis, Lester Kobzik, Venkat Subramaniam, Stephanie A. Shore, Joseph Vallone, Shoji Okinaga, Josephine Hjoberg, Eric S. Silverman, Jack A. Elias, Arlene Hallock
Publikováno v:
Journal of Applied Physiology. 97:249-259
Individuals with asthma have increased levels of nitric oxide in their exhaled air. To explore its role, we have developed a regulatable transgenic mouse capable of overexpressing inducible nitric oxide synthase in a lung-specific fashion. The CC10-r
Autor:
Josephine Hjoberg, Louis Le, Joseph Vallone, Venkat Subramaniam, Sheeba Mathew, Francis H. Y. Green, Kathleen J. Haley, Amy Imrich, Stephanie A. Shore, Eric S. Silverman
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L817-L825
Platelet-derived growth factors (PDGF) may contribute to the activation and growth of smooth muscle that is characteristic of airway remodeling in asthmatic patients. Early growth response 1 (EGR-1) is a transcription factor that is induced in severa
Autor:
Paul E. Moore, Reynold A. Panettieri, Simonetta Baraldo, Deborah S. Faffe, Timothy A. Whitehead, Matthew D. McKenna, Eric S. Silverman, Stephanie A. Shore
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 284:L1093-L1102
Interleukin (IL)-9 is a pleiotropic cytokine that has been proposed as a candidate gene for asthma. As IL-9 expression is correlated with airway hyperresponsiveness in animals, we examined the effects of IL-9 on cultured human airway smooth muscle (H
Autor:
Hartmut Grasemann, Karin Storm van's Gravesande, Jeffrey M. Drazen, Felix Ratjen, Nicola Knauer, Lyle J. Palmer, Rainer Büscher, Eric S. Silverman
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 167:390-394
Variants in the genes encoding for the nitric oxide synthases may act as disease modifier loci in cystic fibrosis, affecting both an individual's nitric oxide level and pulmonary function. In this study, the 894G/T variant in exon 7 of the endothelia
Autor:
Eugene J. Mark, Eric S. Silverman
Publikováno v:
New England Journal of Medicine. 347:1693-1701
Presentation of Case A 32-year-old man was admitted to the hospital because of long-standing hemoptysis and interstitial pulmonary disease. The patient had been born of a 32-week gestation that was complicated by spotting during the first trimester a
Autor:
Jeffrey M. Drazen, Eric S. Silverman, Brian W. Morse, Craig M. Lilly, Hiroshi Inoue, Toshiki Shikanai
Publikováno v:
Journal of Applied Physiology. 93:37-41
There is a relationship between IgE levels and expression of high-affinity IgE receptors (FcεRI). Because the alpha chain is the only portion of the receptor that binds directly to IgE, we reasoned that sequence variants in the FcεRI alpha gene may