Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Eric S Peeples"'
Autor:
Thiago C. Genaro-Mattos, Zeljka Korade, Namood-e Sahar, Jose Pedro Friedmann Angeli, Károly Mirnics, Eric S. Peeples
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Neonatal hypoxic-ischemic brain injury (HIBI) results in part from excess reactive oxygen species and iron-dependent lipid peroxidation (i.e. ferroptosis). The vitamin D precursor 7-dehydrocholesterol (7-DHC) may inhibit iron-dependent lipid
Externí odkaz:
https://doaj.org/article/663ea1161d9047ec88b4bd932d98b045
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 410 (2024)
Cholesterol is an essential molecule of life, and its synthesis can be inhibited by both genetic and nongenetic mechanisms. Hundreds of chemicals that we are exposed to in our daily lives can alter sterol biosynthesis. These also encompass various cl
Externí odkaz:
https://doaj.org/article/517b6a0851d84a83bb1128a78706c3e1
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: MicroRNAs (miRNAs) may be promising therapeutic targets for neonatal hypoxic-ischemic brain injury (HIBI) but targeting miRNA-based therapy will require more precise understanding of endogenous brain miRNA expression.Methods: Postnatal da
Externí odkaz:
https://doaj.org/article/3cedae2584a84dc784965b1a20193a3d
Publikováno v:
Metabolites, Vol 12, Iss 5, p 467 (2022)
Hypoxic-ischemic brain injury (HIBI) leads to depletion of ATP, mitochondrial dysfunction, and enhanced oxidant formation. Measurement of acylcarnitines may provide insight into mitochondrial dysfunction. Plasma acylcarnitine levels are altered in ne
Externí odkaz:
https://doaj.org/article/21a7b54ab7394659a1ff8ca070665ee0
Neuronal-derived extracellular vesicles are enriched in the brain and serum of HIV-1 transgenic rats
Autor:
Raghubendra Singh Dagur, Ke Liao, Susmita Sil, Fang Niu, Zhiqiang Sun, Yuri L. Lyubchenko, Eric S. Peeples, Guoku Hu, Shilpa Buch
Publikováno v:
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Despite the efficacy of combination antiretroviral therapy (ART) in controlling human immunodeficiency virus (HIV-1) replication, cytotoxic viral proteins such as HIV-1 transactivator of transcription (Tat) persist in tissues such as the brain. Altho
Externí odkaz:
https://doaj.org/article/4661673929ae45c685a40041f0095a1c
Autor:
Stephanie M Parry, Eric S Peeples
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 7, Pp 1125-1135 (2018)
Neonatal hypoxic-ischemic encephalopathy continues to be a significant cause of death or neurodevelopmental delays despite standard use of therapeutic hypothermia. The use of stem cell transplantation has recently emerged as a promising supplemental
Externí odkaz:
https://doaj.org/article/c0d82f2a73c34a008afcddd67bb3b71f
Autor:
Eric S. Peeples
Publikováno v:
Pediatric Research. 93:780-788
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8229257558c3f544704f2418f5d8df56
https://doi.org/10.1038/s41390-022-02196-4
https://doi.org/10.1038/s41390-022-02196-4
Autor:
Naseer A. Kutchy, Eric S. Peeples, Susmita Sil, Ke Liao, Ernest T. Chivero, Guoku Hu, Shilpa Buch
Publikováno v:
Viruses, Vol 12, Iss 7, p 700 (2020)
Almost all types of cells release extracellular vesicles (EVs) into the extracellular space. EVs such as exosomes and microvesicles are membrane-bound vesicles ranging in size from 30 to 1000 nm in diameter. Under normal conditions, EVs mediate cell
Externí odkaz:
https://doaj.org/article/5366de901fd345958a8a80c4441dbe48
Autor:
Eric S. Peeples, Jeffrey W. Kepple
Publikováno v:
American Journal of Medical Genetics Part A. 188:548-555
Trisomy 13 and 18 are common chromosomal abnormalities that affect multiple organ systems. There is a paucity of published data, however, on the hepatic complications seen in these patient populations. One of the most common pathologic hepatobiliary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30842069b9fa476456ebc21961b1b74e
https://doi.org/10.1002/ajmg.a.62552
https://doi.org/10.1002/ajmg.a.62552
Publikováno v:
Pediatr Res
Neonatal hypoxic-ischemic brain injury (HIBI) results in significant morbidity and mortality despite current standard therapies. MicroRNAs (miRNAs) are a promising therapeutic target; however, there is a paucity of data on endogenous miRNA expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfabde930f429596cfbb6198bd4dc18
https://doi.org/10.1038/s41390-021-01701-5
https://doi.org/10.1038/s41390-021-01701-5