Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Eric Ring"'
Autor:
Theodore S. Johnson, Rafal Pacholczyk, Zuzana Berrong, Chenbin Huang, Eugene P. Kennedy, Eric Ring, Ramses F. Sadek, Sarthak Satpathy, Beena E. Thomas, Tobey J. MacDonald, Manoj Bhasin, David H. Munn
Publikováno v:
Cancer Research. 83:LB200-LB200
Increasing evidence suggests that many of the effector CD8+ T cells reactivated (‘rejuvenated”) by immunotherapy come from outside the tumor, derived from a circulating pool of “stem-like” memory or “precursor-exhausted” (TPEX) cells. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73df14c45343473f96aaf505b7373135
https://doi.org/10.1158/1538-7445.am2023-lb200
https://doi.org/10.1158/1538-7445.am2023-lb200
Autor:
Theodore Johnson, Rafal Pacholczyk, Dolly Aguilera, Ahmad Al-Basheer, Manish Bajaj, Pratiti Bandopadhayay, Zuzana Berrong, Eric Bouffet, Robert Castellino, Kathleen Dorris, Bree Eaton, Natia Esiashvili, Nicholas Foreman, Diana Fridlyand, Cole Giller, Ian Heger, Nadja Kadom, Eugene Kennedy, Neevika Manoharan, William Martin, Colleen McDonough, Rebecca Parker, Vijay Ramaswamy, Eric Ring, Amyn Rojiani, Ramses Sadek, Amy Smith, Chris Smith, Rachel Vaizer, Kee Kiat Yeo, Tobey MacDonald, David Munn
Publikováno v:
Neuro-Oncology. 24:vii68-vii68
BACKGROUND Recurrent brain tumors are the leading cause of cancer death in children. We conducted a first-in-children, two-institution, Phase 1 open-label dose-confirmation study using a 3 + 3 design, with expansion cohorts, to determine the recommen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab01c9865aca474900034e328e975d64
https://doi.org/10.1093/neuonc/noac209.264
https://doi.org/10.1093/neuonc/noac209.264
Autor:
Catherine P. Langford, G. Yancey Gillespie, Xiaosi Han, Dongquan Chen, Gregory K. Friedman, Samantha Youngblood, Joshua D. Bernstock, James M. Markert, Li Nan, Blake P. Moore, Elizabeth A. Beierle, Eric Ring, Virginia M. Kelly
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Pediatric high-grade brain tumors and adult glioblastoma are associated with significant morbidity and mortality. Oncolytic herpes simplex virus-1 (oHSV) is a promising approach to target brain tumors; oHSV G207 and M032 (encodes human interleukin-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9664b371a4ee1c0d1503a68dacc07f85
http://link.springer.com/article/10.1038/s41598-018-32353-x
http://link.springer.com/article/10.1038/s41598-018-32353-x
Autor:
Ian M Heger, Tobey J. MacDonald, Dolly Aguilera, Eric Ring, Robert C. Castellino, Amy Smith, David H. Munn, Bree R. Eaton, A. Al-Basheer, Christopher Smith, Eugene P. Kennedy, Natia Esiashvili, Zuzana Berrong, Rachel P. Vaizer, Ramses F. Sadek, Theodore S. Johnson, Nicholas K. Foreman, W. Martin, Rafal Pacholczyk, Manish Bajaj
Publikováno v:
Neuro-Oncology. 23:i27-i27
Background Diffuse intrinsic pontine glioma (DIPG) is a uniformly fatal brain tumor with no available cure. Indoximod blocks the IDO (indoleamine 2,3-dioxygenase) pathway, thereby reversing IDO-mediated immune suppression in the tumor microenvironmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa04472d0acdd28dd16be05366fe961
https://doi.org/10.1093/neuonc/noab090.112
https://doi.org/10.1093/neuonc/noab090.112
Autor:
Xiaosi Han, Gregory K. Friedman, Rong Li, Blake P. Moore, Li Nan, Virginia M. Kelly, James M. Markert, Eric Ring, Jianmei W. Leavenworth, G. Yancey Gillespie, Elizabeth A. Beierle
Publikováno v:
Molecular Therapy Oncolytics
Molecular Therapy: Oncolytics, Vol 7, Iss, Pp 27-36 (2017)
Molecular Therapy: Oncolytics, Vol 7, Iss, Pp 27-36 (2017)
Despite advances in conventional chemotherapy, surgical techniques, and radiation, outcomes for patients with relapsed, refractory, or metastatic soft tissue sarcomas are dismal. Survivors often suffer from lasting morbidity from current treatments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e3cfd589e3d220bf3377e6b2c1444a
http://europepmc.org/articles/PMC5633864
http://europepmc.org/articles/PMC5633864
Publikováno v:
Oncolytic Virotherapy
Pediatric solid tumors remain a major health concern, with nearly 16,000 children diagnosed each year. Of those, ~2,000 succumb to their disease, and survivors often suffer from lifelong disability secondary to toxic effects of current treatments. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6bef1d211a140a5e43fd0a9be1461e
https://doi.org/10.2147/ov.s96932
https://doi.org/10.2147/ov.s96932
Autor:
Bree R. Eaton, Amy Smith, Natia Esiashvili, N. Vahanian, Tobey J. MacDonald, Nicholas K. Foreman, Rafal Pacholczyk, W. Martin, Ramses F. Sadek, A. Al-Basheer, Theodore S. Johnson, Eric Ring, Ian M Heger, E.P. Kennedy, Dolly Aguilera, Michiko Shimoda, David H. Munn, Robert C. Castellino, Zuzana Berrong
Publikováno v:
Annals of Oncology. 30:xi38
Background We conducted a phase Ib dose-confirmation study of indoximod with radiation, followed by indoximod with cyclic temozolomide therapy, to evaluate safety and overall survival (OS) in children with newly diagnosed DIPG (diffuse intrinsic pont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::316e7da67a6e6d0dcd3769f8dcf858b9
https://doi.org/10.1093/annonc/mdz451.010
https://doi.org/10.1093/annonc/mdz451.010
Autor:
Amy Smith, Dolly Aguilera, Ramses F. Sadek, Theodore S. Johnson, Ian M. Heger, Eugene P. Kennedy, Eric Ring, Nicholas N. Vahanian, Bree R. Eaton, Craig Castellino, Nicholas K. Foreman, Charles J. Link, W. Martin, A. Al-Basheer, David H. Munn, Natia Esiashvili, Tobey J. MacDonald
BACKGROUND: Indoximod is an IDO pathway inhibitor with a differentiated mechanism of action directly targeting immune cells to reverse the immune suppression generated by tumors. An ongoing phase-1b/2a study (NCT02502708) using indoximod in combinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df92f4edc44e262141a0061037d56a4b
https://europepmc.org/articles/PMC6012944/
https://europepmc.org/articles/PMC6012944/
Pediatric brain and extracranial solid tumors are a diverse group of malignancies that represent almost half of all pediatric cancers. Standard therapy includes various combinations of surgery, cytotoxic chemotherapy, and radiation, which can be very
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ebdcb099ff907809e2fc81df661d04
https://europepmc.org/articles/PMC5241220/
https://europepmc.org/articles/PMC5241220/
Autor:
Gregory K. Friedman, Eric Ring, Tina Etminan, G. Yancey Gillespie, Li Nan, Blake P. Moore, James M. Markert
PCM-21. EXPRESSION OF IMMUNE CHECKPOINT PROTEINS IN PATIENT-DERIVED PEDIATRIC BRAIN TUMOR XENOGRAFTS Eric Ring, Blake Moore, Li Nan, Tina Etminan, James Markert, G. Yancey Gillespie, and Gregory Friedman; University of Alabama at Birmingham, Birmingh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebdcb19b7615f19d6ff724ed66772eb
https://europepmc.org/articles/PMC4903751/
https://europepmc.org/articles/PMC4903751/