Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Eric Raimbaud"'
Autor:
Jean-Baptiste Garsi, Balázs Komjáti, Gregorio Cullia, Imre Fejes, Melinda Sipos, Zoltán Sipos, Eszter Fördős, Piroska Markacz, Barbara Balázs, Nathalie Lancelot, Sylvie Berger, Eric Raimbaud, David Brown, Laurent-Michel Vuillard, Laure Haberkorn, Cyprian Cukier, Zoltán Szlávik, Stephen Hanessian
Publikováno v:
ACS medicinal chemistry letters, vol 13, iss 6
ACS Med Chem Lett
ACS Med Chem Lett
[Image: see text] On the basis of the knowledge that the proline-rich hot spot PPPRPP region of P(151)PSNPPPRPP(160), an oligopeptide derived from the cytosolic portion of p22(phox) (p22), binds to the single functional bis-SH3 domain of the regulato
Autor:
Timea Balo, Attila Sapi, Arpad Kiss, Eric Raimbaud, Jérome Paysant, Marie-Elodie Cattin, Sylvie Berger, Andras Kotschy, Nicolas Faucher
Publikováno v:
Monatshefte für Chemie - Chemical Monthly.
Autor:
Marie-Odile Vallez, Elisabeth Ruano, Philippe Mennecier, Nicole Despaux, Thierry Persigand, Patrice Desos, Philippe Gloanec, Alain Rupin, Eric Raimbaud, Patricia Sansilvestri-Morel, Schaffner Arnaud-Pierre
Publikováno v:
Journal of medicinal chemistry. 64(7)
Selective and potent inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) have the potential to increase endogenous and therapeutic fibrinolysis and to behave like profibrinolytic agents without the risk of major hemorrhage, si
Autor:
Thierry Le Diguarher, Eric Raimbaud, Patrick Casara, Marc Bertrand, Massimo Sabatini, Nicolas Guilbaud, Alain Pierre, Anne-Marie Chollet, Gordon C. Tucker, Philippe Hennig
Publikováno v:
Journal of Medicinal Chemistry. 46:3840-3852
The synthesis and structure-activity relationship (SAR) studies of a series of cyclopentane carboxylic acid matrix metalloproteinase (MMP) inhibitors are described. Potent and specific MMP-2, -3, -9, -13 inhibitors were obtained by regio- and stereos
Autor:
Eric Raimbaud, Pierre Renard, Jean-Pierre Gesson, Bruno Pfeiffer, Delphine Quintard, Philippe Bertrand, Sophie Vielle
Publikováno v:
Synlett. :2033-2036
A short and convergent synthesis of a 10-oxa epothilone analog is based on aldolisation of a β-methallyloxy aldehyde derived from methyl 3-hydroxy-2S-methyl propionate followed by ring-closing metathesis.
Autor:
Delphine Quintard, Pierre Renard, Philippe Bertrand, Bruno Pfeiffer, Sophie Vielle, Eric Raimbaud, Jean-Pierre Gesson
Publikováno v:
Tetrahedron Letters. 43:9213-9216
Starting from the X-ray structure of epothilone B, an original, non macrocyclic, structure has been designed to mimic the key structural features of this potent anticancer agent; the preparation of a key intermediate incorporating four stereogenic ce
Autor:
Jean-Luc Fauchère, André Michel, Sophie Ollivier, Eric Raimbaud, Edgar Jacoby, Michael Spedding
Publikováno v:
Quantitative Structure-Activity Relationships. 18:561-572
Three-dimensional models of ligand-receptor complexes based on site-directed mutagenesis experiments of the monoamine G protein-coupled receptors reveal the existence of three distinct drug binding sites inside the receptors. Here, we develop this
Autor:
Giulia Caron, Cécile Bussey, Jean-Michel Scherrmann, Bernard Walther, Pierre Got, Pierre-Alain Carrupt, Eric Raimbaud, Armand Bensussan
Publikováno v:
Pharmaceutical Research. 16:725-735
Purpose. An immunoconjugate model was proposed to produce stereo-selective monoclonal antibodies (MAbs) for the quantitation of a 5-HT1A agonist, S 20499. MAbs produced were characterized in terms of stereoselectivity and specificity towards the oppo
Autor:
Michel Félétou, Christophe Thurieau, Eric Raimbaud, Philippe Hennig, Emmanuel Canet, Jean-Luc Fauchère
Publikováno v:
Journal of Medicinal Chemistry. 39:2095-2101
We report here on the synthesis and pharmacological properties of a new series of small linear and cyclic peptides derived from the five C-terminal amino acid residues of second-generation bradykinin receptor antagonists. Variations of the two first
Publikováno v:
Carbohydrate Research. 227:351-363
Acarbose and its homologs inhibit alpha-D-glucosidases, particularly alpha-amylases. These homologs have the same core, the pseudo-disaccharide acarviosine, linked to various numbers of glucose residues. The conformations of (R)- and (S)-acarviosine