Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Eric Raabe"'
Autor:
Keisuke Katsushima, Rudramani Pokhrel, Iqbal Mahmud, Menglang Yuan, Rabi Murad, Prabin Baral, Rui Zhou, Prem Chapagain, Timothy Garrett, Stacie Stapleton, George Jallo, Chetan Bettegowda, Eric Raabe, Robert J. Wechsler-Reya, Charles G. Eberhart, Ranjan J. Perera
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Medulloblastoma (MB) develops through various genetic, epigenetic, and non-coding (nc) RNA-related mechanisms, but the roles played by ncRNAs, particularly circular RNAs (circRNAs), remain poorly defined. CircRNAs are increasingly recognized
Externí odkaz:
https://doaj.org/article/189686aa08f2466da897e79be7e129e1
Autor:
Jena V. Lilly, Jo Lynne Rokita, Jennifer L. Mason, Tatiana Patton, Stephanie Stefankiewiz, David Higgins, Gerri Trooskin, Carina A. Larouci, Kamnaa Arya, Elizabeth Appert, Allison P. Heath, Yuankun Zhu, Miguel A. Brown, Bo Zhang, Bailey K. Farrow, Shannon Robins, Allison M. Morgan, Thinh Q. Nguyen, Elizabeth Frenkel, Kaitlin Lehmann, Emily Drake, Catherine Sullivan, Alexa Plisiewicz, Noel Coleman, Luke Patterson, Mateusz Koptyra, Zeinab Helili, Nicholas Van Kuren, Nathan Young, Meen Chul Kim, Christopher Friedman, Alex Lubneuski, Christopher Blackden, Marti Williams, Valerie Baubet, Lamiya Tauhid, Jamie Galanaugh, Katie Boucher, Heba Ijaz, Kristina A. Cole, Namrata Choudhari, Mariarita Santi, Robert W. Moulder, Jonathan Waller, Whitney Rife, Sharon J. Diskin, Marion Mateos, Donald W. Parsons, Ian F. Pollack, Stewart Goldman, Sarah Leary, Chiara Caporalini, Anna Maria Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Ron Firestein, Jason Cain, Joanna J. Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey P. Greenfield, Rintaro Hashizume, Amy Smith, Shida Zhu, James M. Johnston, Jason R. Fangusaro, Matthew Miller, Matthew D. Wood, Sharon Gardner, Claire L. Carter, Laura M. Prolo, Jared Pisapia, Katherine Pehlivan, Andrea Franson, Toba Niazi, Josh Rubin, Mohamed Abdelbaki, David S. Ziegler, Holly B. Lindsay, Ana Guerreiro Stucklin, Nicolas Gerber, Olena M. Vaske, Carolyn Quinsey, Brian R. Rood, Javad Nazarian, Eric Raabe, Eric M. Jackson, Stacie Stapleton, Robert M. Lober, David E. Kram, Carl Koschmann, Phillip B. Storm, Rishi R. Lulla, Michael Prados, Adam C. Resnick, Angela J. Waanders
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 35, Iss , Pp 100846- (2023)
Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term
Externí odkaz:
https://doaj.org/article/ccba034296a747dd98510c07ca0814c3
Autor:
Naiara Martínez-Vélez, Marc Garcia-Moure, Miguel Marigil, Marisol González-Huarriz, Montse Puigdelloses, Jaime Gallego Pérez-Larraya, Marta Zalacaín, Lucía Marrodán, Maider Varela-Guruceaga, Virginia Laspidea, Jose Javier Aristu, Luis Isaac Ramos, Sonia Tejada-Solís, Ricardo Díez-Valle, Chris Jones, Alan Mackay, Jose A. Martínez-Climent, Maria Jose García-Barchino, Eric Raabe, Michelle Monje, Oren J. Becher, Marie Pierre Junier, Elias A. El-Habr, Herve Chneiweiss, Guillermo Aldave, Hong Jiang, Juan Fueyo, Ana Patiño-García, Candelaria Gomez-Manzano, Marta M. Alonso
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The oncolytic virus Delta-24-RGD is in clinical trial for adult glioma. Here, the authors show that this virus elicits an immune response in mouse models of pediatric high-grade glioma and diffuse pontine intrinsic glioma, resulting in improved survi
Externí odkaz:
https://doaj.org/article/e70b68b3d2c14bafb5f5185c1fba26c6
Autor:
Saritha Tantravedi, Farhad Vesuna, Paul T. Winnard, Jr., Allison Martin, Michael Lim, Charles G. Eberhart, Cynthia Berlinicke, Eric Raabe, Paul J. van Diest, Venu Raman
Publikováno v:
Translational Oncology, Vol 12, Iss 1, Pp 96-105 (2019)
Medulloblastoma is the most common malignant tumor that arises from the cerebellum of the central nervous system. Clinically, medulloblastomas are treated by surgery, radiation, and chemotherapy, all of which result in toxicity and morbidity. Recent
Externí odkaz:
https://doaj.org/article/d6b70f7db6ee4f89a55ae33c6c6dc599
Autor:
Ryan J. Duchatel, Evangeline R. Jackson, Sarah G. Parackal, Claire Sun, Paul Daniel, Abdul Mannan, Izac J. Findlay, Dilana Staudt, Zacary P. Germon, Sandra Laternser, Dylan Kiltschewskij, Padraic S. Kearney, M. Fairuz, B. Jamaluddin, Alicia M. Douglas, Tyrone Beitaki, Mika Persson, Elizabeth E. Manning, Heather C. Murray, Nicole M. Verrills, David A. Skerrett-Byrne, Brett Nixon, Susan Hua, Valdes-Mora Fatima, Maria Tsoli, David S. Ziegler, Murray J. Cairns, Eric Raabe, Nicholas A. Vitanza, Carl Koschmann, Frank Alvaro, Christopher V. Dayas, Christopher L. Tinkle, David D. Eisenstat, Ron Firestein, Sabine Mueller, Javad Nazarian, Jason E. Cain, Matthew D. Dun
Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma – DIPG), are uniformly fatal brain tumors that lack effective pharmacological treatment. Analysis of pooled CRISPR-Cas9 loss-of-function gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7761ac079918d3d90d3ed9557966419d
https://doi.org/10.1101/2023.04.17.537256
https://doi.org/10.1101/2023.04.17.537256
Autor:
Menglang Yuan, Keisuke Katsushima, Rudramani Pokhrel, Bongyong Lee, Stacie Stapleton, George Jallo, Eric Raabe, Charles Eberhart, Ranjan Perera
Publikováno v:
Neuro-Oncology. 24:vii227-vii228
Medulloblastoma is a central nervous system tumor that primarily affects children and requires aggressive therapy. Patients often suffer from treatment-related side effects, and treatment-resistant recurrences are common, with high mortality rates. T
Publikováno v:
Neuro-Oncology. 24:vii212-vii213
Diffuse Intrinsic Pontine Glioma (DIPG) is a pediatric brain tumor characterized by epigenetic dysregulation with median survival of 9-11 months. Currently, radiation is the only therapy option, and therefore calls for a new, effective treatment meth
Publikováno v:
Cancer Research. 83:3414-3414
Pediatric low-grade glioma (pLGG) is the most common childhood brain tumor. Patients with pLGG often have significant lifelong disabilities due to the location of the tumor and tumor treatments, including surgery, chemotherapy, and radiation. The mos
Abstract 1141: The CoREST complex as a novel target to disrupt AT/RT’s abnormal epigenetic landscape
Autor:
Anupa Geethadevi, Marianne Collard, Nikhil Vaidya, Tyler Findlay, Kristen Malebranche, Charles Eberhart, Eric Raabe, Philip Cole, Rhoda Alani, Jeffrey Rubens
Publikováno v:
Cancer Research. 83:1141-1141
Atypical teratoid/rhabdoid tumors (AT/RT) are deadly infantile brain tumors. Their aggressive phenotype results from a single recurring biallelic loss-of-function mutation in genes encoding components of the SWI/SNF chromatin-remodeling complex - SMA
Publikováno v:
Cancer Research. 83:4990-4990
Diffuse midline glioma (DMG) is an aggressive pediatric glioma with no curative treatment options. Mutation in MAPK pathway is common in many DMG tumors, however, has not been largely explored before. E6201 is a dual inhibitor of ACVR1 and MEK 1/2. I