Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Eric R. Lutz"'
Autor:
Takahiro Tsujikawa, Sushil Kumar, Rohan N. Borkar, Vahid Azimi, Guillaume Thibault, Young Hwan Chang, Ariel Balter, Rie Kawashima, Gina Choe, David Sauer, Edward El Rassi, Daniel R. Clayburgh, Molly F. Kulesz-Martin, Eric R. Lutz, Lei Zheng, Elizabeth M. Jaffee, Patrick Leyshock, Adam A. Margolin, Motomi Mori, Joe W. Gray, Paul W. Flint, Lisa M. Coussens
Publikováno v:
Cell Reports, Vol 19, Iss 1, Pp 203-217 (2017)
Here, we describe a multiplexed immunohistochemical platform with computational image processing workflows, including image cytometry, enabling simultaneous evaluation of 12 biomarkers in one formalin-fixed paraffin-embedded tissue section. To valida
Externí odkaz:
https://doaj.org/article/29a7b3ea556a43c78bede944b10a3c6b
Autor:
Lei Zheng, Elizabeth M. Jaffee, Robert A. Anders, Ralph H. Hruban, Jiang Wang, Christopher L. Wolfgang, Daniel Laheru, Allison Yager, Anthony Wamwea, Alvin Dorman, Sara Solt, Kevin Soares, Guanglan Mo, Rajni Sharma, Elaine Bigelow, Annie A. Wu, Eric R. Lutz
Pancreatic ductal adenocarcinoma (PDAC) is considered a “nonimmunogenic” neoplasm. Single-agent immunotherapies have failed to demonstrate significant clinical activity in PDAC and other “nonimmunogenic” tumors, in part due to a complex tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::272951243253fc635c17afbabcf9b858
https://doi.org/10.1158/2326-6066.c.6548425.v1
https://doi.org/10.1158/2326-6066.c.6548425.v1
Autor:
Lei Zheng, Elizabeth M. Jaffee, Robert A. Anders, Ralph H. Hruban, Jiang Wang, Christopher L. Wolfgang, Daniel Laheru, Allison Yager, Anthony Wamwea, Alvin Dorman, Sara Solt, Kevin Soares, Guanglan Mo, Rajni Sharma, Elaine Bigelow, Annie A. Wu, Eric R. Lutz
Figure S1 Schema of the Neoadjuvant and Adjuvant Study of Panc GVAX. Figure S2 Pre- and post-vaccination mesothelin peptide-specific T cell levels in responders versus nonresponders. Figure S3 Intratumoral tertiary lymphoid aggregate in PDACs from pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73b3a7e2bb6ff97dd06f2450b7f14fe
https://doi.org/10.1158/2326-6066.22537381.v1
https://doi.org/10.1158/2326-6066.22537381.v1
Autor:
Brie Chun, Eric R Lutz, Lakshmi Rudraraju, Elizabeth DeOliveira, Amanda Seiz, Monil Shah, Ivan Borrello, Nicole E Fredrich, Kimberly Noonan, David B Page
Publikováno v:
Cancer Research. 82:P2-14
Background: The bone marrow harbors tumor-antigen specific T cells in patients with breast cancer (1). Marrow-infiltrating lymphocytes (MILs®) are the product of activating and expanding bone-marrow T cells (2). In multiple myeloma, transfer of MILs
Autor:
Paul L. Swiecicki, Monil Shah, Eleni Efstatihiou, Nicole Fredrich, Elizabeth DeOliveira, Lakshmi Rudraraju, Beverly Fu, Amanda Seiz, Celine Colmenares, Ivan Borrello, Chad Brenner, Kimberly Noonan, Daniela A. Bota, Collin Brummel, Eric R. Lutz, David B. Page
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Marrow infiltrating lymphocytes (MILsTM) are the product of activating and expanding bone marrow T cells.1 The bone marrow is a specialized niche in the immune system enriched for antigen-experienced, memory T cells. In patients with multi
Publikováno v:
Nature Reviews Cancer. 17:209-222
The past decade of cancer research has been marked by a growing appreciation of the role of immunity in cancer. Mutations in the tumour genome can cause tumours to express mutant proteins that are tumour specific and not expressed on normal cells (ne
Autor:
Elizabeth DeOliveria, Melissa Lynne Johnson, Monil Shah, Ben C. Creelan, Aaron Lisberg, Martin J. Edelman, Eric R. Lutz, Kim Noonan, Amanda Seiz, Lakshmi Rudraraju, Marianna Koczywas
Publikováno v:
Journal of Clinical Oncology. 38:TPS9630-TPS9630
TPS9630 Background: Primary or secondary resistance to anti-PD-1 may be due to loss of T cell function. Persistent antigen stimulation can lead to impaired CD8+ T cell function, which often results in acquired resistance to PD-1 inhibition. It is unc
Autor:
Heather Kinkead, Eric R. Lutz, Todd D. Armstrong, Laura Hix Glickman, Skylar Woolman, Sarah M. McWhirter, Elizabeth M. Jaffee, Chudi Ndubaku, Teena Vithayathil, Alexander Hopkins, Kayla Cruz, Mark Yarchoan, Annie A. Wu, Neeha Zaidi, Thomas W. Dubensky
Tumor neoantigens arising from somatic mutations in the cancer genome are less likely to be subject to central immune tolerance and are therefore attractive targets for vaccine immunotherapy. We utilized whole-exome sequencing, RNA sequencing (RNASeq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6022acc0029b2f197cc945bc1ea62036
https://europepmc.org/articles/PMC6237485/
https://europepmc.org/articles/PMC6237485/
Autor:
Michael Studinger, John Sonntag, Thomas Neumann, Michelle Hofton, Lauren C. Andrews, Robert L. Hawley, Eric R. Lutz, Kelly M. Brunt
Publikováno v:
The Cryosphere, Vol 11, Iss 2, Pp 681-692 (2017)
A series of NASA airborne lidars have been used in support of satellite laser altimetry missions. These airborne laser altimeters have been deployed for satellite instrument development, for spaceborne data validation, and to bridge the data gap betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9642478d9cc524f23acc429296c86b
https://www.the-cryosphere.net/11/681/2017/
https://www.the-cryosphere.net/11/681/2017/
Autor:
Sean Mackay, Elizabeth DeOliveira, Ivan Borrello, Eric R. Lutz, Srikanta Jana, Kimberly Noonan, Jing Zhou, Lakshmi Rudraraju
Publikováno v:
Blood. 134:4437-4437
Background The type of T cell used in generating chimeric antigen receptor (CAR) T cells is an important choice. Evidence suggests that T cells that are early in the effector/memory differentiation pathway with more stemness and greater potential to