Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Eric R. Gremmer"'
Autor:
Christy B. M. Tulen, Evert Duistermaat, Johannes W. J. M. Cremers, Walther N. M. Klerx, Paul H. B. Fokkens, Naömi Weibolt, Nico Kloosterboer, Mieke A. Dentener, Eric R. Gremmer, Phyllis J. J. Jessen, Evi J. C. Koene, Lou Maas, Antoon Opperhuizen, Frederik-Jan van Schooten, Yvonne C. M. Staal, Alexander H. V. Remels
Publikováno v:
Cells, Vol 11, Iss 21, p 3481 (2022)
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease primarily caused by exposure to cigarette smoke (CS). During the pyrolysis and combustion of tobacco, reactive aldehydes such as acetaldehyde, acrolein, and formaldehyde are f
Externí odkaz:
https://doaj.org/article/2858f0d527984676b53f121e83d3e3b9
Autor:
Hedwig M. Braakhuis, Eric R. Gremmer, Anne Bannuscher, Barbara Drasler, Sandeep Keshavan, Barbara Rothen-Rutishauser, Barbara Birk, Andreas Verlohner, Robert Landsiedel, Kirsty Meldrum, Shareen H. Doak, Martin J.D. Clift, Johanna Samulin Erdem, Oda A.H. Foss, Shanbeh Zienolddiny-Narui, Tommaso Serchi, Elisa Moschini, Pamina Weber, Sabina Burla, Pramod Kumar, Otmar Schmid, Edwin Zwart, Jolanda P. Vermeulen, Rob J. Vandebriel
Overall, the results of the 7 participating laboratories are quite similar. After exposing Calu-3 alone and Calu-3 co-cultures with macrophages, no effects of lipopolysaccharide (LPS), quartz (DQ12) or titanium dioxide (TiO2) NM-105 particles on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245bd559325ffda2512c00b83f58e046
http://hdl.handle.net/10029/626726
http://hdl.handle.net/10029/626726
Autor:
Leo T.M. Van Der Ven, Paul Van Ommeren, Edwin P. Zwart, Eric R. Gremmer, Hennie M. Hodemaekers, Harm J. Heusinkveld, Jacob D. van Klaveren, Emiel Rorije
Publikováno v:
Environmental health perspectives. 130(4)
Humans are exposed to combinations of chemicals. In cumulative risk assessment (CRA), regulatory bodies such as the European Food Safety Authority consider dose addition as a default and sufficiently conservative approach. The principle of dose addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496722a8c93f1f98833ae123218ac7e7
https://pubmed.ncbi.nlm.nih.gov/35394809
https://pubmed.ncbi.nlm.nih.gov/35394809
Autor:
Paul Schwillens, Eric R. Gremmer, Louis van Bloois, Wim H. de Jong, Geertsma Re, Peter H. J. Keizers, Christina Giannakou, Kukka Aimonen, Rob J. Vandebriel, Julia Catalán, Margriet V. D. Z. Park
Publikováno v:
Nanomedicine, 14(10), 1231-1246. Future Medicine Ltd.
Aim: Nanomaterials and nanomedicinal products tend to interfere with various commonly used assays, including regulatory required endotoxin detection methods for medicines. We developed a method to quantify endotoxin levels that is compatible with nan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67785743aa8643918419ec411fdc6219
https://doi.org/10.2217/nnm-2018-0339
https://doi.org/10.2217/nnm-2018-0339
Autor:
Rui-Wen, He, Hedwig M, Braakhuis, Rob J, Vandebriel, Yvonne C M, Staal, Eric R, Gremmer, Paul H B, Fokkens, Claudia, Kemp, Jolanda, Vermeulen, Remco H S, Westerink, Flemming R, Cassee
Publikováno v:
Journal of Aerosol Science
Inhalation exposure to environmental and occupational aerosol contaminants is associated with many respiratory health problems. To realistically mimic long-term inhalation exposure for toxicity testing, lung epithelial cells need to maintained and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a39ceb19f68cde1f2b61b408af533d7d
https://pubmed.ncbi.nlm.nih.gov/33658726
https://pubmed.ncbi.nlm.nih.gov/33658726
Autor:
Hilda J I De Jong, Jan G M C Damoiseaux, Rob J Vandebriel, Patrick C Souverein, Eric R Gremmer, Mia Wolfs, Olaf H Klungel, Henk Van Loveren, Jan Willem Cohen Tervaert, W M Monique Verschuren
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77587 (2013)
It has been suggested that statins can both stimulate and suppress the immune system, and thereby, may influence autoimmune diseases. Therefore, we studied effects of statins on innate and adaptive immunity, and self-tolerance by measuring serologica
Externí odkaz:
https://doaj.org/article/124b362cf8ab47bdb8cd1697b02bc1ab
Autor:
Emiel Rorije, Edwin P. Zwart, Evelyn D. Olthof, Hedwig M. Braakhuis, Wout Slob, Mirjam Luijten, Jan van Benthem, Gerrit Wolterink, Ruud Woutersen, Jan Willem van der Laan, Eric R. Gremmer
Publikováno v:
Critical Reviews in Toxicology. 48:500-511
Non-genotoxic carcinogens (NGTXCs) do not cause direct DNA damage but induce cancer via other mechanisms. In risk assessment of chemicals and pharmaceuticals, carcinogenic risks are determined using carcinogenicity studies in rodents. With the aim to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37aa5f02448a20eadd96effface8cf6
https://doi.org/10.1080/10408444.2018.1458818
https://doi.org/10.1080/10408444.2018.1458818
Publikováno v:
European Journal of Nutrition & Food Safety. 8:47-58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09fa747572464690b181dd9bd7e2909b
https://doi.org/10.9734/ejnfs/2018/39438
https://doi.org/10.9734/ejnfs/2018/39438
Autor:
Iseult Lynch, Flemming R. Cassee, Eric R. Gremmer, Susan Dekkers, Tim D. Williams, Emily J. Guggenheim, Mark R. Viant, Shan He, Wim H. de Jong, Rob J. Vandebriel, Liset J.J. de la Fonteyne, Jiarui Zhou, Jinkang Zhang
Publikováno v:
Environmental Science: Nano. 5:1506-1517
The toxicity of silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs) has been associated with their dissolution or ability to release metal ions while the toxicity of cerium dioxide (CeO2) NPs has been related to their ability to induce or reduce oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::031a2475abcfbe570c94ae0e8bea53f9
https://doi.org/10.1039/c8en00071a
https://doi.org/10.1039/c8en00071a
Autor:
Ananditya Nugraha, Eric R. Gremmer, Sharon Compeer, Maria Zoupa, Leo T.M. van der Ven, Edwin P. Zwart, Wout Slob
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 137
A challenge in cumulative risk assessment is to model hazard of mixtures. EFSA proposed to only combine chemicals linked to a defined endpoint, in so-called cumulative assessment groups, and use the dose-addition model as a default to predict combine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c10b2901bfe742619ec3342d3d36ba
https://pubmed.ncbi.nlm.nih.gov/31927004
https://pubmed.ncbi.nlm.nih.gov/31927004