Výsledky vyhledávání - "Eric R Fearon"

Akademický článek

BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis

Autor: Naoya Sakamoto, Ying Feng, Carmine Stolfi, Yuki Kurosu, Maranne Green, Jeffry Lin, Megan E Green, Kazuhiro Sentani, Wataru Yasui, Martin McMahon, Karin M Hardiman, Jason R Spence, Nobukatsu Horita, Joel K Greenson, Rork Kuick, Kathleen R Cho, Eric R Fearon

Publikováno v: eLife, Vol 6 (2017)

While 20–30% of colorectal cancers (CRCs) may arise from precursors with serrated glands, only 8–10% of CRCs manifest serrated morphology at diagnosis. Markers for distinguishing CRCs arising from ‘serrated’ versus ‘conventional adenoma’

Externí odkaz: https://doaj.org/article/328cc308d95b4fc8886679eb4f62d0da

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Akademický článek

Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.

Autor: Ying Feng, Naoya Sakamoto, Rong Wu, Jie-Yu Liu, Alexandra Wiese, Maranne E Green, Megan Green, Aytekin Akyol, Badal C Roy, Yali Zhai, Kathleen R Cho, Eric R Fearon

Publikováno v: PLoS Genetics, Vol 11, Iss 11, p e1005638 (2015)

Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated trans

Externí odkaz: https://doaj.org/article/c6b949575e3344bcad1c97c6d7da1dc0

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Akademický článek

Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model.

Autor: Karin M Hardiman, Jianhua Liu, Ying Feng, Joel K Greenson, Eric R Fearon

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e96023 (2014)

Familial adenomatous polyposis (FAP) is often due to adenomatous polyposis coli (APC) gene germline mutations. Somatic APC defects are found in about 80% of colorectal cancers (CRCs) and adenomas. Rapamycin inhibits mammalian target of rapamycin (mTO

Externí odkaz: https://doaj.org/article/bc62b423af1d46478dfd2895a237726f

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Akademický článek

Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.

Autor: Wei Dou, Subhajit Mukherjee, Hao Li, Madhukumar Venkatesh, Hongwei Wang, Sandhya Kortagere, Ariel Peleg, Sridhar S Chilimuri, Zheng-Tao Wang, Ying Feng, Eric R Fearon, Sridhar Mani

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e36075 (2012)

Pregnane X Receptor (PXR), a master regulator of drug metabolism and inflammation, is abundantly expressed in the gastrointestinal tract. Baicalein and its O-glucuronide baicalin are potent anti-inflammatory and anti-cancer herbal flavonoids that und

Externí odkaz: https://doaj.org/article/83f4f4c4ac2944e893712e1d39284591

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Akademický článek

In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe.

Autor: Sharon J Miller, Bishnu P Joshi, Ying Feng, Adam Gaustad, Eric R Fearon, Thomas D Wang

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17384 (2011)

Colorectal cancer (CRC) is a major cause of cancer-related deaths in much of the world. Most CRCs arise from pre-malignant (dysplastic) lesions, such as adenomatous polyps, and current endoscopic screening approaches with white light do not detect al

Externí odkaz: https://doaj.org/article/8e0c0adde60a4e1698ab8287ed4a1e14

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Akademický článek

MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells.

Autor: Qing Ji, Xinbao Hao, Min Zhang, Wenhua Tang, Meng Yang, Ling Li, Debing Xiang, Jeffrey T Desano, Guido T Bommer, Daiming Fan, Eric R Fearon, Theodore S Lawrence, Liang Xu

Publikováno v: PLoS ONE, Vol 4, Iss 8, p e6816 (2009)

MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell proliferation and/or cell death. Transcription of the three miRNA miR-34 family members was r

Externí odkaz: https://doaj.org/article/f2afcdcac1f549209a1da11deb17e81e

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