Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eric R, Wengert"'
Autor:
Jeremy A. Thompson, Raquel M. Miralles, Eric R. Wengert, Pravin K. Wagley, Wenxi Yu, Ian C. Wenker, Manoj K. Patel
Publikováno v:
Epilepsia Open, Vol 7, Iss 2, Pp 280-292 (2022)
Abstract Objective SCN8A epileptic encephalopathy is caused predominantly by de novo gain‐of‐function mutations in the voltage‐gated sodium channel Nav1.6. The disorder is characterized by early onset of seizures and developmental delay. Most p
Externí odkaz:
https://doaj.org/article/d2052a1ccd2c4120a7aa09064b084006
Autor:
Eric R. Wengert, Ian C. Wenker, Elizabeth L. Wagner, Pravin K. Wagley, Ronald P. Gaykema, Jung-Bum Shin, Manoj K. Patel
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death amongst patients whose seizures are not adequately controlled by current therapies. Patients with SCN8A encephalopathy have an elevated risk for SUDEP. While transgenic mouse m
Externí odkaz:
https://doaj.org/article/c4a1dcfd7e464abf8d51bcd2c1132236
Autor:
Pravin K. Wagley, Manoj K. Patel, Jeremy A. Thompson, Wenxi Yu, Ian C. Wenker, Raquel M Miralles, Eric R. Wengert
Publikováno v:
Epilepsia Open. 7:280-292
Objective SCN8A epileptic encephalopathy is caused predominantly by de novo gain-of-function mutations in the voltage-gated-sodium channel Nav 1.6. The disorder is characterized by early onset of seizures and developmental delay. Most patients with S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac97a412538a1a2538b0b25c5dc9980
https://doi.org/10.1002/epi4.12564
https://doi.org/10.1002/epi4.12564
Autor:
Eric R. Wengert, Manoj K. Patel, Jeremy A. Thompson, Payal S. Panchal, Pravin K. Wagley, Raquel M. Miralles, Abrar Majidi Idrissi, Ian C. Wenker, Ronald P. Gaykema, Kyle C. A. Wedgwood, Samantha M. Strohm
Publikováno v:
The Journal of Neuroscience. 41:9257-9273
SCN8Aepileptic encephalopathy is a devastating epilepsy syndrome caused by mutantSCN8A, which encodes the voltage-gated sodium channel NaV1.6. To date, it is unclear if and how inhibitory interneurons, which express NaV1.6, influence disease patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ee380df2e06201f55f86827fd518ab2
https://doi.org/10.1523/jneurosci.0718-21.2021
https://doi.org/10.1523/jneurosci.0718-21.2021
Autor:
Matthew R. Kaminski, Guy A. Baldassarre, J. Brian Davis, Eric R. Wengert, Richard M. Kaminski
Publikováno v:
Wildlife Society Bulletin, Vol 37, Iss 4, Pp 778-786 (2013)
ABSTRACT Ecology of mallards (Anas platyrhynchos) breeding in the Lower Great Lakes Region of the United States has not been investigated as comprehensively as mid‐continent populations of this species. We studied mallard breeding ecology in the Co
Externí odkaz:
https://doaj.org/article/be54ff21623d4f35b7aac1c8ded5cc8f
Autor:
Eric R. Wengert, Manoj K. Patel
Publikováno v:
Epilepsy Currents
Voltage-gated sodium channels (VGSCs) are foundational to excitable cell function: Their coordinated passage of sodium ions into the cell is critical for the generation and propagation of action potentials throughout the nervous system. The classical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3508fae321476419eb0d7068ca9efc
http://europepmc.org/articles/PMC7863310
http://europepmc.org/articles/PMC7863310
Autor:
Eric R. Wengert, Manoj K. Patel
Publikováno v:
Brain
Epilepsy Currents
Epilepsy Currents
Variant-Specific Changes in Persistent or Resurgent Sodium Current in SCN8A-Related Epilepsy Patient-Derived Neurons Tidball AM, Lopez-Santiago LF, Yuan Y, et al. Brain. 2020;143(10):3025-3040. doi:10.1093/brain/awaa247Missense variants in the SCN8A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7bdd5fa7e95ec09354715ba3731da7
https://doi.org/10.1177/15357597211002206
https://doi.org/10.1177/15357597211002206
Autor:
Eric R. Wengert, Manoj K. Patel, Anne Christiansen, Ian C. Wenker, Pravin K. Wagley, Nuha Reza, Gene Liau, Samantha M. Strohm, Ronald P. Gaykema
Publikováno v:
Brain research. 1775
Dravet Syndrome (DS) is a severe developmental and epileptic encephalopathy typically caused by loss-of-function de novo mutations in the SCN1A gene which encodes the voltage-gated sodium channel isoform NaV1.1. Decreased NaV1.1 expression results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aca1cba7ecdfbda8882cb59f40f127e
https://pubmed.ncbi.nlm.nih.gov/34843701
https://pubmed.ncbi.nlm.nih.gov/34843701
Autor:
Eric R. Wengert
Publikováno v:
Science (New York, N.Y.). 373(6557)
Nestled in a state park, the wedding was a perfect opportunity to take a break from my Ph.D. and celebrate the union of my close friends. But my mind was somewhere else. Moments earlier, as my wife and I were waiting for the ceremony to begin, I took
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1512620c3426c8062881ae3f284d81cf
https://pubmed.ncbi.nlm.nih.gov/34413239
https://pubmed.ncbi.nlm.nih.gov/34413239
Autor:
Keisuke Kaneko, Christopher B. Currin, Kevin M. Goff, Eric R. Wengert, Ala Somarowthu, Tim P. Vogels, Ethan M. Goldberg
Publikováno v:
Cell reports. 38(13)
Dravet syndrome is a neurodevelopmental disorder characterized by epilepsy, intellectual disability, and sudden death due to pathogenic variants in SCN1A with loss of function of the sodium channel subunit Nav1.1. Nav1.1-expressing parvalbumin GABAer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9960605095e4230eebbf3e9495d54ca9
https://pubmed.ncbi.nlm.nih.gov/35354025
https://pubmed.ncbi.nlm.nih.gov/35354025