Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Eric Q. Wei"'
Autor:
Maiko Matsui, Lauren E. Lynch, Isabella Distefano, Allison Galante, Aravind R. Gade, Hong-Gang Wang, Nicolas Gómez-Banoy, Patrick Towers, Daniel S. Sinden, Eric Q. Wei, Adam S. Barnett, Kenneth Johnson, Renan Lima, Alfonso Rubio-Navarro, Ang K. Li, Steven O. Marx, Timothy E. McGraw, Paul S. Thornton, Katherine W. Timothy, James C. Lo, Geoffrey S. Pitt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The canonical G406R mutation that increases Ca2+ influx through the CACNA1C-encoded CaV1.2 Ca2+ channel underlies the multisystem disorder Timothy syndrome (TS), characterized by life-threatening arrhythmias. Severe episodic hypoglycemia is
Externí odkaz:
https://doaj.org/article/c69ae191aabc414ca794e63e3df33805
Autor:
Maxwell D. Coll, Mounica Yanamandala, Enrico G. Ferro, Mandeep R. Mehra, Eric Q. Wei, Cameron T Nutt, Christine J. Wang
Publikováno v:
JACC Case Reports
A previously healthy 39-year-old man presented in cardiogenic shock with evidence of multisystem inflammatory syndrome of adults 2 months after a mild case of coronavirus disease 2019. He was treated with intravenous immunoglobulin and pulse-dose cor
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(20)
In response to chronic pressure overload, the heart undergoes pathological hypertrophy associated with adverse remodeling, fibrosis, and cardiac dysfunction. Caveolae, membrane invaginations that organize protective signaling pathways and provide a r
Publikováno v:
Proceedings of the National Academy of Sciences. 114
The fibroblast growth factor (FGF) homologous factor FGF13, a noncanonical FGF, has been best characterized as a voltage-gated Na+ channel auxiliary subunit. Other cellular functions have been suggested, but not explored. In inducible, cardiac-specif
Autor:
He Tang, Geoffrey S. Pitt, Hailin Zhang, Chuan Wang, Xiangchong Wang, Yong-Jian Zhang, Jing Yang, Rong Yang, Sheng Wang, Zhihua Wang, Eric Q. Wei
Publikováno v:
Journal of molecular and cellular cardiology. 104
The intracellular fibroblast growth factors (iFGF/FHFs) bind directly to cardiac voltage gated Na+ channels, and modulate their function. Mutations that affect iFGF/FHF-Na+ channel interaction are associated with arrhythmia syndromes. Although suspec
Publikováno v:
Circulation research. 113(4)
Rationale : Fibroblast growth factor (FGF) homologous factors (FHFs; FGF11–14) are intracellular modulators of voltage-gated Na + channels, but their cellular distribution in cardiomyocytes indicated that they performed other functions. Objective :
Autor:
David J. Tester, Jessica A. Hennessey, Eric Q. Wei, Chaojian Wang, Federica Dagradi, Geoffrey S. Pitt, Michael J. Ackerman, Margherita Torchio, Lia Crotti, Chuan Wang, Peter J. Schwartz, Cherisse A. Marcou
Background Less than 30% of the cases of Brugada syndrome (BrS) have an identified genetic cause. Of the known BrS-susceptibility genes, loss-of-function mutations in SCN5A or CACNA1C and their auxiliary subunits are most common. On the basis of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5663d054d80bf232476c4c6f71921880
http://hdl.handle.net/10281/189527
http://hdl.handle.net/10281/189527
The four fibroblast growth factor homologous factors (FHFs, FGF11–FGF14) are intracellular proteins that bind and modulate voltage-gated sodium channels (VGSCs). While FHFs have been well studied in neurons and implicated in neurologic disease, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba99304edc2c0282ff5b7cd7984dba67
https://europepmc.org/articles/PMC3413878/
https://europepmc.org/articles/PMC3413878/
Autor:
Scott Rankin, Matthew Kofron, Hugh R. Woodland, Eric Q. Wei, Janet Heasman, Debora Sinner, Aaron M. Zorn, Pavel Kirilenko, Laura Howard
Publikováno v:
Development (Cambridge, England). 133(10)
A conserved molecular pathway has emerged controlling endoderm formation in Xenopus zebrafish and mice. Key genes in this pathway include Nodal ligands and transcription factors of the Mix-like paired homeodomain class,Gata4-6 zinc-finger factors and