Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Eric Q, Parkhill"'
Autor:
Dmitry O, Koltun, Eric Q, Parkhill, Elfatih, Elzein, Tetsuya, Kobayashi, Gregory T, Notte, Rao, Kalla, Robert H, Jiang, Xiaofen, Li, Thao D, Perry, Belem, Avila, Wei-Qun, Wang, Catherine, Smith-Maxwell, Arvinder K, Dhalla, Sridharan, Rajamani, Brian, Stafford, Jennifer, Tang, Nevena, Mollova, Luiz, Belardinelli, Jeff A, Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3202-3206
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Autor:
Jeff A, Zablocki, Elfatih, Elzein, Xiaofen, Li, Dmitry O, Koltun, Eric Q, Parkhill, Tetsuya, Kobayashi, Ruben, Martinez, Britton, Corkey, Haibo, Jiang, Thao, Perry, Rao, Kalla, Gregory T, Notte, Oliver, Saunders, Michael, Graupe, Yafan, Lu, Chandru, Venkataramani, Juan, Guerrero, Jason, Perry, Mark, Osier, Robert, Strickley, Gongxin, Liu, Wei-Qun, Wang, Lufei, Hu, Xiao-Jun, Li, Nesrine, El-Bizri, Ryoko, Hirakawa, Kris, Kahlig, Cheng, Xie, Cindy Hong, Li, Arvinder K, Dhalla, Sridharan, Rajamani, Nevena, Mollova, Daniel, Soohoo, Eve-Irene, Lepist, Bernard, Murray, Gerry, Rhodes, Luiz, Belardinelli, Manoj C, Desai
Publikováno v:
Journal of medicinal chemistry. 59(19)
Late sodium current (late I
Autor:
Dmitry O. Koltun, Timur M. Zilbershtein, Vasily A. Migulin, Natalya I. Vasilevich, Eric Q. Parkhill, Andrei I. Glushkov, Malcolm J. McGregor, Sandra A. Brunn, Nancy Chu, Jia Hao, Nevena Mollova, Kwan Leung, Jeffrey W. Chisholm, Jeff Zablocki
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
Two structurally distinct series of SCD (Delta9 desaturase) inhibitors (1 and 2) have been previously reported by our group. In the present work, we merged the structural features of the two series. This led to the discovery of compound 5b (CVT-12,01