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of 50
pro vyhledávání: '"Eric Petitclerc"'
Autor:
Jessica S Fortin, Alexandre Patenaude, Rena G Deschesnes, Marie-France Côté, Eric Petitclerc, René C.-Gaudreault
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 13, Iss 2 (2010)
PURPOSE. We investigated the involvement of MAPK signaling in the cell death mechanisms of classical microtubule interfering agents (MIA) and aryl-3-(2-chloroethyl)ureas (CEU) acting as antimitotics, along with CEU that don’t affect directly microt
Externí odkaz:
https://doaj.org/article/53a1881ce0b84ba29a05b27c0efbe9e2
Autor:
François Marceau, Eric Petitclerc
Publikováno v:
International Immunopharmacology. 110:109042
The Food and Drug Administration recently approved the new drug avacopan for a relatively rare disease, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis. Avacopan is an antagonist of receptor-1 for anaphylatoxin C5a (C5aR
Autor:
Jacques Lacroix, Eric Petitclerc, René C.-Gaudreault, Alexandre Patenaude, Réna DeschenesR. Deschenes, Marie-France Côté, Jessica S. Fortin
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 88:1102-1114
Aryl chloroethyl ureas (CEUs) are new protein alkylating agents exhibiting anticancer activity both in vitro and in vivo. We report herein that14C-labeled CEU derivatives, designated CEU-025 and CEU-027, covalently bind to thioredoxin-1 (TRX1). Coval
Autor:
Jean-Philippe Fortin, François Marceau, Ritchie Audet, Thierry Sabourin, Guy Drapeau, Jean-François Larrivée, Luc Levesque, Denis Godin, Johanne Bouthillier, Guillaume Morissette, Marie-Thérèse Bawolak, Denis deBlois, Steeve Houle, Gérémy Abdull Koumbadinga, Lajos Gera, Eric Petitclerc
Publikováno v:
International Immunopharmacology. 10:1344-1353
The blood vessels are one of the important target tissues for the mediators of inflammation and allergy; further cytokines affect them in a number of ways. We review the use of the isolated blood vessel mounted in organ baths as an important source o
Publikováno v:
Vascular Pharmacology. 51:50-56
Restenosis, the re-occlusion of a diseased vessel following a surgical intervention, is a major cause of failure of angioplasty, stenting, and bypass grafting with natural and synthetic vessels. In healthy vessels, the endothelium exerts a control ov
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:7477-7488
Recently, a subset of N-phenyl-N'-(2-chloroethyl)ureas (CEU) was found abrogating the nuclear translocation of thioredoxin-1 and arresting the cell cycle in G(0)/G(1) phase. Several derivatives were prepared to assess their effect on cell cycle progr
Autor:
Eric Petitclerc, Gaétan Laroche, René C.-Gaudreault, Pascale Chevallier, Karine Vallières, Virginie Gauvreau
Publikováno v:
Bioconjugate Chemistry. 15:1146-1156
This study presents two-step and multistep reactions for modifying the surface of plasma-functionalized poly(tetrafluoroethylene) (PTFE) surfaces for subsequent conjugation of biologically relevant molecules. First, PTFE films were treated by a radio
Autor:
Emmanuelle Mounetou, Eric Petitclerc, Jacques Lacroix, Richard Janvier, Claude Marquis, Jean Legault, René C.-Gaudreault, Jean-Claude Madelmont, Elisabeth Miot-Noirault, Marie-France Côté, Réna G. Deschesnes
Publikováno v:
Cancer Research. 64:4654-4663
The development of new anticancer agents with lower toxicity, higher therapeutic index, and weaker tendency to induce resistant phenotypes in tumor cells is a continuous challenge for the scientific community. Toward that end, we showed previously th
Publikováno v:
International Journal of Cancer. 112:830-839
Little is known about the interaction of tumor cells with host vascular smooth muscle cells. In reconstitution experiments, tumorigenic cell lines (including the rat hepatocarcinoma Morris 7777 and human melanoma M-21) were cultured for 17 hr in the
Autor:
François Marceau, Albert Adam, Jean-Philippe Fortin, Giuseppe Molinaro, Thierry Sabourin, Eric Petitclerc, Steeve Houle
Publikováno v:
International Immunopharmacology. 2:1729-1739
Two types of receptors (B1R, B2R) for kinins are defined in mammalian species. Comparative experiments involving recombinant fusion proteins consisting of rabbit B1R or B2R fused to GFP-related proteins are exploited to study the regulation of the re