Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Eric P. Parker"'
Autor:
Josh Kenchel, Alberto Vázquez-Salazar, Reno Wells, Krishna Brunton, Evan Janzen, Kyle M. Schultz, Ziwei Liu, Weiwei Li, Eric T. Parker, Jason P. Dworkin, Irene A. Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Modern life is essentially homochiral, containing D-sugars in nucleic acid backbones and L-amino acids in proteins. Since coded proteins are theorized to have developed from a prebiotic RNA World, the homochirality of L-amino acids observed
Externí odkaz:
https://doaj.org/article/ebe27735b17b455bbcabf82d69dea8ba
Autor:
Yoshinori Takano, Hiroshi Naraoka, Jason P. Dworkin, Toshiki Koga, Kazunori Sasaki, Hajime Sato, Yasuhiro Oba, Nanako O. Ogawa, Toshihiro Yoshimura, Kenji Hamase, Naohiko Ohkouchi, Eric T. Parker, José C. Aponte, Daniel P. Glavin, Yoshihiro Furukawa, Junken Aoki, Kuniyuki Kano, Shin-ichiro M. Nomura, Francois-Regis Orthous-Daunay, Philippe Schmitt-Kopplin, Hayabusa2-initial-analysis SOM team, Hisayoshi Yurimoto, Tomoki Nakamura, Takaaki Noguchi, Ryuji Okazaki, Hikaru Yabuta, Kanako Sakamoto, Toru Yada, Masahiro Nishimura, Aiko Nakato, Akiko Miyazaki, Kasumi Yogata, Masanao Abe, Tatsuaki Okada, Tomohiro Usui, Makoto Yoshikawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Satoru Nakazawa, Sei-ichiro Watanabe, Yuichi Tsuda, Shogo Tachibana
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract We report primordial aqueous alteration signatures in water-soluble organic molecules from the carbonaceous asteroid (162173) Ryugu by the Hayabusa2 spacecraft of JAXA. Newly identified low-molecular-weight hydroxy acids (HO-R-COOH) and dica
Externí odkaz:
https://doaj.org/article/9fc91c5f402d463e92ebe18d8a76ce6c
Autor:
Aogu Furusho, Chiharu Ishii, Takeyuki Akita, Mai Oyaide, Masashi Mita, Hiroshi Naraoka, Yoshinori Takano, Jason P. Dworkin, Yasuhiro Oba, Toshiki Koga, Kazuhiko Fukushima, Dan Aoki, Minako Hashiguchi, Hajime Mita, Yoshito Chikaraishi, Naohiko Ohkouchi, Nanako O. Ogawa, Saburo Sakai, Daniel P. Glavin, Jamie E. Elsila, Eric T. Parker, José C. Aponte, Hannah L. McLain, Francois-Regis Orthous-Daunay, Véronique Vuitton, Roland Thissen, Cédric Wolters, Philippe Schmitt-Kopplin, Alexander Ruf, Junko Isa, Norbert Hertkorn, John M. Eiler, Toshihiro Yoshimura, Haruna Sugahara, Heather V. Graham, Yoshihiro Furukawa, Daisuke Araoka, Satoru Tanaka, Takaaki Yoshikawa, Fumie Kabashima, Kazunori Sasaki, Hajime Sato, Tomoya Yamazaki, Morihiko Onose, Mayu Morita, Yuki Kimura, Kuniyuki Kano, Junken Aoki, Kosuke Fujishima, Shin-ichiro Nomura, Shogo Tachibana, Tomoki Nakamura, Takaaki Noguchi, Ryuji Okazaki, Hikaru Yabuta, Hisayoshi Yurimoto, Kanako Sakamoto, Toru Yada, Masahiro Nishimura, Aiko Nakato, Akiko Miyazaki, Kasumi Yogata, Masanao Abe, Tomohiro Usui, Makoto Yoshikawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Satoru Nakazawa, Tatsuaki Okada, Sei-ichiro Watanabe, Yuichi Tsuda, Kenji Hamase
Publikováno v:
Journal of Chromatography Open, Vol 5, Iss , Pp 100134- (2024)
The chirality of amino acids in extraterrestrial materials may provide an insight into the origin of the essential l-enantiopure amino acids in the terrestrial biosphere. In 2020, the Hayabusa2 mission succeeded in bringing back surface materials fro
Externí odkaz:
https://doaj.org/article/fbb1f42e0fee4af99f3ee9adc718798f
Autor:
Toshihiro Yoshimura, Yoshinori Takano, Hiroshi Naraoka, Toshiki Koga, Daisuke Araoka, Nanako O. Ogawa, Philippe Schmitt-Kopplin, Norbert Hertkorn, Yasuhiro Oba, Jason P. Dworkin, José C. Aponte, Takaaki Yoshikawa, Satoru Tanaka, Naohiko Ohkouchi, Minako Hashiguchi, Hannah McLain, Eric T. Parker, Saburo Sakai, Mihoko Yamaguchi, Takahiro Suzuki, Tetsuya Yokoyama, Hisayoshi Yurimoto, Tomoki Nakamura, Takaaki Noguchi, Ryuji Okazaki, Hikaru Yabuta, Kanako Sakamoto, Toru Yada, Masahiro Nishimura, Aiko Nakato, Akiko Miyazaki, Kasumi Yogata, Masanao Abe, Tatsuaki Okada, Tomohiro Usui, Makoto Yoshikawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Satoru Nakazawa, Sei-ichiro Watanabe, Yuichi Tsuda, Shogo Tachibana, Hayabusa2-initial-analysis SOM team
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Samples from the carbonaceous asteroid (162173) Ryugu provide information on the chemical evolution of organic molecules in the early solar system. Here we show the element partitioning of the major component ions by sequential extractions o
Externí odkaz:
https://doaj.org/article/a8365f2b1660426c828fe3e327fedd7e
Autor:
Minako Hashiguchi, Dan Aoki, Kazuhiko Fukushima, Hiroshi Naraoka, Yoshinori Takano, Jason P. Dworkin, Karin E. Dworkin, José C. Aponte, Jamie E. Elsila, John M. Eiler, Yoshihiro Furukawa, Aogu Furusho, Daniel P. Glavin, Heather V. Graham, Kenji Hamase, Norbert Hertkorn, Junko Isa, Toshiki Koga, Hannah L. McLain, Hajime Mita, Yasuhiro Oba, Nanako O. Ogawa, Naohiko Ohkouchi, Francois-Regis Orthous-Daunay, Eric T. Parker, Alexander Ruf, Saburo Sakai, Philippe Schmitt-Kopplin, Haruna Sugahara, Roland Thissen, Véronique Vuitton, Cédric Wolters, Toshihiro Yoshimura, Hisayoshi Yurimoto, Tomoki Nakamura, Takaaki Noguchi, Ryuji Okazaki, Hikaru Yabuta, Kanako Sakamoto, Shogo Tachibana, Toru Yada, Masahiro Nishimura, Aiko Nakato, Akiko Miyazaki, Kasumi Yogata, Masanao Abe, Tomohiro Usui, Makoto Yoshikawa, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Satoru Nakazawa, Sei-ichiro Watanabe, Yuichi Tsuda
Publikováno v:
Earth, Planets and Space, Vol 75, Iss 1, Pp 1-25 (2023)
Abstract We performed in-situ analysis on a ~ 1 mm-sized grain A0080 returned by the Hayabusa2 spacecraft from near-Earth asteroid (162173) Ryugu to investigate the relationship of soluble organic matter (SOM) to minerals. Desorption electrospray ion
Externí odkaz:
https://doaj.org/article/9c42a14dfb8b4ad99257c12821b27206
Autor:
José C. Aponte, Jason P. Dworkin, Daniel P. Glavin, Jamie E. Elsila, Eric T. Parker, Hannah L. McLain, Hiroshi Naraoka, Ryuji Okazaki, Yoshinori Takano, Shogo Tachibana, Guannan Dong, Sarah S. Zeichner, John M. Eiler, Hisayoshi Yurimoto, Tomoki Nakamura, Hikaru Yabuta, Fuyuto Terui, Takaaki Noguchi, Kanako Sakamoto, Toru Yada, Masahiro Nishimura, Aiko Nakato, Akiko Miyazaki, Kasumi Yogata, Masanao Abe, Tatsuaki Okada, Tomohiro Usui, Makoto Yoshikawa, Takanao Saiki, Satoshi Tanaka, Satoru Nakazawa, Yuichi Tsuda, Sei-ichiro Watanabe, The Hayabusa2-initial-analysis SOM team, The Hayabusa2-initial-analysis core team
Publikováno v:
Earth, Planets and Space, Vol 75, Iss 1, Pp 1-14 (2023)
Abstract Evaluating the molecular distribution of organic compounds in pristine extraterrestrial materials is cornerstone to understanding the abiotic synthesis of organics and allows us to better understand the molecular diversity available during t
Externí odkaz:
https://doaj.org/article/b0a3be3c34224fdc820bb6258c97a711
Autor:
Lauran R. Madden, Theresa V. Nguyen, Salvador Garcia-Mojica, Vishal Shah, Alex V. Le, Andrea Peier, Richard Visconti, Eric M. Parker, Sharon C. Presnell, Deborah G. Nguyen, Kelsey N. Retting
Publikováno v:
iScience, Vol 2, Iss , Pp 156-167 (2018)
Summary: The human intestinal mucosa is a critical site for absorption, distribution, metabolism, and excretion (ADME)/Tox studies in drug development and is difficult to recapitulate in vitro. Using bioprinting, we generated three-dimensional (3D) i
Externí odkaz:
https://doaj.org/article/9ffe43add60e4a288a162976300c9684
Autor:
Nicholas B. Hastings, Xiaohai Wang, Lixin Song, Brent D. Butts, Diane Grotz, Richard Hargreaves, J. Fred Hess, Kwok-Lam Karen Hong, Cathy Ruey-Ruey Huang, Lynn Hyde, Maureen Laverty, Julie Lee, Diane Levitan, Sherry X. Lu, Maureen Maguire, Veeravan Mahadomrongkul, Ernest J. McEachern, Xuesong Ouyang, Thomas W. Rosahl, Harold Selnick, Michaela Stanton, Giuseppe Terracina, David J. Vocadlo, Ganfeng Wang, Joseph L. Duffy, Eric M. Parker, Lili Zhang
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-16 (2017)
Abstract Background Hyperphosphorylation of microtubule-associated protein tau is a distinct feature of neurofibrillary tangles (NFTs) that are the hallmark of neurodegenerative tauopathies. O-GlcNAcylation is a lesser known post-translational modifi
Externí odkaz:
https://doaj.org/article/1ce645702743455b9fc3c2ca7c604062
Autor:
Danielle N. Simkus, José C. Aponte, Jamie E. Elsila, Eric T. Parker, Daniel P. Glavin, Jason P. Dworkin
Publikováno v:
Life, Vol 9, Iss 2, p 47 (2019)
Soluble organic compositions of extraterrestrial samples offer valuable insights into the prebiotic organic chemistry of the solar system. This review provides a summary of the techniques commonly used for analyzing amino acids, amines, monocarboxyli
Externí odkaz:
https://doaj.org/article/fc200b87cecb469fbdf8f9aa8a515e71
Autor:
Lynn A. Hyde, Qi Zhang, Robert A. Del Vecchio, Prescott T. Leach, Mary E. Cohen-Williams, Lei Chen, Gwendolyn T. Wong, Nansie A. McHugh, Joseph Chen, Guy A. Higgins, Theodros Asberom, Wei Li, Dmitri Pissarnitski, Diane Levitan, Amin A. Nomeir, John W. Clader, Lili Zhang, Eric M. Parker
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2013 (2013)
Substantial evidence implicates -amyloid (A) peptides in the etiology of Alzheimer’s disease (AD). A is produced by the proteolytic cleavage of the amyloid precursor protein by - and -secretase suggesting that -secretase inhibition may provide ther
Externí odkaz:
https://doaj.org/article/992cb89d5ff04869837af4acc77fb5af