Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eric P. Kusnadi"'
Autor:
Lorey K. Smith, Tiffany Parmenter, Margarete Kleinschmidt, Eric P. Kusnadi, Jian Kang, Claire A. Martin, Peter Lau, Riyaben Patel, Julie Lorent, David Papadopoli, Anna Trigos, Teresa Ward, Aparna D. Rao, Emily J. Lelliott, Karen E. Sheppard, David Goode, Rodney J. Hicks, Tony Tiganis, Kaylene J. Simpson, Ola Larsson, Benjamin Blythe, Carleen Cullinane, Vihandha O. Wickramasinghe, Richard B. Pearson, Grant A. McArthur
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Different adaptive mechanisms have been reported to reduce the efficacy of mutant BRAF inhibition in melanoma. Here, the authors show BRAF inhibition induces the translational regulation of metabolic genes leading to acquired therapy resistance.
Externí odkaz:
https://doaj.org/article/059612c027f74f17b5f4fdc038786683
Autor:
Michelle J. Henderson, Klaartje Somers, Murray D. Norris, Michelle Haber, Ross D. Hannan, Richard B. Pearson, Eric P. Kusnadi, Andrew J. Gifford, Alvin Kamili, Jamie I. Fletcher, Katherine M. Hannan, Pooja Venkat, Chelsea Mayoh, MoonSun Jung, Jixuan Gao
Supplementary material includes the following: Supplementary Methods: apoptosis assay. Supplementary Table S1: univariate analysis of various risk factors, high ABCE1 or ABCF1 expression on neuroblastoma patient event-free survival. Supplementary Tab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56810665c3d1a3eda6d9789b9213893a
https://doi.org/10.1158/0008-5472.22425135
https://doi.org/10.1158/0008-5472.22425135
Autor:
Michelle J. Henderson, Klaartje Somers, Murray D. Norris, Michelle Haber, Ross D. Hannan, Richard B. Pearson, Eric P. Kusnadi, Andrew J. Gifford, Alvin Kamili, Jamie I. Fletcher, Katherine M. Hannan, Pooja Venkat, Chelsea Mayoh, MoonSun Jung, Jixuan Gao
The ability of the N-MYC transcription factor to drive cancer progression is well demonstrated in neuroblastoma, the most common extracranial pediatric solid tumor, where MYCN amplification heralds a poor prognosis, with only 11% of high-risk patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8a5a2fee436168d4b6ccf6aa1cecb50
https://doi.org/10.1158/0008-5472.c.6511953.v1
https://doi.org/10.1158/0008-5472.c.6511953.v1
Autor:
Sarah T. Diepstraten, Flavia Iannizzotto, Richard B. Pearson, Gemma L. Kelly, Ramon Salazar, Joffrey Pelletier, Carol A. Mercer, Marta Garcia-Cajide, Sara C. Kozma, Suresh Peddigari, George Thomas, Antonio Gentilella, Marta Leonor Rodríguez, Eric P Kusnadi, Jian Kang, Virginia Amador, Ana Domostegui
Publikováno v:
Blood. 137:3351-3364
MYC-driven B-cell lymphomas are addicted to increased levels of ribosome biogenesis (RiBi), offering the potential for therapeutic intervention. However, it is unclear whether inhibition of RiBi suppresses lymphomagenesis by decreasing translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df1ed0d1a81ee1e96b63a9936059996
https://doi.org/10.1182/blood.2020007452
https://doi.org/10.1182/blood.2020007452
Autor:
Viacheslav Kriachkov, Angelique R. Ormsby, Eric P. Kusnadi, Hamish E.G. McWilliam, Justine D. Mintern, Shanika L. Amarasinghe, Matthew E. Ritchie, Luc Furic, Danny M. Hatters
Publikováno v:
Journal of Biological Chemistry. 299:102774
Hexanucleotide expansion mutations in C9ORF72 are a frequent cause of amyotrophic lateral sclerosis. We previously reported that long arginine-rich dipeptide repeats (DPRs), mimicking abnormal proteins expressed from the hexanucleotide expansion, cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc669ee620a0bbcc3e2005f680a20ea7
https://doi.org/10.1016/j.jbc.2022.102774
https://doi.org/10.1016/j.jbc.2022.102774
Publikováno v:
Cancers
Cancers, Vol 13, Iss 3254, p 3254 (2021)
Cancers, Vol 13, Iss 3254, p 3254 (2021)
Simple Summary The estrogen and androgen receptors (ER, AR) are key oncogenic drivers and therapeutic targets in breast and prostate cancer, respectively. These receptors bind to DNA and regulate gene expression but emerging evidence indicates that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a170d9228f21c5f99f94a02d42a4db
http://europepmc.org/articles/PMC8268847
http://europepmc.org/articles/PMC8268847
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1869(1)
Translation of an mRNA represents a critical step during the expression of protein-coding genes. As mechanisms governing post-transcriptional regulation of gene expression are progressively unveiled, it is becoming apparent that transcriptional progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0135dd5c5ffade7a9a3ef50e6d774bff
https://pubmed.ncbi.nlm.nih.gov/34599983
https://pubmed.ncbi.nlm.nih.gov/34599983
Autor:
David P De Souza, Anna S Trigos, Malcolm J. McConville, Keefe T. Chan, Grant A. McArthur, David L Goode, Gretchen Poortinga, Ross D. Hannan, Eric P Kusnadi, Jennifer R. Devlin, George Thomas, Carleen Cullinane, Katherine M. Hannan, Ola Larsson, Richard B. Pearson, Elaine Sanij, Jian Kang
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
The EMBO Journal
Universidad de Barcelona
The EMBO Journal
Elevated ribosome biogenesis in oncogene‐driven cancers is commonly targeted by DNA‐damaging cytotoxic drugs. Our previous first‐in‐human trial of CX‐5461, a novel, less genotoxic agent that specifically inhibits ribosome biogenesis via sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c35944ca8bf201042cb4cbcad74040
http://hdl.handle.net/2445/173389
http://hdl.handle.net/2445/173389
Autor:
Ross D. Hannan, Jamie I. Fletcher, Chelsea Mayoh, Michelle Haber, Richard B. Pearson, MoonSun Jung, Michelle J. Henderson, Katherine M. Hannan, Murray D. Norris, Klaartje Somers, Andrew J. Gifford, Pooja Venkat, Eric P Kusnadi, Alvin Kamili, Jixuan Gao
Publikováno v:
Cancer research. 80(17)
The ability of the N-MYC transcription factor to drive cancer progression is well demonstrated in neuroblastoma, the most common extracranial pediatric solid tumor, where MYCN amplification heralds a poor prognosis, with only 11% of high-risk patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7058defaeb51de63443ace2f88b6d13
https://pubmed.ncbi.nlm.nih.gov/32651259
https://pubmed.ncbi.nlm.nih.gov/32651259
Autor:
Eric P Kusnadi, Katherine M. Hannan, Gretchen Poortinga, Grant A. McArthur, David L Goode, Ross D. Hannan, Jennifer R. Devlin, Ola Larsson, George Thomas, Elaine Sanij, Malcolm J. McConville, Richard B. Pearson, David P De Souza, Anna S Trigos, Jian Kang, Carleen Cullinane, Keefe T. Chan
Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our first-in-human trial of CX-5461, a novel, less genotoxic agent that specifically inhibits ribosome biogenesis via suppression of RNA Pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4627638ea534f337b36f1b9eca00164
https://doi.org/10.1101/847723
https://doi.org/10.1101/847723