Preclinical evaluation of the Hsp90 inhibitor SNX-5422 in ibrutinib resistant CLL

Autor: Alexander Prouty, Jennifer A. Woyach, Amy Lehman, Bonnie K. Harrington, Ronni Wasmuth, Eric Orlemans, Erin Hertlein, Timothy L. Chen, Jean Truxall, Deepa Sampath, Robert A. Baiocchi, Shelby Sloan, Lapo Alinari, John C. Byrd

Publikováno v: Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)

B-cell receptor (BCR) antagonists such as the BTK inhibitor ibrutinib have proven to effectively target chronic lymphocytic leukemia (CLL) tumor cells, leading to impressive response rates in these patients. However patients do still relapse on ibrut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d64b75dc256dd69a11ff76d3c4428b
https://pubmed.ncbi.nlm.nih.gov/33627156

Incidence of Gastroduodenal Ulcers is Significantly Reduced When Analgesic Doses of Aspirin are Administered as PA65020, A Novel Combination of Enteric-Coated Aspirin (EC-ASA) and Immediate-Release (IR) Omeprazole

Autor: Eric Orlemans, John R. Plachetka, John G. Fort, Cemal Unal

Publikováno v: American Journal of Gastroenterology. 104:S514-S515

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb2c40dcdfb0a1f5b3925c8f5b8242c8
https://doi.org/10.14309/00000434-200910003-01376

T1969 Gastric Acid Suppression with PN400, a Single-Tablet, Multilayer, Fixed-Dose Formulation Combining An Immediate-Release Esomeprazole Layer and An Enteric-Coated (EC) Naproxen Core

Autor: John R. Plachetka, John G. Fort, Mark Sostek, Philip B. Miner, Eric Orlemans

Publikováno v: Gastroenterology. 136:A-611

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe3ffeebcc76eed113851046feb94632
https://doi.org/10.1016/s0016-5085(09)62816-x

Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma.

Autor: Pahwa, Roma¹ (AUTHOR), Dubhashi, Janhavi^1,2 (AUTHOR), Singh, Anand³ (AUTHOR), Jailwala, Parthav⁴ (AUTHOR), Lobanov, Alexei⁴ (AUTHOR), Thomas, Craig J.⁵ (AUTHOR), Ceribelli, Michele⁵ (AUTHOR), Wilson, Kelli⁵ (AUTHOR), Ricketts, Christopher J.¹ (AUTHOR), Vocke, Cathy D.¹ (AUTHOR), Wells, Catherine¹ (AUTHOR), Bottaro, Donald P.¹ (AUTHOR), Linehan, W. Marston¹ (AUTHOR), Neckers, Len¹ (AUTHOR), Srinivasan, Ramaprasad¹ (AUTHOR) ramasrin@mail.nih.gov

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 6/27/2022, Vol. 41 Issue 1, p1-17. 17p.

Clinical trial: evaluation of gastric acid suppression with three doses of immediate-release esomeprazole in the fixed-dose combination of PN 400 (naproxen/esomeprazole magnesium) compared with naproxen 500 mg and enteric-coated esomeprazole 20 mg: a randomized, open-label, Phase I study in healthy volunteers

Autor: Miner, P.¹ (AUTHOR), Plachetka, J.² (AUTHOR), Orlemans, E.² (AUTHOR), Fort, J. G.² (AUTHOR), Sostek, M.³ (AUTHOR)

Publikováno v: Alimentary Pharmacology & Therapeutics. Aug2010, Vol. 32 Issue 3, p414-424. 11p. 1 Diagram, 5 Charts, 2 Graphs.