Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Eric O. Williams"'
Autor:
Kana Tominaga, Naoomi Tominaga, Eric O. Williams, Laura Rufibach, Verena Schöwel, Simone Spuler, Mohan Viswanathan, Leonard P. Guarente
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103667- (2022)
Summary: Dysferlinopathies are muscular dystrophies caused by recessive loss-of-function mutations in dysferlin (DYSF), a membrane protein involved in skeletal muscle membrane repair. We describe a cell-based assay in which human DYSF proteins bearin
Externí odkaz:
https://doaj.org/article/73164fe44e8b4b86ae29ce9235c5dd34
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 809-820 (2016)
The enhancer landscape is dramatically restructured as naive preimplantation epiblasts transition to the post-implantation state of primed pluripotency. A key factor in this process is Otx2, which is upregulated during the early stages of this transi
Externí odkaz:
https://doaj.org/article/41073b814cba4fd8995271518bee3ab1
Autor:
Petra Simic, Eric O. Williams, Eric L. Bell, Jing Jing Gong, Michael Bonkowski, Leonard Guarente
Publikováno v:
Cell Reports, Vol 3, Iss 4, Pp 1175-1186 (2013)
The epithelial-to-mesenchymal transition (EMT) is important for the development of cancer metastases and organ fibrosis, conditions prevalent in aging. Because sirtuins affect the pathology of aging, we tested the effect of SirT1 on EMT. Reduced SIRT
Externí odkaz:
https://doaj.org/article/73d53392cf324778b58da00d7df77e7c
Autor:
Naoomi Tominaga, Kana Tominaga, Simone Spuler, Leonard Guarente, Eric O. Williams, Verena Schöwel, Mohan Viswanathan, Laura E. Rufibach
Publikováno v:
SSRN Electronic Journal.
Dysferlinopathies are muscular dystrophies caused by recessive loss-of-function mutations in dysferlin ( DYSF), a membrane protein involved in skeletal muscle membrane repair. We describe a cell-based assay in which human DYSF proteins bearing missen
Autor:
Adam J. Bisogni, Jean Yee Hwa Yang, Eric O. Williams, Heather M. Marsh, David M. Lin, Shila Ghazanfar
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
The delta-protocadherins (δ-Pcdhs) play key roles in neural development, and expression studies suggest they are expressed in combination within neurons. The extent of this combinatorial diversity, and how these combinations influence cell adhesion,
Autor:
Takashi Kadowaki, Eric O. Williams, Toshimasa Yamauchi, Frank Jaksch, Masaomi Miura, Masaki Igarashi, Leonard Guarente
Publikováno v:
Aging Cell. 18:e12935
The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but not Paneth cells decline during aging, as does ISC function asses
Autor:
Myung-Jin Kang, Lynn-Jee Kim, Brendan Lee, Brenna Osborne, George X. Huang, James R. Mitchell, Alban Longchamp, Michael B. Schultz, Jose Humberto Treviño-Villarreal, Lindsay E. Wu, Yuancheng Lu, Nigel Turner, David A. Sinclair, Catherine Li, Abhirup Das, Zolt Arany, Tzong-Tyng Hung, Masaki Igarashi, Eric O. Williams, Sanket Joshi, Leonard Guarente, Michael Bonkowski
Publikováno v:
PMC
A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health. NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylas
Autor:
Eric O. Williams, Peter M. Vassilev, Ying Luo, Edward M. Brown, Surya M. Nauli, Andrew E. H. Elia, Francis J. Alenghat, Stephen J. Quinn, Donald E. Ingber, Jing Zhou, Weining Lu, Xiaogang Li
Publikováno v:
Nature Genetics. 33:129-137
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw (encoding polaris). It is not known, however, whether ciliary dysfunct
Autor:
Amanda M. Del Rosario, Eric O. Williams, Ippei Nagamori, Nicki Watson, Leonard Guarente, Forest M. White, Eric L. Bell, Paolo Sassone-Corsi, Bryan D. Bryson
Sirtuins are NAD+-dependent deacylases that regulate numerous biological processes in response to the environment. SirT1 is the mammalian ortholog of yeast Sir2, and is involved in many metabolic pathways in somatic tissues. Whole body deletion of Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f69eb2784972845404ab57143900ae
https://europepmc.org/articles/PMC4197722/
https://europepmc.org/articles/PMC4197722/