Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Eric O. Freed"'
Autor:
Alex Kleinpeter, Donna L. Mallery, Nadine Renner, Anna Albecka, J. Ole Klarhof, Eric O. Freed, Leo C. James
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions ar
Externí odkaz:
https://doaj.org/article/146fe9a36e924c2a89d4ea1eeb9173fc
Autor:
Aidan McGraw, Grace Hillmer, Stefania M. Medehincu, Yuta Hikichi, Sophia Gagliardi, Kedhar Narayan, Hasset Tibebe, Dacia Marquez, Lilia Mei Bose, Adleigh Keating, Coco Izumi, Kevin Peese, Samit Joshi, Mark Krystal, Kathleen L. DeCicco-Skinner, Eric O. Freed, Luca Sardo, Taisuke Izumi
Publikováno v:
Viruses, Vol 16, Iss 9, p 1423 (2024)
HIV-1 virion maturation is an essential step in the viral replication cycle to produce infectious virus particles. Gag and Gag-Pol polyproteins are assembled at the plasma membrane of the virus-producer cells and bud from it to the extracellular comp
Externí odkaz:
https://doaj.org/article/80d24a174b6e4afea42006719a85adfb
Autor:
Sucharita Sarkar, Kaneil K. Zadrozny, Roman Zadorozhnyi, Ryan W. Russell, Caitlin M. Quinn, Alex Kleinpeter, Sherimay Ablan, Hamed Meshkin, Juan R. Perilla, Eric O. Freed, Barbie K. Ganser-Pornillos, Owen Pornillos, Angela M. Gronenborn, Tatyana Polenova
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
HIV maturation inhibitors such as bevirimat (BVM) interfering with Gag processing are emerging as alternative anti-retroviral drug candidates. Here, the authors report structures of assemblies of HIV-1 Gag fragments spanning the CA C-terminal domain
Externí odkaz:
https://doaj.org/article/cbb35289f9cb46858a493c1534ae911c
Autor:
Eric O. Freed
Publikováno v:
Viruses, Vol 16, Iss 4, p 486 (2024)
It is often said that two things in life are certain: death and taxes [...]
Externí odkaz:
https://doaj.org/article/c682bb561d97410f9cee7bacaf77a071
Publikováno v:
Viruses, Vol 16, Iss 2, p 178 (2024)
Dr. Judith G. Levin passed away in Teaneck, NJ, USA, on 8 December 2023 [...]
Externí odkaz:
https://doaj.org/article/9fd36fcd67bf4399b60574d31b678c8c
Autor:
Luiza Mendonça, Dapeng Sun, Jiying Ning, Jiwei Liu, Abhay Kotecha, Mateusz Olek, Thomas Frosio, Xiaofeng Fu, Benjamin A. Himes, Alex B. Kleinpeter, Eric O. Freed, Jing Zhou, Christopher Aiken, Peijun Zhang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Mendonça et al. determine the structures of both in vitro assemblies of the HIV structural precursor protein Gag and Gag viral-like particles (VLPs) to 4.2 Å and 4.5 Å resolutions, using cryo-electron tomography and subtomogram averaging. This stu
Externí odkaz:
https://doaj.org/article/9ab2d7c26554447ba2a91fac3949925b
Autor:
James Kirui, Eric O. Freed
Publikováno v:
Retrovirology, Vol 17, Iss 1, Pp 1-11 (2020)
Abstract Background The continued persistence of HIV-1 as a public health concern due to the lack of a cure calls for the development of new tools for studying replication of the virus. Here, we used NanoLuc, a small and extremely bright luciferase p
Externí odkaz:
https://doaj.org/article/57d968b8f48e4e47a37ccd73b192f262
Autor:
Alice Duchon, Steven Santos, Jianbo Chen, Matthew Brown, Olga A. Nikolaitchik, Sheldon Tai, Jeffrey A. Chao, Eric O. Freed, Vinay K. Pathak, Wei-Shau Hu
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) Gag selects and packages the HIV RNA genome during virus assembly. However, HIV-1 RNA constitutes only a small fraction of the cellular RNA. Although Gag exhibits a slight preference to viral RNA,
Externí odkaz:
https://doaj.org/article/4c52ccae73714e31b32860396048eceb
Autor:
Elodie Mailler, Abdul A. Waheed, Sang-Yoon Park, David C. Gershlick, Eric O. Freed, Juan S. Bonifacino
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-20 (2019)
Abstract Background Nef is a multifunctional accessory protein encoded by HIV-1, HIV-2 and SIV that plays critical roles in viral pathogenesis, contributing to viral replication, assembly, budding, infectivity and immune evasion, through engagement o
Externí odkaz:
https://doaj.org/article/15f486e3b7c54ad2811b555746324431
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Viral envelope glycoproteins are an important structural component on the surfaces of enveloped viruses that direct virus binding and entry and also serve as targets for the host adaptive immune response. In this study, we investigate the mechanism o
Externí odkaz:
https://doaj.org/article/3c7a61ed474c4f8eb8ac2adcfc05c411