Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Eric O Williams"'
Publikováno v:
eLife, Vol 7 (2018)
The delta-protocadherins (δ-Pcdhs) play key roles in neural development, and expression studies suggest they are expressed in combination within neurons. The extent of this combinatorial diversity, and how these combinations influence cell adhesion,
Externí odkaz:
https://doaj.org/article/cb0de718a019401f82d1850f77239a78
Autor:
Eric O Williams, Heather M Sickles, Alison L Dooley, Sierra ePalumbos, Adam J Bisogni, David M Lin
Publikováno v:
Frontiers in Neural Circuits, Vol 5 (2011)
Olfactory sensory neurons (OSNs) are thought to use activity-dependent and independent mechanisms to regulate the expression of axon guidance genes. However, defining the molecular mechanisms that underlie activity-dependent OSN guidance has remained
Externí odkaz:
https://doaj.org/article/f9a7e41ec6a84bbaa6345d038ccc1173
Autor:
Kana Tominaga, Naoomi Tominaga, Eric O. Williams, Laura Rufibach, Verena Schöwel, Simone Spuler, Mohan Viswanathan, Leonard P. Guarente
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103667- (2022)
Summary: Dysferlinopathies are muscular dystrophies caused by recessive loss-of-function mutations in dysferlin (DYSF), a membrane protein involved in skeletal muscle membrane repair. We describe a cell-based assay in which human DYSF proteins bearin
Externí odkaz:
https://doaj.org/article/73164fe44e8b4b86ae29ce9235c5dd34
Autor:
Naoomi Tominaga, Kana Tominaga, Simone Spuler, Leonard Guarente, Eric O. Williams, Verena Schöwel, Mohan Viswanathan, Laura E. Rufibach
Publikováno v:
SSRN Electronic Journal.
Dysferlinopathies are muscular dystrophies caused by recessive loss-of-function mutations in dysferlin ( DYSF), a membrane protein involved in skeletal muscle membrane repair. We describe a cell-based assay in which human DYSF proteins bearing missen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78726ab31f0aa78e0299158431f4aa0f
https://doi.org/10.2139/ssrn.3889708
https://doi.org/10.2139/ssrn.3889708
Autor:
Takashi Kadowaki, Eric O. Williams, Toshimasa Yamauchi, Frank Jaksch, Masaomi Miura, Masaki Igarashi, Leonard Guarente
Publikováno v:
Aging Cell. 18:e12935
The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but not Paneth cells decline during aging, as does ISC function asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee8a5e3b8c8fc566804d0e69a0b84bd6
https://doi.org/10.1111/acel.12935
https://doi.org/10.1111/acel.12935
Autor:
Myung-Jin Kang, Lynn-Jee Kim, Brendan Lee, Brenna Osborne, George X. Huang, James R. Mitchell, Alban Longchamp, Michael B. Schultz, Jose Humberto Treviño-Villarreal, Lindsay E. Wu, Yuancheng Lu, Nigel Turner, David A. Sinclair, Catherine Li, Abhirup Das, Zolt Arany, Tzong-Tyng Hung, Masaki Igarashi, Eric O. Williams, Sanket Joshi, Leonard Guarente, Michael Bonkowski
Publikováno v:
PMC
A decline in capillary density and blood flow with age is a major cause of mortality and morbidity. Understanding why this occurs is key to future gains in human health. NAD precursors reverse aspects of aging, in part, by activating sirtuin deacylas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a496804806a967700e1270795311f64c
https://doi.org/10.1016/j.cell.2018.02.008
https://doi.org/10.1016/j.cell.2018.02.008
Autor:
Eric O. Williams, Peter M. Vassilev, Ying Luo, Edward M. Brown, Surya M. Nauli, Andrew E. H. Elia, Francis J. Alenghat, Stephen J. Quinn, Donald E. Ingber, Jing Zhou, Weining Lu, Xiaogang Li
Publikováno v:
Nature Genetics. 33:129-137
Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw (encoding polaris). It is not known, however, whether ciliary dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13fa978440821e7de71e305681c9dfd
https://doi.org/10.1038/ng1076
https://doi.org/10.1038/ng1076
Autor:
Amanda M. Del Rosario, Eric O. Williams, Ippei Nagamori, Nicki Watson, Leonard Guarente, Forest M. White, Eric L. Bell, Paolo Sassone-Corsi, Bryan D. Bryson
Sirtuins are NAD+-dependent deacylases that regulate numerous biological processes in response to the environment. SirT1 is the mammalian ortholog of yeast Sir2, and is involved in many metabolic pathways in somatic tissues. Whole body deletion of Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f69eb2784972845404ab57143900ae
https://europepmc.org/articles/PMC4197722/
https://europepmc.org/articles/PMC4197722/
Autor:
Roger J. Hajjar, Eric O. Williams, Anthony Rosenzweig, Judith K. Gwathmey, Ulrich Schmidt, Djemal Lebeche, E. Douglas Lewandowski, Federica del Monte
Publikováno v:
Circulation. 104:1424-1429
Background — In heart failure, sarcoplasmic reticulum (SR) Ca 2+ -ATPase (SERCA2a) activity is decreased, resulting in abnormal calcium handling and contractile dysfunction. We have previously shown that increasing SERCA2a expression by gene transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ed2c71c6dc93725b92bde3ae9bfed1
https://doi.org/10.1161/hc3601.095574
https://doi.org/10.1161/hc3601.095574