Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Eric Nybo"'
Autor:
Rongbin, Wang, Jennifer, Nguyen, Jacob, Hecht, Nora, Schwartz, Katelyn V, Brown, Larissa V, Ponomareva, Magdalena, Niemczura, Dino, van Dissel, Gilles P, van Wezel, Jon S, Thorson, Mikko, Metsä-Ketelä, Khaled A, Shaaban, S Eric, Nybo
Publikováno v:
ACS synthetic biology. 11(12)
Actinomycetes produce a variety of clinically indispensable molecules, such as antineoplastic anthracyclines. However, the actinomycetes are hindered in their further development as genetically engineered hosts for the synthesis of new anthracycline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80cdc2ee881fde7607eda741410fee18
https://pubmed.ncbi.nlm.nih.gov/36378506
https://pubmed.ncbi.nlm.nih.gov/36378506
Publikováno v:
J Appl Microbiol
Actinomycetes are prolific sources of bioactive molecules. Traditional workflows including bacterial isolation, fermentation, metabolite identification, and structure elucidation have resulted in high rates of natural product rediscovery in recent ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445e822cbed229c4372f5d0c456fbe6a
https://doi.org/10.1111/jam.15225
https://doi.org/10.1111/jam.15225
Autor:
Claudine E. Bayles, Danielle E. Hale, Ali Konieczny, Veronica D. Anderson, Claire R. Richardson, Katelyn V. Brown, Jennifer T. Nguyen, Jacob Hecht, Nora Schwartz, Madan K. Kharel, Felix Amissah, Thomas C. Dowling, S. Eric Nybo
Publikováno v:
Toxicology and applied pharmacology.
The anthracyclines are a family of natural products isolated from soil bacteria with over 2000 chemical representatives. Since their discovery seventy years ago by Waksman and co-workers, anthracyclines have become one of the best-characterized antic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc8b5e1fc67ad8673ee8d2d5c55f51b
https://pubmed.ncbi.nlm.nih.gov/36592899
https://pubmed.ncbi.nlm.nih.gov/36592899
Publikováno v:
Currents in Pharmacy Teaching and Learning. 12:716-723
Background and purpose Educational escape rooms assist students with the development of teamwork, augmentation of problem-solving skills, and reinforcement of key course concepts. In this report, we examined the feasibility of creating a bioterror pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdc5da5bca0b43b778e64a1204e7960
https://doi.org/10.1016/j.cptl.2020.01.037
https://doi.org/10.1016/j.cptl.2020.01.037
Autor:
Rongbin Wang, Jennifer Nguyen, Jacob Hecht, Nora Schwartz, Katelyn V. Brown, Larissa V. Ponomareva, Magdalena Niemczura, Dino van Dissel, Gilles P. van Wezel, Jon S. Thorson, Mikko Metsä-Ketelä, Khaled A. Shaaban, S. Eric Nybo
Publikováno v:
ACS Synthetic Biology
Actinomycetes produce a variety of clinically indispensable molecules, such as antineoplastic anthracyclines. However, the actinomycetes are hindered in their further development as genetically engineered hosts for the synthesis of new anthracycline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4608614fdcd9ebe8679034ca0a773c6
https://hdl.handle.net/11250/3047960
https://hdl.handle.net/11250/3047960
Autor:
Kennedy K. Riebschleger, S. Eric Nybo, Jennifer T. Nguyen, Katelyn V. Brown, Nina M. Gorgijevska
Publikováno v:
Biotechnol J
BACKGROUND/GOAL/AIM: The tetracenomycins are aromatic anticancer polyketides that inhibit peptide translation via binding to the large ribosomal subunit. Here, we expressed the elloramycin biosynthetic gene cluster in the heterologous host Streptomyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da243de85d47569992ffad4e64b737b
https://pubmed.ncbi.nlm.nih.gov/34719127
https://pubmed.ncbi.nlm.nih.gov/34719127
Autor:
Katelyn V. Brown, Nina M. Gorgijevska, Kennedy K. Riebschleger, S. Eric Nybo, Jennifer T. Nguyen
The tetracenomycins are aromatic anticancer polyketides that inhibit peptide translation via binding to the large ribosomal subunit. Here, we expressed the elloramycin biosynthetic gene cluster in the heterologous host Streptomyces coelicolor M1146 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab983b299b314bfde403b2b07f8bf73
https://doi.org/10.1101/2021.07.23.453519
https://doi.org/10.1101/2021.07.23.453519
Autor:
Eric Nybo, S., Sahr, Michelle, Young, Mark, Axford, Katie, Sohn, Minji, Lyons, Margaret, Klepser, Michael
Publikováno v:
In Currents in Pharmacy Teaching and Learning November 2020 12(11):1340-1347
Publikováno v:
J Org Chem
The anthracyclines are structurally diverse anticancer natural products that bind to DNA and poison the topoisomerase II – DNA complex in cancer cells. Rational modifications in the deoxysugar functionality are especially advantageous for synthesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1edb17033494c3788c730ac275bb84
https://pubmed.ncbi.nlm.nih.gov/32938175
https://pubmed.ncbi.nlm.nih.gov/32938175
Autor:
S. Eric Nybo, Katelyn V. Brown
The sequences of two commonly used pIJ101-based Streptomyces-E. coli shuttle vectors, pEM4 and pUWL201, were determined using next-generation sequencing and mapped. pEM4 was found to be 8.3 kbp long, containing genes encoding β-lactamase, thiostrept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08e07608e0db351b2c9fd944df8a676
https://doi.org/10.1101/2020.02.26.966358
https://doi.org/10.1101/2020.02.26.966358