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of 6
pro vyhledávání: '"Eric Nawrotzky"'
Autor:
Ee Lin Wong, Eric Nawrotzky, Christoph Arkona, Boo Geun Kim, Samuel Beligny, Xinning Wang, Stefan Wagner, Michael Lisurek, Dirk Carstanjen, Jörg Rademann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The oncogene STAT5 is involved in cancer cell proliferation. Here, the authors use STAT5 protein to assemble its own small molecule inhibitors via Mannich ligation (three-component-reactions) and show that the resultant ligands can inhibit the prolif
Externí odkaz:
https://doaj.org/article/2011251d4c4d4f39bd08fae3a0b285a3
Autor:
Markus Tiemann, Eric Nawrotzky, Peter Schmieder, Leon Wehrhan, Silke Bergemann, Vera Martos, Wei Song, Christoph Arkona, Bettina G. Keller, Jörg Rademann
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 28(57)
Discovery of protein-binding fragments for precisely defined binding sites is an unmet challenge to date. Herein, formylglycine is investigated as a molecular probe for the sensitive detection of fragments binding to a spatially defined protein site
Publikováno v:
Angewandte Chemie (Weinheim an Der Bergstrasse, Germany)
Proteintemplat‐gesteuerte Fragmentligationen sind ein neuartiges Konzept zur Unterstützung der Wirkstofffindung und können dazu beitragen, die Wirksamkeit von Proteinliganden zu verbessern. Es handelt sich dabei um chemische Reaktionen zwischen n
Publikováno v:
Angewandte Chemie (International Ed. in English)
Protein‐templated fragment ligation is a novel concept to support drug discovery and can help to improve the efficacy of protein ligands. Protein‐templated fragment ligations are chemical reactions between small molecules (“fragments”) utiliz
Autor:
Xinning Wang, Stefan Wagner, Jörg Rademann, Ee Lin Wong, Eric Nawrotzky, Michael Lisurek, Dirk Carstanjen, Christoph Arkona, Boo Geun Kim, Samuel Beligny
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Protein-templated fragment ligations have been established as a powerful method for the assembly and detection of optimized protein ligands. Initially developed for reversible ligations, the method has been expanded to irreversible reactions enabling
Publikováno v:
Fragment-based Drug Discovery Lessons and Outlook
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2619cfba509efbea065d58a3b5dbb1fb
https://doi.org/10.1002/9783527683604.ch13
https://doi.org/10.1002/9783527683604.ch13