Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Eric N. Burright"'
Autor:
Michael D. Kaytor, Zhiming Zhang, Yi Ai, Peter T. Nelson, Richard Grondin, Deepak R. Thakker, William F. Kaemmerer, Marcy R. Weatherspoon, Jennifer M. Heisel, Eric N. Burright, Janelle L. Blum
Publikováno v:
Brain
Huntington's disease is caused by expression of a mutant form of Huntingtin protein containing an expanded polyglutamine repeat. One possible treatment for Huntington's disease may be to reduce expression of mutant Huntingtin in the brain via RNA int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b204c23054f002e86e2c87b2169fb3
https://doi.org/10.1093/brain/awr333
https://doi.org/10.1093/brain/awr333
Autor:
Chris Hobot, Keith R. Hildebrand, William F. Mckay, John Myers Zanella, Mark Cox, Eric N. Burright, Laura Christoferson
Publikováno v:
Spine. 33:227-234
STUDY DESIGN The effects of a low, local dose of a tumor necrosis factor-alpha (TNF-alpha) inhibitor on neuropathic pain behaviors in a rat chronic constriction injury model were evaluated. OBJECTIVE To investigate whether a peripherally implanted po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccb242f256c546db1e34fecface8e11
https://doi.org/10.1097/brs.0b013e318162340a
https://doi.org/10.1097/brs.0b013e318162340a
Autor:
Eric N. Burright, H. Brent Clark, Nathan D. Jorgensen, A. S. Lysholm, Heliane G. Serra, Tao Zu, Lisa A. Duvick, Kerri M. Carlson, J. Michael Andresen, Sam Stevens, Huda Y. Zoghbi, Harry T. Orr
Publikováno v:
Cell. 127(4):697-708
Spinocerebellar ataxia type 1 (SCA1) is one of nine inherited, typically adult onset, polyglutamine neurodegenerative diseases. To examine whether development impacts SCA1, we used a conditional transgenic mouse model of SCA1 to delay the postnatal e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d656297f8b9d13aaafc2f8a1648ec541
Autor:
Jennifer D. Davidson, Huda Y. Zoghbi, Lisa A. Duvick, Eric N. Burright, Brigit E. Riley, Harry T. Orr
Publikováno v:
Human Molecular Genetics. 9:2305-2312
Expansion of a polyglutamine tract within ataxin-1 causes spinocerebellar ataxia type 1 (SCA1). In this study, we used the yeast two-hybrid system to identify an ataxin-1-interacting protein, A1Up. A1Up localized to the nucleus and cytoplasm of trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7539e8e968cdde8ec6c415881ebc4e
https://doi.org/10.1093/oxfordjournals.hmg.a018922
https://doi.org/10.1093/oxfordjournals.hmg.a018922
Publikováno v:
Human Molecular Genetics. 6:2135-2139
Nucleotide repeat instability is associated with an increasing number of cancers and neurological disorders. The mechanisms that govern repeat instability in these biological disorders are not well understood. To examine genetic aspects of repeat ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66ab95301fa2b20b9588fb1e0e85432
https://doi.org/10.1093/hmg/6.12.2135
https://doi.org/10.1093/hmg/6.12.2135
Publikováno v:
Brain Pathol
Expansions of CAG trinucleotide repeats encoding glutamine have been found to be the causative mutations of seven human neurodegenerative diseases. Similarities in the clinical, genetic, and molecular features of these disorders suggest they share a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d504da07b11ab5a01f3c0f31bd9ced0
https://doi.org/10.1111/j.1750-3639.1997.tb00896.x
https://doi.org/10.1111/j.1750-3639.1997.tb00896.x
Autor:
Jennifer D. Davidson, Huda Y. Zoghbi, Beena T. Koshy, Eric N. Burright, Lisa A. Duvick, Harry T. Orr
Publikováno v:
Human Molecular Genetics. 6:513-518
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by the expansion of a polyglutamine tract within the SCA1 gene product, ataxin-1. Expansion of this tract is believed to result in a gain of function by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aa94092060b084b5ac3afa4f3ba8a9
https://doi.org/10.1093/hmg/6.4.513
https://doi.org/10.1093/hmg/6.4.513
Autor:
Beena T. Koshy, Eric N. Burright, Harry T. Orr, Kenneth H. Fischbeck, Huda Y. Zoghbi, Toni Matilla, Diane E. Merry
Publikováno v:
Human Molecular Genetics. 5:1311-1318
Spinocerebellar ataxia type1 (SCA1) is one of several neurodegenerative disorders caused by expansions of translated CAG trinucleotide repeats which code for polyglutamine in the respective proteins. Most hypotheses about the molecular defect in thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52bf08d06e3d9c353df0319dd129a136
https://doi.org/10.1093/hmg/5.9.1311
https://doi.org/10.1093/hmg/5.9.1311
Autor:
Toni Matilla, Wael S. Yunis, Huda Y. Zoghbi, Harry T. Orr, Antonio Servadio, Rodney M. Feddersen, Lisa A. Duvick, Eric N. Burright, H. Brent Clark
Publikováno v:
Cell. 82:937-948
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant inherited disorder characterized by degeneration of cerebellar Purkinje cells, spinocerebellar tracts, and selective brainstem neurons owing to the expansion of an unstable CAG trinucleoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600673ceb15bfbf725965f5516853f18
https://doi.org/10.1016/0092-8674(95)90273-2
https://doi.org/10.1016/0092-8674(95)90273-2
Publikováno v:
Genomics. 14:649-656
A strategy based on the use of human-specific interspersed repetitive sequence (IRS)-PCR amplification was used to isolate regional DNA markers in the vicinity of the incontinentia pigmenti 1 (IP1) locus. A radiation hybrid (RH) resulting from a fusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05876aebe1be70e63da32bfbc871448
https://doi.org/10.1016/s0888-7543(05)80164-8
https://doi.org/10.1016/s0888-7543(05)80164-8