Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eric Muise"'
Autor:
Dwight Macdonald, Anthony Mastracchio, Hélène Perrier, Daniel Dubé, Michel Gallant, Patrick Lacombe, Denis Deschênes, Bruno Roy, John Scheigetz, Kevin Bateman, Chun Li, Laird A. Trimble, Stephen Day, Nathalie Chauret, Deborah A. Nicoll-Griffith, Jose M. Silva, Zheng Huang, France Laliberté, Susana Liu, Diane Ethier, Doug Pon, Eric Muise, Louise Boulet, Chi Chung Chan, Angela Styhler, Stella Charleson, Joseph Mancini, Paul Masson, David Claveau, Donald Nicholson, Mervyn Turner, Robert N. Young, Yves Girard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5241-5246
The discovery and SAR of a new series of substituted 8-arylquinoline PDE4 inhibitors are herein described. This work has led to the identification of several compounds with excellent in vitro and in vivo profiles, including a good therapeutic window
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff58af67854878403c87410ee5934af1
https://doi.org/10.1016/j.bmcl.2005.08.036
https://doi.org/10.1016/j.bmcl.2005.08.036
Autor:
Richard W. Friesen, Yves Ducharme, Richard G. Ball, Marc Blouin, Louise Boulet, Bernard Côté, Richard Frenette, Mario Girard, Daniel Guay, Zheng Huang, Thomas R. Jones, France Laliberté, Joseph J. Lynch, Joseph Mancini, Evelyn Martins, Paul Masson, Eric Muise, Douglas J. Pon, Peter K. S. Siegl, Angela Styhler, Nancy N. Tsou, Mervyn J. Turner, Robert N. Young, Yves Girard
Publikováno v:
Journal of Medicinal Chemistry. 46:2413-2426
A SAR study on the tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors related to 1 is described. In addition to inhibitory potency against PDE4 and the lipopolysaccharide-induced production of TNFalpha in human whole blood, the binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18495e1aec7ef1822aab54c123463878
https://doi.org/10.1021/jm0204542
https://doi.org/10.1021/jm0204542
Autor:
Daniel Guay, Louise Boulet, Richard W. Friesen, Mario Girard, Pierre Hamel, Zheng Huang, France Laliberté, Sébastien Laliberté, Joseph A. Mancini, Eric Muise, Doug Pon, Angela Styhler
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(20)
A SAR study of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides is described. Optimization of the series was based on in vitro potency against PDE4, inhibition of the LPS-induced production of TNF-alpha in human whole blood and minimizing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6c55e0f85280e7056af4c49b251a4d
https://pubmed.ncbi.nlm.nih.gov/18835163
https://pubmed.ncbi.nlm.nih.gov/18835163
Publikováno v:
Immunotherapy Weekly; 11/5/2024, p566-566, 1p
Publikováno v:
Clinical Trials Week; 5/20/2024, p1048-1048, 1p
Publikováno v:
Bioinformatics; Jan2023, Vol. 39 Issue 1, p1-9, 9p
Publikováno v:
European Journal of Biochemistry. 12/15/94, Vol. 226 Issue 3, p773-782. 10p.
Autor:
Puig, Oscar, I-Ming Wang, Ping Cheng, Zhou, Pris, Roy, Sophie, Cully, Doris, Peters, Mette, Benita, Yair, Thompson, John, Tian-Quan Cai
Publikováno v:
Physiological Genomics; Sep2010, Vol. 42A Issue 1, p24-32, 9p
Publikováno v:
Diabetes; Jun2010 Supplement 1, Vol. 59, pA1-A708, 708p, 1 Black and White Photograph, 4 Diagrams, 398 Charts, 103 Graphs
Autor:
Mu, James, Muise, Eric, Tan, Eugene, Zhihua Li, Azzolina, Barbara, El-Sherbeini, Mohamed, Wong, Kenny, Li, Cai, Thompson, John, Berger, Joel P., Charron, Maureen J., Zhang, Bei B.
Publikováno v:
Diabetes; Jun2007 Supplement 1, Vol. 56, pA285-A285, 1/5p