Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Eric Milot"'
Autor:
Stefania Bottardi, Taylorjade Layne, Ailyn C. Ramòn, Norreen Quansah, Hugo Wurtele, El Bachir Affar, Eric Milot
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Inflammation control is critical during the innate immune response. Such response is triggered by the detection of molecules originating from pathogens or damaged host cells by pattern-recognition receptors (PRRs). PRRs subsequently initiate intra-ce
Externí odkaz:
https://doaj.org/article/32d3186ae4374b99a2993f199c97786d
Autor:
Haithem Barbour, Nadine Sen Nkwe, Benjamin Estavoyer, Clémence Messmer, Mila Gushul-Leclaire, Romain Villot, Maxime Uriarte, Karine Boulay, Sari Hlayhel, Bassel Farhat, Eric Milot, Frédérick A. Mallette, Salima Daou, El Bachir Affar
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106276- (2023)
Summary: Ubiquitination is an important post-translational modification (PTM) that regulates a large spectrum of cellular processes in eukaryotes. Abnormalities in ubiquitin signaling underlie numerous human pathologies including cancer and neurodege
Externí odkaz:
https://doaj.org/article/8268603610614df7a8f26515e242e596
Autor:
Maxime Uriarte, Nadine Sen Nkwe, Roch Tremblay, Oumaima Ahmed, Clémence Messmer, Nazar Mashtalir, Haithem Barbour, Louis Masclef, Marion Voide, Claire Viallard, Salima Daou, Djaileb Abdelhadi, Daryl Ronato, Mohammadjavad Paydar, Anaïs Darracq, Karine Boulay, Nicolas Desjardins-Lecavalier, Przemyslaw Sapieha, Jean-Yves Masson, Mikhail Sergeev, Benjamin H. Kwok, Laura Hulea, Frédérick A. Mallette, Eric Milot, Bruno Larrivée, Hugo Wurtele, El Bachir Affar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Upon starvation, cells coordinate protein disposal to recycle amino acids, although the role of the proteasome has been unclear. Here, the authors show that in the mammalian nucleus, proteasomes form condensates that dissolve following nutrient reple
Externí odkaz:
https://doaj.org/article/b50e1f83646949fdb482fa1c4a35c9f5
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009478 (2021)
The tumor suppressor IKAROS binds and represses multiple NOTCH target genes. For their induction upon NOTCH signaling, IKAROS is removed and replaced by NOTCH Intracellular Domain (NICD)-associated proteins. However, IKAROS remains associated to othe
Externí odkaz:
https://doaj.org/article/ea2abf58fe534e1c8cd38341cea0c3e3
Autor:
Stefania Bottardi, Eric Milot
Publikováno v:
Haematologica, Vol 106, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/15168ef31d48494e8f25d6e02ed6783d
Autor:
Anaïs Darracq, Helen Pak, Vincent Bourgoin, Farah Zmiri, Graham Dellaire, El Bachir Affar, Eric Milot
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008463 (2019)
Nucleophosmin (NPM1) is frequently mutated or subjected to chromosomal translocation in acute myeloid leukemia (AML). NPM protein is primarily located in the nucleus, but the recurrent NPMc+ mutation, which creates a nuclear export signal, is charact
Externí odkaz:
https://doaj.org/article/f994d6816a354d76ae7c455bbb3ae1c1
Autor:
Eric Milot, János G. Filep
Publikováno v:
The Scientific World Journal, Vol 11, Pp 1948-1962 (2011)
Neutrophil granulocytes have the shortest lifespan among leukocytes in the circulation and die via apoptosis. At sites of infection or tissue injury, prolongation of neutrophil lifespan is critical for effective host defense. Apoptosis of inflammator
Externí odkaz:
https://doaj.org/article/11a7a6fe36a0437fa5eb8f313bdd7c92
Autor:
Stefania Bottardi, Lionel Mavoungou, Helen Pak, Salima Daou, Vincent Bourgoin, Yahia A Lakehal, El Bachir Affar, Eric Milot
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004827 (2014)
IKAROS is a critical regulator of hematopoietic cell fate and its dynamic expression pattern is required for proper hematopoiesis. In collaboration with the Nucleosome Remodeling and Deacetylase (NuRD) complex, it promotes gene repression and activat
Externí odkaz:
https://doaj.org/article/d3ddaeeb870c44fe825fcbd53112e0c2
Autor:
Benjamin H. Kwok, Nazar Mashtalir, Jean-Yves Masson, Karine Boulay, Oumaima Ahmed, Frédérick A. Mallette, El Bachir Affar, Maxime Uriarte, Claire Viallard, Anaïs Darracq, Przemyslaw Sapieha, Salima Daou, Bruno Larrivée, Djaileb Abdelhadi, Daryl A. Ronato, Marion Voide, Nadine Sen Nkwe, Laura Hulea, Eric Milot, Hugo Wurtele, Nicolas Desjardins-Lecavalier, Mikhail Sergeev, Haithem Barbour, Louis Masclef, Roch Tremblay, Mohammadjavad Paydar, Clémence Messmer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications
Nature Communications
Eukaryotic cells have evolved highly orchestrated protein catabolic machineries responsible for the timely and selective disposal of proteins and organelles, thereby ensuring amino acid recycling. However, how protein degradation is coordinated with
Publikováno v:
Cell Death & Differentiation. 28:2022-2024