Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Eric Merifield"'
Autor:
Takahiro Fujiwara, Tsukasa Sotoguchi, Edward L. Way, Eric Merifield, John T. Singleton, Melvyn E. Giles, Kevin R. Anderson, James Tornos, Takao Saito, Stéphanie Atkinson, Takaji Matsumoto
Publikováno v:
Organic Process Research & Development. 14:58-71
Routes to (2S)-2-methyltetrahydropyran-4-one of high optical purity starting from readily available chiral pool precursors and suitable for large-scale manufacture are described. In one approach, the key step is cyclisation of (S)-5-hydroxyhex-1-en-3
Autor:
Glyn L. Allsop, Andrea J. Cole, Eric Merifield, Allison J. Noble, Lindsay A. Purdie, Michael A. Pritchett, John T. Singleton, Melvyn E. Giles
Publikováno v:
Organic Process Research & Development. 13:751-759
The development of a convergent synthesis of AR-C123196 is reported in which the alkyl aryl ether linkage was formed by nucleophilic attack of a phenolic hydroxyl group onto a cyclic carbonate. This approach was successfully operated on a multikilogr
Autor:
Marie-Lyne Alcaraz, Lesley A. Humphries, John T. Singleton, Jacob Perkins, Robert Nixon, Eric Merifield, Alison C. Foster, Paul Sadler, Andrew Watts, James Tornos, Richard Kemp, Philip Cornwall, Stéphanie Atkinson, Philip S. Keegan, Duncan M. Gill, Ian A. Woodland, Paul Rowan, Allison J. Noble, Zakariya Patel, D. O'Beirne
Publikováno v:
Organic Process Research & Development. 9:555-569
The development of two efficient strategies for the synthesis of AZD4407 is reported, both of which are considered suitable for large-scale manufacture. In the first approach, 3-bromothiophene is coupled with (2S)-2-methyltetrahydropyran-4-one using
Autor:
Eric Merifield, Eric J. Thomas
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :3269-3283
A total synthesis of cytochalasin D 3 is reported in which the key step is an intramolecular Diels–Alder reaction used to close the 11-membered ring simultaneously introducing the required stereochemistry at four of the stereogenic centres, C(4), C
Publikováno v:
Tetrahedron. 53:9377-9392
Oxidation of the mixture of products obtained by treatment of (S)-2-methylbutanal 8 with the E-but-2-enyldi-isopinocampheylborane prepared from (+)-pinene gave a mixture of homoallylic alcohols from which the major isomer 9 was isolated by chromatogr
Publikováno v:
Tetrahedron: Asymmetry. 7:2809-2812
A novel class of C2-symmetric ligand has been prepared using an intramolecular cyclisation reaction of a diazaphosphole borane complex. Preliminary results of its application to the asymmetric catalysis of hydrogenation, hydrosilylation and allylic s
Publikováno v:
Tetrahedron Letters. 35:2791-2794
Asymmetric inductions of up to 91.5% have been achieved in a palladium catalysed allylic substitution reaction using a new class of enantiomerically pure phosphorus ligand.
Autor:
Philip C. Bulman Page, David Barros, Eric Merifield, Gerasimos A. Rassias, Adel Ardakani, Donald Bethell
Publikováno v:
Scopus-Elsevier
New iminium salt organocatalysts for catalytic asymmetric epoxidation based upon dibenzazepinium salts are reported, providing ee of up to ca 60%.
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :2243-2246
A stereoselective synthesis and X-ray crystal structure of dihydrobenzazaphosphole oxide S(p)R-trans-8, a precursor of a new class of asymmetric ketone reduction catalyst, is described.
Publikováno v:
ChemInform. 25