Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Eric M. Wong"'
Autor:
Hannah J. Uckelmann, Elena L. Haarer, Reina Takeda, Eric M. Wong, Charlie Hatton, Christian Marinaccio, Florian Perner, Masooma Rajput, Noa J.C. Antonissen, Yanhe Wen, Lu Yang, Lorenzo Brunetti, Chun-Wei Chen, Scott A. Armstrong
Publikováno v:
Cancer Discovery. 13:746-765
The dysregulation of developmental and stem cell–associated genes is a common phenomenon during cancer development. Around half of patients with acute myeloid leukemia (AML) express high levels of HOXA cluster genes and MEIS1. Most of these AML cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b913b2bcd54fa923346b6564cf152c03
https://doi.org/10.1158/2159-8290.cd-22-0366
https://doi.org/10.1158/2159-8290.cd-22-0366
Autor:
Scott A. Armstrong, Chun-Wei Chen, Lorenzo Brunetti, Lu Yang, Yanhe Wen, Noa J.C. Antonissen, Masooma Rajput, Florian Perner, Christian Marinaccio, Charlie Hatton, Eric M. Wong, Reina Takeda, Elena L. Haarer, Hannah J. Uckelmann
Supplementary Figure 1. NPM1c degradation leads to differentiation of OCI-AML3 cells.Supplementary Figure 2. NPM1c chromatin targets identified in OCI-AML3-NPM1c-FKBP12 cells and validated by targeted degradation.Supplementary Figure 3. Motif analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207cbdc40a0e1dbaa54f7c4f60899cba
https://doi.org/10.1158/2159-8290.22542664
https://doi.org/10.1158/2159-8290.22542664
Autor:
Scott A. Armstrong, Chun-Wei Chen, Lorenzo Brunetti, Lu Yang, Yanhe Wen, Noa J.C. Antonissen, Masooma Rajput, Florian Perner, Christian Marinaccio, Charlie Hatton, Eric M. Wong, Reina Takeda, Elena L. Haarer, Hannah J. Uckelmann
The dysregulation of developmental and stem cell–associated genes is a common phenomenon during cancer development. Around half of patients with acute myeloid leukemia (AML) express high levels of HOXA cluster genes and MEIS1. Most of these AML cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a3a9e080791e492b2f41cab7a8ad41
https://doi.org/10.1158/2159-8290.c.6550015
https://doi.org/10.1158/2159-8290.c.6550015
Autor:
Scott A. Armstrong, Chun-Wei Chen, Lorenzo Brunetti, Lu Yang, Yanhe Wen, Noa J.C. Antonissen, Masooma Rajput, Florian Perner, Christian Marinaccio, Charlie Hatton, Eric M. Wong, Reina Takeda, Elena L. Haarer, Hannah J. Uckelmann
Table S1. Read normalized ratios of ChIPseq signal of untreated versus dTAG-13 treated OCI-AML3-NPM1c-FKBP12 cells.Table S2. Summary of NPM1c and NPM1 Chromatin Binding Targets.Table S3. Patient info for patient derived xenograft (PDX) models used.Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4205e81f7ebdb51ed4160e09b7711959
https://doi.org/10.1158/2159-8290.22542658
https://doi.org/10.1158/2159-8290.22542658
Autor:
Anilkumar Gopalakrishnapillai, Gerard McGeehan, Jill A Henrich, Haiming Xu, Yaniv Kazansky, Charlie Hatton, Emily B Heikamp, Sonali P. Barwe, Edward A. Kolb, Yanhe Wen, Alex Kentsis, Hannah Uckelmann, Eric M. Wong, Florian Perner, Scott A. Armstrong, Sumiko Takao, Yana Pikman
Publikováno v:
Blood. 139(6)
Translocations involving the NUP98 gene produce NUP98-fusion proteins and are associated with a poor prognosis in acute myeloid leukemia (AML). MLL1 is a molecular dependency in NUP98-fusion leukemia, and therefore we investigated the efficacy of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0faf476c4d84da68cea5a26b10f3094b
https://pubmed.ncbi.nlm.nih.gov/34582559
https://pubmed.ncbi.nlm.nih.gov/34582559
Autor:
Hannah J, Uckelmann, Stephanie M, Kim, Eric M, Wong, Charles, Hatton, Hugh, Giovinazzo, Jayant Y, Gadrey, Andrei V, Krivtsov, Frank G, Rücker, Konstanze, Döhner, Gerard M, McGeehan, Ross L, Levine, Lars, Bullinger, George S, Vassiliou, Scott A, Armstrong
Publikováno v:
Science (New York, N.Y.). 367(6477)
The initiating mutations that contribute to cancer development are sometimes present in premalignant cells. Whether therapies targeting these mutations can eradicate premalignant cells is unclear. Acute myeloid leukemia (AML) is an attractive system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7180ea71d666e5b0c2c3ddecb2afd3f9
https://pubmed.ncbi.nlm.nih.gov/32033969
https://pubmed.ncbi.nlm.nih.gov/32033969