Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Eric M. Towler"'
Autor:
Terry F. Plasse, Christine R. Schar, Jan K. Jensen, Emil Oldenburg, Mark L. Levitt, Eric M. Towler, Eva Louise Lange, Reza Fathi, Danielle T. Abramson
Publikováno v:
Cancer Research. 78:4200-4200
WX-UK1 (the active metabolite of upamostat) was originally developed as an inhibitor of the serine protease urokinase (uPA) with a Ki ~1 uM. To identify more sensitive targets, we performed a bioinformatic analysis of the ~200 human trypsin-like seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5256e7552ed1508c737ab56577a42393
https://doi.org/10.1158/1538-7445.am2018-4200
https://doi.org/10.1158/1538-7445.am2018-4200
Autor:
Robert J. Fisher, Shizuko Sei, Quan-en Yang, Paula E. Roberts, Michael J. Currens, David G. Covell, Lou Henderson, Karen M. Worthy, Alan Rein, Judy A. Mikovits, Robert H. Shoemaker, Thomas G. McCloud, Andrew G. Stephen, Paul Klausmeyer, Eric M. Towler, Rhone K. Akee
Publikováno v:
Biochemical and biophysical research communications. 296(5)
The crucial functions of HIV-1 nucleocapsid-p7 protein (NC-p7) at different stages of HIV replication are dependent on its nucleic acid binding properties. In this study, a search has been made to identify antagonists of the interaction between NC-p7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326f3dc47a4392cf62080afb8acecd99
https://pubmed.ncbi.nlm.nih.gov/12207905
https://pubmed.ncbi.nlm.nih.gov/12207905
Autor:
Lawrence R. Phillips, Robert J. Fisher, Eric M. Towler, Stephen B. Fox, Stephen Campbell, Haleem J. Issaq, Tracy L. Wolfe, Alan Rein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(19)
HIV-1 Gag protein assembles into 100- to 120-nm diameter particles in mammalian cells. Recombinant HIV-1 Gag protein assembles in a fully defined system in vitro into particles that are only 25–30 nm in diameter and that differ significantly in oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e702d94aba531a925801045a95fdb2a
https://pubmed.ncbi.nlm.nih.gov/11526217
https://pubmed.ncbi.nlm.nih.gov/11526217
Autor:
Eric M. Towler, Chong-Hwan Chang, Robert Kuhelj, Bruce D. Korant, Christopher J. Rizzo, Prabhakar K. Jadhav
Publikováno v:
The Journal of biological chemistry. 276(20)
A full-length and C-terminally truncated version of human endogenous retrovirus (HERV)-K10 protease were expressed in Escherichia coli and purified to homogeneity. Both versions of the protease efficiently processed HERV-K10 Gag polyprotein substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457d7dceb179f5d3defc3d233e22c2cd
https://pubmed.ncbi.nlm.nih.gov/11278433
https://pubmed.ncbi.nlm.nih.gov/11278433
Autor:
Lilin Lai, John C. Kappes, Marcus Padow, Robert J. Fisher, Xiaoyun Wu, Yu Chun Zhou, Eric M. Towler
Publikováno v:
AIDS research and human retroviruses. 16(18)
The human endogenous retrovirus, type K (HERV-K) represents the most biologically active form of known retroelements present in the human genome. Several HERV-K genomes have transcriptionally active open reading frames and encode their own protease (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a05e165e3230cc197e0ace8c8da4ea0
https://pubmed.ncbi.nlm.nih.gov/11153080
https://pubmed.ncbi.nlm.nih.gov/11153080
Publikováno v:
Analytical biochemistry. 279(1)
We have developed a complete system for discovery of lead compounds as inhibitors of creatine kinase B. In this article, we describe production and purification of the recombinant protein, conditions and features of an optimized high-throughput scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9e7a07dcbde5f45eda9ad67b5f6d81
https://pubmed.ncbi.nlm.nih.gov/10683236
https://pubmed.ncbi.nlm.nih.gov/10683236
Autor:
John W. Erickson, Christopher Jones, Dong Xie, Nikolaus Mueller-Lantzsch, Elena Gustschina, Sergei V. Gulnik, Marlies Sauter, Christine Debouck, Terry R. Sumpter, T. N. Bhat, Nicole Robertson, Eric M. Towler
Publikováno v:
Biochemistry. 37(49)
To investigate the biochemical properties of the protease encoded by the human endogenous retrovirus, K10 (HERV-K), 213 amino acids of the 3'-end of the HERV-K protease (PR) open reading frame were expressed in Escherichia coli. Autocatalytic cleavag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce8eb0c0740b54189f9494c6b49f821
https://pubmed.ncbi.nlm.nih.gov/9860826
https://pubmed.ncbi.nlm.nih.gov/9860826
Publikováno v:
Biochemistry. 37(31)
The structural basis of ligand specificity in human immunodeficiency virus (HIV) protease has been investigated by determining the crystal structures of three chimeric HIV proteases complexed with SB203386, a tripeptide analogue inhibitor. The chimer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ae200e3bbff08c83c76132a44baebe
https://pubmed.ncbi.nlm.nih.gov/9692985
https://pubmed.ncbi.nlm.nih.gov/9692985
Publikováno v:
Current opinion in biotechnology. 9(1)
Examination of the literature for the period of this review revealed nearly two hundred citations that employed surface plasmon resonance (SPR) spectroscopy using BIAcore technology to evaluate biospecific interactions, demonstrating the increasing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8b4ad663c52bd3c8e8350fbe3a0159
https://pubmed.ncbi.nlm.nih.gov/9503595
https://pubmed.ncbi.nlm.nih.gov/9503595
Publikováno v:
Biochemistry. 36(17)
We have investigated the inhibitor specificity for the proteases of the human immunodeficiency viruses, types 1 and 2. Using a series of related inhibitors, the P1' side chain was confirmed to play a significant role in determining both the absolute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8ae35b228d31a2757127fd44f23ee9
https://pubmed.ncbi.nlm.nih.gov/9136873
https://pubmed.ncbi.nlm.nih.gov/9136873