Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Eric M. Tam"'
Autor:
Jay S Fine, Louis Matis, Stella Martomo, Xingyue An, Mohosin Sarkar, Abudukadier Abulizi, Guixian Jin, Evelyn Teran, Danielle Klaskin, Maria Hackett, Hayden Karp, Julio Rodriguez, Sonali Dhindwal, Changqing Yuan, Zengzu Lai, Jennifer Zeiger, Amber Fearnley, Oksana A Sergeeva, Eric M Tam, Tracy Lichter, Jeremy S Myers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/26c6651b0b594272bbdce220e09fc635
Autor:
Jay S Fine, Louis Matis, Stella Martomo, Mohosin Sarkar, Abudukadier Abulizi, Guixian Jin, Evelyn Teran, Danielle Klaskin, Hayden Karp, Julio Rodriguez, Sonali Dhindwal, Zengzu Lai, Jennifer Zeiger, Amber Fearnley, Oksana A Sergeeva, Eric M Tam, Afsana Sabrin, Tracy Lichter, Kristen Metzler, Kyla Joinville, Jeremy Sh Myers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/e73da3c51c3e4760977b75a612d36cdc
Autor:
Mohosin Sarkar, Eric M. Tam, Guixian Jin, Shu Shien Chin, Abudukadier Abulizi, Oksana A. Sergeeva, Zengzu Lai, Evelyn Teran, Hayden Karp, Danielle Klaskin, Nana Adjoa Pels, Xingyue An, Jennifer Ziegler, Changqing Yuan, Maria Hackettt, Sonali Dhindwal, Amber Fearnley, Julio Rodriguez, Louis Matis, Jay S. Fine, Jeremy S. Myers
Publikováno v:
Cancer Research. 83:2971-2971
Bispecific antibodies which bind a tumor antigen and the CD3 heterodimer of the T cell receptor to form a synthetic immunological synapse represent a class of T cell engagers that has been clinically validated with the approvals of blinatumomab (Blin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::119b5ba4e68877cfdbd7d30211801e41
https://doi.org/10.1158/1538-7445.am2023-2971
https://doi.org/10.1158/1538-7445.am2023-2971
Autor:
Alexander Koshkaryev, Walid S. Kamoun, Gang Sun, Vasileios Askoxylakis, Lia Luus, Ross B. Fulton, James F. Sampson, Eric M. Tam, Andrew J. Sawyer, Zhaohua Richard Huang, Daryl C. Drummond, Anne-Sophie Dugast, Michael Santiago, James Suchy, Stephanie Grabow
Publikováno v:
Molecular Cancer Therapeutics. 19:270-281
Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti–PD-1/L1 agents in combination with taxane-based chemotherapy in non–small cell lung cancer and triple-negative breast cancer. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d1de2be371c87bef464a4ffd8c4529
https://doi.org/10.1158/1535-7163.mct-19-0414
https://doi.org/10.1158/1535-7163.mct-19-0414
Antibody-mediated targeting of TNFR2 activates CD8 + T cells in mice and promotes antitumor immunity
Autor:
Wenlian Qiao, James Qiu, James Lulo, Jian Tang, Anne-Sophie Dugast, Ross B. Fulton, Galina Craig, Stephanie Grabow, Maja Razlog, James F. Sampson, Eric M. Tam, Sonia Feau, Alexander Koshkaryev, Neeraj Kohli, Kathy Zhang, Yang Jiao, Lia Luus, Adam Camblin, Jennifer Richards, Christina S. F. Wong, Daryl C. Drummond, James Suchy, Aniela Jakubowski, Michael Croft, Marco Muda, James D. Marks, Elizabeth Hutto, Vinodh B. Kurella, Yu Zhou, Andreas Raue, Hong Zhang, Lihui Xu, Fabien Dépis, Sandeep Kumar, Violette Paragas
Publikováno v:
Science Translational Medicine. 11
Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (Tregs) in autoimm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5923342bbcf0a08d5a53784115771df
https://doi.org/10.1126/scitranslmed.aax0720
https://doi.org/10.1126/scitranslmed.aax0720
Autor:
Eric M, Tam, Ross B, Fulton, James F, Sampson, Marco, Muda, Adam, Camblin, Jennifer, Richards, Alexander, Koshkaryev, Jian, Tang, Vinodh, Kurella, Yang, Jiao, Lihui, Xu, Kathy, Zhang, Neeraj, Kohli, Lia, Luus, Elizabeth, Hutto, Sandeep, Kumar, James, Lulo, Violette, Paragas, Christina, Wong, James, Suchy, Stephanie, Grabow, Anne-Sophie, Dugast, Hong, Zhang, Fabien, Depis, Sonia, Feau, Aniela, Jakubowski, Wenlian, Qiao, Galina, Craig, Maja, Razlog, James, Qiu, Yu, Zhou, James D, Marks, Michael, Croft, Daryl C, Drummond, Andreas, Raue
Publikováno v:
Science translational medicine. 11(512)
Tumor necrosis factor receptor 2 (TNFR2) is the alternate receptor for TNF and can mediate both pro- and anti-inflammatory activities of T cells. Although TNFR2 has been linked to enhanced suppressive activity of regulatory T cells (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37f83727e9fb0372906f1265c50b70b8
https://pubmed.ncbi.nlm.nih.gov/31578241
https://pubmed.ncbi.nlm.nih.gov/31578241
Publikováno v:
Cancer Research. 75:B1-29
The trimeric TNF-related apoptosis-inducing ligand (TRAIL) is an endogenous ligand that binds to trimeric death receptors (DR4/5). TRAIL is known to induce apoptosis mainly in malignant cells while normal cells remain unaffected. This makes TRAIL a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a9fc94dd34edcc58da1aceb90f6bcfe
https://doi.org/10.1158/1538-7445.compsysbio-b1-29
https://doi.org/10.1158/1538-7445.compsysbio-b1-29
Autor:
James F. Sampson, Vinodh B. Kurella, Violette Paragas, Sandeep Kumar, James E. Lulo, James A. Qiu, Maja Razlog, Ross B. Fulton, Adam J. Camblin, Jennifer M. Richards, Christina S. Wong, Alexander Koshkaryev, James J. Suchy, Stephanie Grabow, Marco Muda, Andreas Raue, Daryl C. Drummond, Eric M. Tam
Publikováno v:
Cancer Research. 79:555-555
TNFR2 is an emerging therapeutic target in immuno-oncology. We have previously shown that an agonistic mouse TNFR2 antibody was able to activate CD8+ T cells in vitro and has anti-tumor activity in multiple syngeneic mouse tumor models. This activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c9f14a39bb58f6cf7c277d0e6b2529a
https://doi.org/10.1158/1538-7445.am2019-555
https://doi.org/10.1158/1538-7445.am2019-555
Autor:
Maja Razlog, James F. Sampson, Adam Camblin, Eric M. Tam, Alexander Koshkaryev, Ross B. Fulton, Lia Luus, Christina Wong, Marco Muda, Violette Paragas, Yang Jiao, Lihui Xu, Jennifer Richards, Andreas Raue, Daryl C. Drummond
Publikováno v:
Cancer Research. 79:3270-3270
TNFR2 is a member of the TNF receptor superfamily that is upregulated upon T cell activation and is highly expressed by tumor-infiltrating effector and regulatory T cells. We investigated TNFR2 levels on T cells in syngeneic mouse tumor models and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74f5940c36ebe9991da8b872365d007f
https://doi.org/10.1158/1538-7445.am2019-3270
https://doi.org/10.1158/1538-7445.am2019-3270
Autor:
Christina Wong, Sara Ghassemifar, Daryl C. Drummond, Maja Razlog, Stephanie Grabow, Alexander Koshkaryev, Andrew J. Sawyer, James Suchy, Jennifer Richards, Eric M. Tam
Publikováno v:
Cancer Research. 79:2491-2491
Early attempts at using TNF superfamily members for anticancer therapies, TNF and FAS, led to serious systemic toxicities. However, the discovery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) introduced an agonist capable of kill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2b19641ec0503d80783d6a36a522831
https://doi.org/10.1158/1538-7445.am2019-2491
https://doi.org/10.1158/1538-7445.am2019-2491