Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Eric M. Sturgill"'
Autor:
Siddhartha Sen, Tony Taldone, Sarah Brennan, Michael W. Becker, John Koren, Erica M. Gomes-DaGama, Stephen D. Nimer, Ross L. Levine, Hongliang Zong, Eloisi Caldas-Lopes, Gabriela Chiosis, Monica L. Guzman, Alexander Gozman, Charles M. Rudin, Anna Rodina, Gail J. Roboz, Ari Melnick, Eric M. Sturgill, Stefan O. Ochiana
Publikováno v:
Cell reports
Cell Reports, Vol 13, Iss 10, Pp 2159-2173 (2015)
Cell Reports, Vol 13, Iss 10, Pp 2159-2173 (2015)
SUMMARY Acute myeloid leukemia (AML) is a heterogeneous and fatal disease with an urgent need for improved therapeutic regimens given that most patients die from relapsed disease. Irrespective of mutation status, the development of aggressive leukemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873c573f3387ec4def3532ec7435b917
Autor:
Eric M. Sturgill, Monica L. Guzman
Publikováno v:
Cancer Research. 74:4793-4793
Selective expression of PKM2 and its unique ability to switch between states of enzymatic activity are exploited by proliferating cells; limiting the generation of pyruvate available for oxidative phosphorylation and in turn providing a robust store
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8c914f2ee51c5443ed2435642c1730d
https://doi.org/10.1158/1538-7445.am2014-4793
https://doi.org/10.1158/1538-7445.am2014-4793
Autor:
Eric M. Sturgill, Monica L. Guzman
Publikováno v:
Blood. 122:5406-5406
A common characteristic among nearly all cancers, including leukemia, is the cell’s metabolic proclivity for glycolysis over the more energy efficient process of oxidative phosphorylation (OXPHOS) in the presence of oxygen. This altered state of ae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::528abe1af2c8ca7298d0400105ca3c39
https://doi.org/10.1182/blood.v122.21.5406.5406
https://doi.org/10.1182/blood.v122.21.5406.5406