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Integrating Experimental and Analytic Approaches to Improve Data Quality in Genome-wide RNAi Screens
Autor:
Eric M. Stec, Eric N. Johnson, Jayne Chin, Adam Gates, Dan Holder, Lyndon J. Mitnaul, Berta Strulovici, Marc Ferrer, Jenny Tian, Priya Kunapuli, Joseph F. Heyse, Shane Marine, Xiaohua Douglas Zhang, Amy S. Espeseth
Publikováno v:
SLAS Discovery. 13:378-389
RNA interference (RNAi) not only plays an important role in drug discovery but can also be developed directly into drugs. RNAi high-throughput screening (HTS) biotechnology allows us to conduct genome-wide RNAi research. A central challenge in genome