Výsledky vyhledávání - "Eric M. SHOOTER"

Akademický článek

Recessive, but not dominant, mutations in peripheral myelin protein 22 gene show unique patterns of aggregation and intracellular trafficking

Autor: Ning Liu, Junji Yamauchi, Eric M. Shooter

Publikováno v: Neurobiology of Disease, Vol 17, Iss 2, Pp 300-309 (2004)

A characteristic feature of mouse models of the peripheral neuropathies caused by dominant mutations in peripheral myelin protein 22 (pmp22) is the appearance, in Schwann cells, of pmp22 aggregates. Using a set of dominant and recessive pmp22 mutatio

Externí odkaz: https://doaj.org/article/8bdd1bfe5c004330bc1eaf2fd5464a75

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Akademický článek

Aggresome Formation in Neuropathy Models Based on Peripheral Myelin Protein 22 Mutations

Autor: Mary C. Ryan, Eric M. Shooter, Lucia Notterpek

Publikováno v: Neurobiology of Disease, Vol 10, Iss 2, Pp 109-118 (2002)

Alterations in peripheral myelin protein 22 (PMP22) gene expression are associated with demyelinating peripheral neuropathies. Overexpression of wild type (wt) PMP22 or inhibition of proteasomal degradation lead to the formation of aggresomes, intrac

Externí odkaz: https://doaj.org/article/ee47366d9cd9464a8967c0de60d60003

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Akademický článek

Translational Control of Ribosomal Protein L4 mRNA Is Required for Rapid Neurite Regeneration

Autor: Jeffery L. Twiss, Deanna S. Smith, Bieshia Chang, Eric M. Shooter

Publikováno v: Neurobiology of Disease, Vol 7, Iss 4, Pp 416-428 (2000)

Under some circumstances neurons can be primed to rapidly regenerate injured neuritic processes independent of new gene expression. Such transcription-independent neurite extension occurs in adult rat sensory neurons cultured after sciatic nerve crus

Externí odkaz: https://doaj.org/article/fef61fd4f209431c879c36e6db4f59ec

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Akademický článek

PMP22 Accumulation in Aggresomes: Implications for CMT1A Pathology

Autor: Lucia Notterpek, Mary C. Ryan, Andreas R. Tobler, Eric M. Shooter

Publikováno v: Neurobiology of Disease, Vol 6, Iss 5, Pp 450-460 (1999)

Peripheral myelin protein 22 (PMP22) is a 22-kDa glycoprotein mainly expressed by Schwann cells (SCs). Duplication or deletion of the PMP22 gene locus is associated with heritable peripheral neuropathies suggesting that the correct level of PMP22 pro

Externí odkaz: https://doaj.org/article/d95f369203bf4da884dcb13d1d47699d

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Binding of nerve growth factor to its p75 receptor in stressed cells induces selective IκB-β degradation and NF-κB nuclear translocation

Autor: Jose Miguel Cosgaya, Eric M. Shooter

Publikováno v: Journal of Neurochemistry. 79:391-399

Nerve growth factor (NGF) regulates the activity of the transcription factor NF-κB (nuclear factor-κB) through its low affinity receptor, p75. In the present study we found that NGF binding to p75 induces nuclear translocation of p65 and increases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54be2712afdd13b5a32460cfcad2afa2
https://doi.org/10.1046/j.1471-4159.2001.00573.x

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Depleting endogenous neurotrophin-3 enhances myelin formation in the Trembler-J mouse, a model of a peripheral neuropathy

Autor: Eric M. Shooter, Ravi J Tolwani, David Tsao, Sushama Varma, Ning Liu

Publikováno v: Journal of Neuroscience Research. 85:2863-2869

The heterozygous Trembler-J (TrJ/+) mouse, containing a point mutation in the peripheral myelin protein 22 (Pmp22) gene, is characterized by severe hypomyelination and is a representative model of Charcot-Marie-Tooth 1A (CMT1A) disease/Dejerine-Sotta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfcef1dba9ec5197d5ba8a33d0d4f0b
https://doi.org/10.1002/jnr.21388

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The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration

Autor: Yuki Miyamoto, Eric M. Shooter, Jonah R. Chan, Gozoh Tsujimoto, Junji Yamauchi

Publikováno v: Proceedings of the National Academy of Sciences. 102:5198-5203

During the development of the peripheral nervous system, Schwann cells, the myelin-forming glia, migrate along axons before initiating myelination. We previously demonstrated that endogenous neurotrophin-3 (NT3) acting through the TrkC tyrosine kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c301b88414fd6df7b7fe647f4b14bf56
https://doi.org/10.1073/pnas.0501160102

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Recessive, but not dominant, mutations in peripheral myelin protein 22 gene show unique patterns of aggregation and intracellular trafficking

Autor: Eric M. Shooter, Ning Liu, Junji Yamauchi

Publikováno v: Neurobiology of Disease, Vol 17, Iss 2, Pp 300-309 (2004)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03641fef824dd52da1284e0c9f943af
http://www.sciencedirect.com/science/article/pii/S0969996104001524

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Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases

Autor: Eric M. Shooter, Junji Yamauchi, Jonah R. Chan

Publikováno v: Proceedings of the National Academy of Sciences. 101:8774-8779

Neurotrophins are recognized widely as essential factors in the developing nervous system. Previously, we demonstrated that neurotrophin 3 activation of TrkC inhibits Schwann cell myelination and enhances the migration of primary Schwann cells throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb606fda0a87a8de54270113109f378
https://doi.org/10.1073/pnas.0402795101

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