Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Eric M. Mendenhall"'
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination assoc
Externí odkaz:
https://doaj.org/article/1010cb2b07ac42418e6fb9795f6fb27c
Autor:
Joel Rozowsky, Jiahao Gao, Beatrice Borsari, Yucheng T. Yang, Timur Galeev, Gamze Gürsoy, Charles B. Epstein, Kun Xiong, Jinrui Xu, Tianxiao Li, Jason Liu, Keyang Yu, Ana Berthel, Zhanlin Chen, Fabio Navarro, Maxwell S. Sun, James Wright, Justin Chang, Christopher J.F. Cameron, Noam Shoresh, Elizabeth Gaskell, Jorg Drenkow, Jessika Adrian, Sergey Aganezov, François Aguet, Gabriela Balderrama-Gutierrez, Samridhi Banskota, Guillermo Barreto Corona, Sora Chee, Surya B. Chhetri, Gabriel Conte Cortez Martins, Cassidy Danyko, Carrie A. Davis, Daniel Farid, Nina P. Farrell, Idan Gabdank, Yoel Gofin, David U. Gorkin, Mengting Gu, Vivian Hecht, Benjamin C. Hitz, Robbyn Issner, Yunzhe Jiang, Melanie Kirsche, Xiangmeng Kong, Bonita R. Lam, Shantao Li, Bian Li, Xiqi Li, Khine Zin Lin, Ruibang Luo, Mark Mackiewicz, Ran Meng, Jill E. Moore, Jonathan Mudge, Nicholas Nelson, Chad Nusbaum, Ioann Popov, Henry E. Pratt, Yunjiang Qiu, Srividya Ramakrishnan, Joe Raymond, Leonidas Salichos, Alexandra Scavelli, Jacob M. Schreiber, Fritz J. Sedlazeck, Lei Hoon See, Rachel M. Sherman, Xu Shi, Minyi Shi, Cricket Alicia Sloan, J Seth Strattan, Zhen Tan, Forrest Y. Tanaka, Anna Vlasova, Jun Wang, Jonathan Werner, Brian Williams, Min Xu, Chengfei Yan, Lu Yu, Christopher Zaleski, Jing Zhang, Kristin Ardlie, J Michael Cherry, Eric M. Mendenhall, William S. Noble, Zhiping Weng, Morgan E. Levine, Alexander Dobin, Barbara Wold, Ali Mortazavi, Bing Ren, Jesse Gillis, Richard M. Myers, Michael P. Snyder, Jyoti Choudhary, Aleksandar Milosavljevic, Michael C. Schatz, Bradley E. Bernstein, Roderic Guigó, Thomas R. Gingeras, Mark Gerstein
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource of 1,635 open-access datasets from four don
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464939170ba93b49ee4e474d325702f1
http://hdl.handle.net/10230/56942
http://hdl.handle.net/10230/56942
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Autor:
Ming Du, Ning Peng, Jamie R Wangen, Jianguo Chen, Rachel Green, Venkateshwar Mutyam, Yao Li, Kari Thrasher, Corinne E. Augelli-Szafran, Jerome Mahiou, Feng Liang, Jyoti Sharma, Lianwu Fu, Candice J. Coppola, Kim M. Keeling, Martin Mense, Eric M. Mendenhall, Jeong S. Hong, Hermann Bihler, Liping Tang, Robert Bostwick, Eric J. Sorscher, Bini Mathew, Josef Saltz, Steven M. Rowe, Andras Rab, Kaimao Liu, David M. Bedwell, Mark J. Suto, Eric Wong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation t
Autor:
Barbara J. Wold, Laurel A. Brandsmeier, Jeremy W. Prokop, Richard M. Myers, Shan Jiang, Mark Mackiewicz, Sarah Meadows, Ali Mortazavi, Camden Jansen, Eric M. Mendenhall, Daniel Savic, Ryne C. Ramaker, Candice J. Coppola, Andrew A. Hardigan, Surya B. Chhetri, Emma C. Dean, E. Christopher Partridge, Kimberly M. Newberry, C. Luke Messer, Say-Tar Goh
Publikováno v:
Nature
Transcription factors are DNA-binding proteins that have key roles in gene regulation1,2. Genome-wide occupancy maps of transcriptional regulators are important for understanding gene regulation and its effects on diverse biological processes3–6. H
Autor:
Shih Hsing Leir, Monali NandyMazumdar, Shiyi Yin, Eric M. Mendenhall, Kay-Marie Lamar, Jenny L. Kerschner, Hannah Swahn, Jey Sabith Ebron, Ann Harris, Candice J. Coppola
Publikováno v:
Journal of Cellular and Molecular Medicine
E74‐like factor 5 (ELF5) and ETS‐homologous factor (EHF) are epithelial selective ETS family transcription factors (TFs) encoded by genes at chr11p13, a region associated with cystic fibrosis (CF) lung disease severity. EHF controls many key proc
Autor:
Joel Rozowsky, Jorg Drenkow, Yucheng T Yang, Gamze Gursoy, Timur Galeev, Beatrice Borsari, Charles B Epstein, Kun Xiong, Jinrui Xu, Jiahao Gao, Keyang Yu, Ana Berthel, Zhanlin Chen, Fabio Navarro, Jason Liu, Maxwell S Sun, James Wright, Justin Chang, Christopher JF Cameron, Noam Shoresh, Elizabeth Gaskell, Jessika Adrian, Sergey Aganezov, François Aguet, Gabriela Balderrama-Gutierrez, Samridhi Banskota, Guillermo Barreto Corona, Sora Chee, Surya B Chhetri, Gabriel Conte Cortez Martins, Cassidy Danyko, Carrie A Davis, Daniel Farid, Nina P Farrell, Idan Gabdank, Yoel Gofin, David U Gorkin, Mengting Gu, Vivian Hecht, Benjamin C Hitz, Robbyn Issner, Melanie Kirsche, Xiangmeng Kong, Bonita R Lam, Shantao Li, Bian Li, Tianxiao Li, Xiqi Li, Khine Zin Lin, Ruibang Luo, Mark Mackiewicz, Jill E Moore, Jonathan Mudge, Nicholas Nelson, Chad Nusbaum, Ioann Popov, Henry E Pratt, Yunjiang Qiu, Srividya Ramakrishnan, Joe Raymond, Leonidas Salichos, Alexandra Scavelli, Jacob M Schreiber, Fritz J Sedlazeck, Lei Hoon See, Rachel M Sherman, Xu Shi, Minyi Shi, Cricket Alicia Sloan, J Seth Strattan, Zhen Tan, Forrest Y Tanaka, Anna Vlasova, Jun Wang, Jonathan Werner, Brian Williams, Min Xu, Chengfei Yan, Lu Yu, Christopher Zaleski, Jing Zhang, Kristin Ardlie, J Michael Cherry, Eric M Mendenhall, William S Noble, Zhiping Weng, Morgan E Levine, Alexander Dobin, Barbara Wold, Ali Mortazavi, Bing Ren, Jesse Gillis, Richard M Myers, Michael P Snyder, Jyoti Choudhary, Aleksandar Milosavljevic, Michael C Schatz, Roderic Guigó, Bradley E Bernstein, Thomas R Gingeras, Mark Gerstein
Understanding how genetic variants impact molecular phenotypes is a key goal of functional genomics, currently hindered by reliance on a single haploid reference genome. Here, we present the EN-TEx resource of personal epigenomes, for ∼25 tissues a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f293c3be99001dfcca0596fbe318c048
https://doi.org/10.1101/2021.04.26.441442
https://doi.org/10.1101/2021.04.26.441442
Autor:
Carrie A. Davis, Charles B. Epstein, Eric L. Van Nostrand, Valentina Snetkova, Michael J. Purcaro, Manolis Kellis, Yupeng He, Henry Pratt, John A. Stamatoyannopoulos, Ali Mortazavi, Xintao Wei, Michael Snyder, Jialing Zhang, Job Dekker, Anshul Kundaje, Shaimae I. Elhajjajy, Gene W. Yeo, Jessica Halow, Peggy J. Farnham, Kevin P. White, Xiaofeng Wang, Eric M. Mendenhall, Diane E. Dickel, John L. Rinn, Thomas R. Gingeras, Yin Shen, Juan Carlos Rivera-Mulia, David U. Gorkin, William Stafford Noble, Rajinder Kaul, David M. Gilbert, Jill Moore, Xiao-Ou Zhang, Peter Freese, Bing Ren, Joseph R. Ecker, Eric Lécuyer, Christopher B. Burge, Ross C. Hardison, Jing Zhang, Zhiping Weng, Richard M. Myers, Robert J. Klein, Brian A. Williams, Alexander Dobin, Alec Victorsen, Noam Shoresh, Joel Rozowsky, Jack Huey, Bradley E. Bernstein, Mark Mackiewicz, Roderic Guigó, Axel Visel, Brenton R. Graveley, J. Michael Cherry, Trupti Kawli, Mark Gerstein, Cheryl A. Keller, Barbara J. Wold, Jessika Adrian, Len A. Pennacchio, Florencia Pauli-Behn, Surya B. Chhetri
Publikováno v:
Moore, Jill E; Purcaro, Michael J; Pratt, Henry E; Epstein, Charles B; Shoresh, Noam; Adrian, Jessika; Kawli, Trupti; Davis, Carrie A; Dobin, Alexander; Kaul, Rajinder; Halow, Jessica; Van Nostrand, Eric L; Freese, Peter; Gorkin, David U; Shen, Yin; He, Yupeng; Mackiewicz, Mark; Pauli-Behn, Florencia; Williams, Brian A; Mortazavi, Ali; ... (2020). Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature, 583(7818), pp. 699-710. Springer Nature 10.1038/s41586-020-2493-4
Nature
Nature, vol. 583, no. 7818, pp. 699-710
Nature
Nature, vol. 583, no. 7818, pp. 699-710
The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c895e469a429f18f75d20f5b0e64d2e
https://boris.unibe.ch/146110/1/s41586-020-2493-4.pdf
https://boris.unibe.ch/146110/1/s41586-020-2493-4.pdf
Autor:
Sarah K, Meadows, Laurel A, Brandsmeier, Kimberly M, Newberry, Michael J, Betti, Amy S, Nesmith, Mark, Mackiewicz, E Christopher, Partridge, Eric M, Mendenhall, Richard M, Myers
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2117
Chromatin immunoprecipitation followed by next-generation DNA sequencing (ChIP-seq) has been used to identify transcription factor (TF) binding proteins throughout the genome. Unfortunately, this approach traditionally requires commercially available
Autor:
Laurel A. Brandsmeier, Mark Mackiewicz, Amy S. Nesmith, Eric M. Mendenhall, Richard M. Myers, Sarah Meadows, Michael J Betti, Kimberly M. Newberry, E. Christopher Partridge
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603000
Chromatin immunoprecipitation followed by next-generation DNA sequencing (ChIP-seq) has been used to identify transcription factor (TF) binding proteins throughout the genome. Unfortunately, this approach traditionally requires commercially available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::384c984eb0a3c9a205c14ac264c72f70
https://doi.org/10.1007/978-1-0716-0301-7_1
https://doi.org/10.1007/978-1-0716-0301-7_1
Autor:
Eric M Mendenhall, Richard P Koche, Thanh Truong, Vicky W Zhou, Biju Issac, Andrew S Chi, Manching Ku, Bradley E Bernstein
Publikováno v:
PLoS Genetics, Vol 6, Iss 12, p e1001244 (2010)
Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements by DNA binding proteins associ
Externí odkaz:
https://doaj.org/article/b2309a68bdfd4098a81ca154a9a383e2