Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Eric M. Lynch"'
Autor:
Eric M. Lynch, Heather Hansen, Lauren Salay, Madison Cooper, Stepan Timr, Justin M. Kollman, Bradley A. Webb
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Phosphofructokinase-1 (PFK1) catalyzes the rate-limiting step of glycolysis, committing glucose to conversion into cellular energy. PFK1 is highly regulated to respond to the changing energy needs of the cell. In bacteria, the structural bas
Externí odkaz:
https://doaj.org/article/2b92b0bfffbc4f84a0aa5d7fec0ee65d
Autor:
Jacqueline C. Simonet, Maya J. Foster, Eric M. Lynch, Justin M. Kollman, Emmanuelle Nicholas, Alana M. O'Reilly, Jeffrey R. Peterson
Publikováno v:
Biology Open, Vol 9, Iss 7 (2020)
Polymerization of metabolic enzymes into micron-scale assemblies is an emerging mechanism for regulating their activity. CTP synthase (CTPS) is an essential enzyme in the biosynthesis of the nucleotide CTP and undergoes regulated and reversible assem
Externí odkaz:
https://doaj.org/article/86b5f1a866c8437689343481968ec4b5
Autor:
Jesse M Hansen, Avital Horowitz, Eric M Lynch, Daniel P Farrell, Joel Quispe, Frank DiMaio, Justin M Kollman
Publikováno v:
eLife, Vol 10 (2021)
Many metabolic enzymes self-assemble into micron-scale filaments to organize and regulate metabolism. The appearance of these assemblies often coincides with large metabolic changes as in development, cancer, and stress. Yeast undergo cytoplasmic aci
Externí odkaz:
https://doaj.org/article/e958299121e7450aac97494ed011adbf
Autor:
Xun X Bao, Christos Spanos, Tomoko Kojidani, Eric M Lynch, Juri Rappsilber, Yasushi Hiraoka, Tokuko Haraguchi, Kenneth E Sawin
Publikováno v:
eLife, Vol 7 (2018)
Non-centrosomal microtubule organizing centers (MTOCs) are important for microtubule organization in many cell types. In fission yeast Schizosaccharomyces pombe, the protein Mto1, together with partner protein Mto2 (Mto1/2 complex), recruits the γ-t
Externí odkaz:
https://doaj.org/article/e5df852de354497887391bb9dde2001c
Publikováno v:
Curr Opin Cell Biol
Compartmentalization of metabolic enzymes through protein-protein interactions is an emerging mechanism for localizing and regulating metabolic activity. Self-assembly into linear filaments is a common strategy for cellular compartmentalization of en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0a0540005175adc2ffd278a353a11c
https://doi.org/10.1016/j.ceb.2020.04.006
https://doi.org/10.1016/j.ceb.2020.04.006
Autor:
William A. Catterall, Qi Xu, Daohua Jiang, Atsuko Uyeda, Jiayi Dou, Tamer M. Gamal El-Din, Tomoaki Matsuura, Yang Hsia, David Baker, Dan Ma, Matthew J. Bick, T. J. Brunette, Justin M. Kollman, Chunfu Xu, Hua Bai, Eric M. Lynch, Po-Ssu Huang, Gabriella Reggiano, Peilong Lu, Scott E. Boyken, Matthew C. Johnson, Xue Y. Pei, Frank DiMaio, Lance Stewart, Ben F. Luisi
Publikováno v:
Nature
Transmembrane channels and pores have key roles in fundamental biological processes1 and in biotechnological applications such as DNA nanopore sequencing2-4, resulting in considerable interest in the design of pore-containing proteins. Synthetic amph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b9825492d180b0abadeeb58f81bed8
http://europepmc.org/articles/PMC7483984
http://europepmc.org/articles/PMC7483984
Autor:
Jesse M Hansen, Joshua J McElwee, Eric M. Lynch, Kevin D Kreutter, Gydo C. P. van Zundert, Michael A. DiMattia, Joel Quispe, Andreas Verras, Steven K. Albanese, Neelu Kaila, Justin M. Kollman, Angela V. Toms, Madison Arza Kennedy, Kenneth W. Borrelli
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance An effective immune response depends on the proliferation of T cells, a process that requires the enzyme CTP synthase 1 (CTPS1). Individuals lacking CTPS1 due to a rare genetic disorder exhibit severe immunodeficiencies but lack other ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e970023a4f204df8bc5bb1e49ba04c6
https://doi.org/10.1073/pnas.2107968118
https://doi.org/10.1073/pnas.2107968118
Autor:
Daniel P. Farrell, Avital Horowitz, Justin M. Kollman, Joel Quispe, Frank DiMaio, Eric M. Lynch, Jesse M Hansen
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Many metabolic enzymes self-assemble into micron-scale filaments to organize and regulate metabolism. The appearance of these assemblies often coincides with large metabolic changes as in development, cancer, and stress. Yeast undergo cytoplasmic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59092b624ca4b0ff57d668d32c7975df
https://doi.org/10.1101/2021.08.25.457724
https://doi.org/10.1101/2021.08.25.457724
Autor:
Christopher D. Thouvenel, Silvia Portugal, Eric M. Lynch, Mary F. Fontana, Marie Pancera, Suruchi Singh, Jason Netland, Kennidy K Takehara, Marion Pepper, Neil P. King, Peter D. Crompton, Gladys J. Keitany, Yu Chen, Carole A. Long, Akshay T. Krishnamurty, Kazutoyo Miura, David J. Rawlings, Marcos C. Miranda, Justin M. Kollman
Publikováno v:
The Journal of Experimental Medicine
Thouvenel et al. isolate BCR sequences from Plasmodium-specific IgM+ human memory B cells, expressing them as both IgM and IgG molecules. Multimerization confers superior antigen binding and parasite restriction, highlighting an important role for me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05081f2f23d9d75c33be1816f0e6e347
https://doi.org/10.1084/jem.20200942
https://doi.org/10.1084/jem.20200942