Zobrazeno 1 - 10
of 736
pro vyhledávání: '"Eric M Reiman"'
Autor:
Gemma Salvadó, Rik Ossenkoppele, Nicholas J Ashton, Thomas G Beach, Geidy E Serrano, Eric M Reiman, Henrik Zetterberg, Niklas Mattsson‐Carlgren, Shorena Janelidze, Kaj Blennow, Oskar Hansson
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp 1-16 (2023)
Abstract Several promising plasma biomarkers for Alzheimer's disease have been recently developed, but their neuropathological correlates have not yet been fully determined. To investigate and compare independent associations between multiple plasma
Externí odkaz:
https://doaj.org/article/adc3e327988745318065d88c1f77d745
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau
Autor:
Niklas Mattsson‐Carlgren, Shorena Janelidze, Randall J Bateman, Ruben Smith, Erik Stomrud, Geidy E Serrano, Eric M Reiman, Sebastian Palmqvist, Jeffrey L Dage, Thomas G Beach, Oskar Hansson
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 6, Pp 1-11 (2021)
Abstract Alzheimer’s disease is characterized by β‐amyloid plaques and tau tangles. Plasma levels of phospho‐tau217 (P‐tau217) accurately differentiate Alzheimer’s disease dementia from other dementias, but it is unclear to what degree thi
Externí odkaz:
https://doaj.org/article/aa5bbc2a0e2f418985e204cce77715cb
Autor:
Thomas G Beach, Charles H Adler, Nan Zhang, Geidy E Serrano, Lucia I Sue, Erika Driver-Dunckley, Shayamal H Mehta, Edouard E Zamrini, Marwan N Sabbagh, Holly A Shill, Christine M Belden, David R Shprecher, Richard J Caselli, Eric M Reiman, Kathryn J Davis, Kathy E Long, Lisa R Nicholson, Anthony J Intorcia, Michael J Glass, Jessica E Walker, Michael M Callan, Javon C Oliver, Richard Arce, Richard C Gerkin
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231720 (2020)
Many subjects with neuropathologically-confirmed dementia with Lewy bodies (DLB) are never diagnosed during life, instead being categorized as Alzheimer's disease dementia (ADD) or unspecified dementia. Unrecognized DLB therefore is a critical impedi
Externí odkaz:
https://doaj.org/article/185d07c965d94231a069e5f00e8cea58
Autor:
Michael Malek-Ahmadi, Thomas G Beach, Edward Zamrini, Charles H Adler, Marwan N Sabbagh, Holly A Shill, Sandra A Jacobson, Christine M Belden, Richard J Caselli, Brian K Woodruff, Steven Z Rapscak, Geoffrey L Ahern, Jiong Shi, John N Caviness, Erika Driver-Dunckley, Shyamal H Mehta, David R Shprecher, Bryan M Spann, Pierre Tariot, Kathryn J Davis, Kathy E Long, Lisa R Nicholson, Anthony Intorcia, Michael J Glass, Jessica E Walker, Michael Callan, Jasmine Curry, Brett Cutler, Javon Oliver, Richard Arce, Douglas G Walker, Lih-Fen Lue, Geidy E Serrano, Lucia I Sue, Kewei Chen, Eric M Reiman
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217566 (2019)
BackgroundNeuropathology has demonstrated a high rate of comorbid pathology in dementia due to Alzheimer's disease (ADD). The most common major comorbidity is Lewy body disease (LBD), either as dementia with Lewy bodies (AD-DLB) or Alzheimer's diseas
Externí odkaz:
https://doaj.org/article/20865cfb54d54fcb81882a55f80987e8
Autor:
Jing Qian, Frank J Wolters, Alexa Beiser, Mary Haan, M Arfan Ikram, Jason Karlawish, Jessica B Langbaum, John M Neuhaus, Eric M Reiman, J Scott Roberts, Sudha Seshadri, Pierre N Tariot, Beth McCarty Woods, Rebecca A Betensky, Deborah Blacker
Publikováno v:
PLoS Medicine, Vol 14, Iss 3, p e1002254 (2017)
BACKGROUND:With the onset of prevention trials for individuals at high risk for Alzheimer disease, there is increasing need for accurate risk prediction to inform study design and enrollment, but available risk estimates are limited. We developed ris
Externí odkaz:
https://doaj.org/article/b710f4a52ee946588e0dce05432650b4
Autor:
Yi Su, Tyler M Blazey, Christopher J Owen, Jon J Christensen, Karl Friedrichsen, Nelly Joseph-Mathurin, Qing Wang, Russ C Hornbeck, Beau M Ances, Abraham Z Snyder, Lisa A Cash, Robert A Koeppe, William E Klunk, Douglas Galasko, Adam M Brickman, Eric McDade, John M Ringman, Paul M Thompson, Andrew J Saykin, Bernardino Ghetti, Reisa A Sperling, Keith A Johnson, Stephen P Salloway, Peter R Schofield, Colin L Masters, Victor L Villemagne, Nick C Fox, Stefan Förster, Kewei Chen, Eric M Reiman, Chengjie Xiong, Daniel S Marcus, Michael W Weiner, John C Morris, Randall J Bateman, Tammie L S Benzinger, Dominantly Inherited Alzheimer Network
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152082 (2016)
Amyloid imaging plays an important role in the research and diagnosis of dementing disorders. Substantial variation in quantitative methods to measure brain amyloid burden exists in the field. The aim of this work is to investigate the impact of meth
Externí odkaz:
https://doaj.org/article/3c1e448b15fa468cb6de83c58a76a317
Autor:
Yi Su, Tyler M Blazey, Christopher J Owen, Jon J Christensen, Karl Friedrichsen, Nelly Joseph-Mathurin, Qing Wang, Russ C Hornbeck, Beau M Ances, Abraham Z Snyder, Lisa A Cash, Robert A Koeppe, William E Klunk, Douglas Galasko, Adam M Brickman, Eric McDade, John M Ringman, Paul M Thompson, Andrew J Saykin, Bernardino Ghetti, Reisa A Sperling, Keith A Johnson, Stephen P Salloway, Peter R Schofield, Colin L Masters, Victor L Villemagne, Nick C Fox, Stefan Förster, Kewei Chen, Eric M Reiman, Chengjie Xiong, Daniel S Marcus, Michael W Weiner, John C Morris, Randall J Bateman, Tammie L S Benzinger, Dominantly Inherited Alzheimer Network
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163669 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0152082.].
Externí odkaz:
https://doaj.org/article/34776afea7e04c56aaf53449f4d482fc
Autor:
Gary W Beecham, Kara Hamilton, Adam C Naj, Eden R Martin, Matt Huentelman, Amanda J Myers, Jason J Corneveaux, John Hardy, Jean-Paul Vonsattel, Steven G Younkin, David A Bennett, Philip L De Jager, Eric B Larson, Paul K Crane, M Ilyas Kamboh, Julia K Kofler, Deborah C Mash, Linda Duque, John R Gilbert, Harry Gwirtsman, Joseph D Buxbaum, Patricia Kramer, Dennis W Dickson, Lindsay A Farrer, Matthew P Frosch, Bernardino Ghetti, Jonathan L Haines, Bradley T Hyman, Walter A Kukull, Richard P Mayeux, Margaret A Pericak-Vance, Julie A Schneider, John Q Trojanowski, Eric M Reiman, Alzheimer's Disease Genetics Consortium (ADGC), Gerard D Schellenberg, Thomas J Montine
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004606 (2014)
Alzheimer's disease (AD) and related dementias are a major public health challenge and present a therapeutic imperative for which we need additional insight into molecular pathogenesis. We performed a genome-wide association study and analysis of kno
Externí odkaz:
https://doaj.org/article/16fab959c9274eda9e554f003340125a
Autor:
Chera L Maarouf, Tyler A Kokjohn, Douglas G Walker, Charisse M Whiteside, Walter M Kalback, Alexis Whetzel, Lucia I Sue, Geidy Serrano, Sandra A Jacobson, Marwan N Sabbagh, Eric M Reiman, Thomas G Beach, Alex E Roher
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105784 (2014)
Defining the biochemical alterations that occur in the brain during "normal" aging is an important part of understanding the pathophysiology of neurodegenerative diseases and of distinguishing pathological conditions from aging-associated changes. Th
Externí odkaz:
https://doaj.org/article/3f4835cd1a07417d822f3b2bc489143a
Autor:
Frank Schraml, Kewei Chen, Napatkamon Ayutyanont, Roontiva Auttawut, Jessica B S Langbaum, Wendy Lee, Xiaofen Liu, Dan Bandy, Stephanie Q Reeder, Gene E Alexander, Richard J Caselli, Adam S Fleisher, Eric M Reiman, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67163 (2013)
BACKGROUNDWe introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipopro
Externí odkaz:
https://doaj.org/article/700a91dbed794ea5b9db8ef982e21991