Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Eric M Gordon"'
Autor:
Nathanael S. Gray, Chaitan Khosla, Jinhua Wang, Christopher T. Walsh, Alexander M Soohoo, Thomas M Privalsky, Gerard D. Wright, Eric M. Gordon
Publikováno v:
J Am Chem Soc
The rising prevalence of multi-drug resistant bacteria is an urgent health crisis that can only be countered through renewed investment in the discovery and development of antibiotics. There is no panacea for the antibacterial resistance crisis; inst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3d1fc5d1fbae6492d5b036e3bd1ec6
https://doi.org/10.1021/jacs.1c10200
https://doi.org/10.1021/jacs.1c10200
Autor:
Jiawei Sun, Pingyu Ding, Duncton Matthew A J, Zhi-Jie Ni, Ruslan Grygorash, Guijun Yu, Longwu Qi, Brian J Wang, Xianfeng Li, Eric M. Gordon, Dazhong Fan, Eddy Low
Publikováno v:
ACS Med Chem Lett
[Image: see text] Aztreonam, first discovered in 1980, is an FDA approved, intravenous, monocyclic beta-lactam antibiotic. Aztreonam is active against Gram-negative bacteria and is still used today. The oral bioavailability of aztreonam in humans is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffbd7d2d5a5ccae1b375ffbf4fa6355
https://doi.org/10.1021/acsmedchemlett.9b00534
https://doi.org/10.1021/acsmedchemlett.9b00534
Publikováno v:
CHIMIA, Vol 51, Iss 11 (1997)
A strategic analysis of various issues which pertain to the enablement of combinatorial organic synthesis to produce libraries of non-polymeric organic molecules is given. Methods and examples of the development of solid-phase organic chemistry and i
Externí odkaz:
https://doaj.org/article/f001c357d58d49a0abc0c77e3fa6647f
Publikováno v:
Journal of medicinal chemistry. 61(22)
Only one FDA-approved β-lactamase inhibitor has ever been orally available: clavulanic acid, approved in 1984. Avibactam, approved by FDA in 2015, is the first of a new class of BLIs called diazabicyclooctanes, or “DBOs”. This class has much bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486f6b12c81d49c679e390ef5e953b6e
https://pubmed.ncbi.nlm.nih.gov/30296086
https://pubmed.ncbi.nlm.nih.gov/30296086
Autor:
Robert K. Naviaux, Eric M Gordon
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(6)
We thank Roerink et al. (1) for their comments. We respond to their two points in order. Their first point asked about the effect of physical activity on sphingolipids. The sphingolipid response to exercise is complex. It differs in healthy trained a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51151411731441dd2e00c362f8459511
https://pubmed.ncbi.nlm.nih.gov/28126718
https://pubmed.ncbi.nlm.nih.gov/28126718
Autor:
Wayne F. Anderson, Jane C. Naviaux, Eric M Gordon, Robert K. Naviaux, A. Taylor Bright, Neil Nathan, Kefeng Li, William A. Alaynick, Lin Wang, Asha Baxter
We thank Vogt et al. for their comments (1). We respond to their three points in order. First, we are aware of the need to extend future metabolomics studies to include other disease groups. We stated this fact in the discussion of ref. 2 and are val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e00e29743465dc704f5d13a5150100
https://europepmc.org/articles/PMC5135342/
https://europepmc.org/articles/PMC5135342/
Autor:
Jane C. Naviaux, Robert K. Naviaux, Kefeng Li, A. Taylor Bright, William A. Alaynick, Wayne F. Anderson, Asha Baxter, Eric M Gordon, Neil Nathan, Lin Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 37
More than 2 million people in the United States have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We performed targeted, broad-spectrum metabolomics to gain insights into the biology of CFS. We studied a total of 84 subjects using the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2526be45e4683235c5b89863679b0778
https://doi.org/10.1073/pnas.1607571113
https://doi.org/10.1073/pnas.1607571113
Autor:
David Campbell, James Schmeits, Shu-Hui Chen, Denise Hanway, David T. Winn, Wensheng Liao, Ruzhang Liu, Juan M. Betancort, Junjuan Liu, David P. Carney, Quansheng Xu, Xinqiang Li, Eric M. Gordon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4437-4440
The synthesis and biochemical evaluation of novel cyanothiazolidine inhibitors of dipeptidyl peptidase 4 (DPP4) is described. Their main structural feature is a constrained bicyclic core that prevents the intramolecular formation of inactive cyclic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02864d99059a1855e5292b3cc29ba38b
https://doi.org/10.1016/j.bmcl.2009.05.048
https://doi.org/10.1016/j.bmcl.2009.05.048
Autor:
Thomas O'Brien, Matthew T Burdett, Dennis Lee, Eric M Gordon, Warren L DeLano, Joni W. Lam, Phuongly Pham, Ingrid C. Choong, Willard Lew, Darin Allen, Bruce Fahr
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3651-3655
The design and synthesis of a series of novel, reversible, small molecule inhibitors of caspase-3 are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ef57df2ac796814a3ca81e3e0220b1
https://doi.org/10.1016/j.bmcl.2003.08.024
https://doi.org/10.1016/j.bmcl.2003.08.024
Autor:
Shaoqing Chen, Stuart Lam, Romeo Ciabatti, Joaquim Trias, Richard White, Gianpaolo Candiani, C J Hackbarth, Jeffrey W. Jacobs, Stefano Donadio, Eric M. Gordon, Jeffrey Clough, Gabriella Romano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3409-3414
Thiazole peptide GE2270 A (1) possesses potent antimicrobial activity against many gram-positive pathogens, including methicillin resistant Staphylococcus aureus (S. aureus, MRSA; MIC(90)=0.06 microg/mL) and vancomycin resistant Enterococcus spp. (VR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d111a58079a2ce745ca40d1ecac6d631
https://doi.org/10.1016/s0960-894x(03)00811-4
https://doi.org/10.1016/s0960-894x(03)00811-4