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pro vyhledávání: '"Eric M Chapman"'
Autor:
Eric M. Chapman, Benjamin Lant, Yota Ohashi, Bin Yu, Michael Schertzberg, Christopher Go, Deepika Dogra, Janne Koskimäki, Romuald Girard, Yan Li, Andrew G. Fraser, Issam A. Awad, Salim Abdelilah-Seyfried, Anne-Claude Gingras, W. Brent Derry
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cerebral Cavernous Malformations (CCM) are often caused by mutations in CCM1/KRIT1. Here, Chapman et al. elegantly show that the CCM complex promotes apoptosis by regulating zinc homeostasis and storage via a conserved mechanism that likely generates
Externí odkaz:
https://doaj.org/article/68d7cbe202d44ec59471ae5b3beec946
Autor:
Bin Yu, Matthew Eroglu, Thomas F. Duchaine, Samuel J Krempel, Mathieu N Flamand, Eric M Chapman, Anh Tran, W. Brent Derry
Publikováno v:
Cell Death and Differentiation
Apoptosis is a genetically programmed cell death process with profound roles in development and disease. MicroRNAs modulate the expression of many proteins and are often deregulated in human diseases, such as cancer. C. elegans germ cells undergo apo
Autor:
Issam A. Awad, Andrew G. Fraser, Bin Yu, Yota Ohashi, W. Brent Derry, Yan Li, Romuald Girard, Anne-Claude Gingras, Michael R Schertzberg, Salim Abdelilah-Seyfried, Deepika Dogra, Eric M Chapman, Christopher D. Go, Benjamin Lant, Janne Koskimäki
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unkn
Autor:
Julián Carrión-Penagos, Laleh Saadat, Janne Koskimäki, Romuald Girard, Issam A. Awad, Robert Shenkar, Amy Akers, Dongdong Zhang, Yan Li, Sharbel Romanos, Jorge Andrade, Hussein A. Zeineddine, Thomas R. Moore, Mark L. Kahn, Sean P. Polster, Gregory J. Fonseca, Alan T. Tang, Changbin Shi, Rhonda Lightle, Kenneth Avner, Evelyn Popiel, W. Brent Derry, Pieter W. Faber, Eric M Chapman, Seán B. Lyne, Mark H. Ginsberg, Douglas A. Marchuk, Ying Cao, Miguel Alejandro Lopez-Ramirez
Publikováno v:
JCI insight, vol 4, iss 3
The purpose of this study was to determine important genes, functions, and networks contributing to the pathobiology of cerebral cavernous malformation (CCM) from transcriptomic analyses across 3 species and 2 disease genotypes. Sequencing of RNA fro
Autor:
Eva Faurobert, Corinne Albiges-Rizo, W. Brent Derry, Swati Pal, Lisa Zhao, Daniel Witvliet, Soo Hyuk Choi, Benjamin Lant, Bin Yu, Eric M Chapman
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2018, 24 (11), pp.2857-2868.e4. ⟨10.1016/j.celrep.2018.08.039⟩
Cell Reports, Vol 24, Iss 11, Pp 2857-2868.e4 (2018)
Cell Reports, Elsevier Inc, 2018, 24 (11), pp.2857-2868.e4. ⟨10.1016/j.celrep.2018.08.039⟩
Cell Reports, Vol 24, Iss 11, Pp 2857-2868.e4 (2018)
Summary: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by mutations in one of three genes (CCM1–3). Loss of CCM3 causes the poorest prognosis, and little is known about how it regulates vascular integrity. The C. elegans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2e94e821a563e0529fe6cddc215b80
https://hal.archives-ouvertes.fr/hal-02354266/document
https://hal.archives-ouvertes.fr/hal-02354266/document
Publikováno v:
American journal of botany. 95(10)
Differences in the fl exibility of Pinus nigra and P. resinosa leaves can be used to discriminate these two similarly looking pine species from one another. When bent along the longitudinal axis, P. resinosa leaves snap, while P. nigra leaves appear