Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium

Autor: Satria P. Sajuthi, Peter DeFord, Yingchun Li, Nathan D. Jackson, Michael T. Montgomery, Jamie L. Everman, Cydney L. Rios, Elmar Pruesse, James D. Nolin, Elizabeth G. Plender, Michael E. Wechsler, Angel C. Y. Mak, Celeste Eng, Sandra Salazar, Vivian Medina, Eric M. Wohlford, Scott Huntsman, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Gonçalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Sam Oh, Jose Rodriguez-Santana, Esteban G. Burchard, Max A. Seibold

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)

ACE2 and TMPRSS2 have received recent attention as entry factors for SARS-CoV-2. Here the authors analyze nasal airway transcriptome data from 695 children determining ACE2 and TMPRSS2 expression is induced by viral and type2 inflammation, respective

Externí odkaz: https://doaj.org/article/5998991851af4757adcf82673111f6e4

Neurodevelopmental Delay Diagnosis Rates Are Increased in a Region with Aerial Pesticide Application

Autor: Steven D. Hicks, Ming Wang, Katherine Fry, Vignesh Doraiswamy, Eric M. Wohlford

Publikováno v: Frontiers in Pediatrics, Vol 5 (2017)

A number of studies have implicated pesticides in childhood developmental delay (DD) and autism spectrum disorder (ASD). The influence of the route of pesticide exposure on neurodevelopmental delay is not well defined. To study this factor, we examin

Externí odkaz: https://doaj.org/article/b3fa38566a16418f901458ab948425ca

The Optimization and Biological Significance of a 29-Host-Immune-mRNA Panel for the Diagnosis of Acute Infections and Sepsis

Autor: Ljubomir Buturovic, Oliver Liesenfeld, Eric M. Wohlford, Timothy E. Sweeney, Florian Uhle, Yudong D He

Publikováno v: Journal of Personalized Medicine
Volume 11
Issue 8
Journal of Personalized Medicine, Vol 11, Iss 735, p 735 (2021)

In response to the unmet need for timely accurate diagnosis and prognosis of acute infections and sepsis, host-immune-response-based tests are being developed to help clinicians make more informed decisions including prescribing antimicrobials, order

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6aa6d2d0fb09cd32f3e899011ad333c
https://pubmed.ncbi.nlm.nih.gov/34442377

Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium

Autor: Kenneth Rice, Elmar Pruesse, Satria Sajuthi, Hyun Min Kang, Michael E. Wechsler, Peter DeFord, Jamie L. Everman, Gonçalo R. Abecasis, Esteban G. Burchard, Michael C. Zody, Jose R. Rodriguez-Santana, A.C.Y. Mak, Sam S. Oh, James D. Nolin, Max A. Seibold, Vivian Medina, Eric M. Wohlford, Scott Huntsman, Sandra Salazar, Cydney Rios, Elizabeth G. Plender, M.T. Montgomery, Nathan D. Jackson, Deborah A. Nickerson, Soren Germer, Rajesh Kumar, Celeste Eng

Publikováno v: bioRxiv : the preprint server for biology, vol 1, iss 05-20
bioRxiv
article-version (status) pre
article-version (number) 1
Nature Communications

Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting the pattern and levels of expression of these genes is important for dee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f10f756f423e738e34f27358e1e333a
https://escholarship.org/uc/item/7vx3r7k0

Racial/ethnic differences in eligibility for asthma biologics among pediatric populations

Autor: Richardae Araojo, Celeste Eng, Esteban G. Burchard, Ronald L. Rabin, P.F. Huang, Jose R. Rodriguez-Santana, Jonathan Witonsky, Maria G. Contreras, Donglei Hu, Eric M. Wohlford, Christine Merenda, Jennifer R. Elhawary, Scott Huntsman, Cecile T.J. Holweg, Sam S. Oh, Michael A. LeNoir, Luisa N. Borrell, L. Millette, Angel C.Y. Mak, Christine M. Lee

Publikováno v: The Journal of allergy and clinical immunology, vol 148, iss 5
J Allergy Clin Immunol

BACKGROUND: Asthma is a heterogeneous disease. Clinical blood parameters differ by race/ethnicity and are used to distinguish asthma subtypes and inform therapies. Differences in subtypes may explain population-specific trends in asthma outcomes. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a762d6d636c1819d18017f281d780283
https://doi.org/10.1016/j.jaci.2021.09.005