Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Eric M, Shepard"'
Autor:
Hunter Fausset, Rachel L. Spietz, Savannah Cox, Gwendolyn Cooper, Scott Spurzem, Monika Tokmina-Lukaszewska, Jennifer DuBois, Joan B. Broderick, Eric M. Shepard, Eric S. Boyd, Brian Bothner
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTIron (Fe) and sulfur (S) are required elements for life, and changes in their availability can limit the ecological distribution and function of microorganisms. In anoxic environments, soluble Fe typically exists as ferrous iron [Fe(II)] and
Externí odkaz:
https://doaj.org/article/b3728bd804bb451e879f643c3aba1322
Publikováno v:
Angewandte Chemie (International ed. in English). 61(49)
The [FeFe]-hydrogenase H-cluster is a complex organometallic cofactor whose assembly and installation requires three dedicated accessory proteins referred to as HydE, HydF, and HydG. The roles of these maturases and the precise mechanisms by which th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ba4d9c1bf7174cab04c2be23be4202
https://pubmed.ncbi.nlm.nih.gov/36137942
https://pubmed.ncbi.nlm.nih.gov/36137942
Autor:
Katherine F. Steward, Devon Payne, Will Kincannon, Christina Johnson, Malachi Lensing, Hunter Fausset, Brigitta Németh, Eric M. Shepard, William E. Broderick, Joan B. Broderick, Jen Dubois, Brian Bothner
Publikováno v:
Microbiology spectrum. 10(4)
Iron sulfur (Fe-S) proteins are essential and ubiquitous across all domains of life, yet the mechanisms underpinning assimilation of iron (Fe) and sulfur (S) and biogenesis of Fe-S clusters are poorly understood. This is particularly true for anaerob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c891d841d5318c4fe8b3eb58d749c5
https://pubmed.ncbi.nlm.nih.gov/35876569
https://pubmed.ncbi.nlm.nih.gov/35876569
Autor:
Stella Impano, Hao Yang, Eric M. Shepard, Ryan Swimley, Adrien Pagnier, William E. Broderick, Brian M. Hoffman, Joan B. Broderick
Publikováno v:
Angew Chem Int Ed Engl
Radical S-adenosyl-l-methionine (SAM) enzymes initiate biological radical reactions with the 5’-deoxyadenosyl radical (5’-dAdo•). A [4Fe-4S](+) cluster reductively cleaves SAM to form the Ω organometallic intermediate in which the 5’-deoxyad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd0170a76ecd0e1b189c51a7643cec4
https://doi.org/10.1002/anie.202014337
https://doi.org/10.1002/anie.202014337
Autor:
Elizabeth C. McDaniel, Jeremiah N. Betz, William E. Broderick, Joan B. Broderick, Adrien Pagnier, Eric M. Shepard, John W. Peters, Amanda S. Byer, Stella Impano, Amanda Galambas, Hope Watts, Kaitlin S. Duschene, Benjamin R. Duffus, Shawn E. McGlynn
Publikováno v:
Dalton Transactions. 50:10405-10422
The organometallic H-cluster of the [FeFe]-hydrogenase consists of a [4Fe-4S] cubane bridged via a cysteinyl thiolate to a 2Fe subcluster ([2Fe]H) containing CO, CN-, and dithiomethylamine (DTMA) ligands. The H-cluster is synthesized by three dedicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3bcff9b8c51cdf25076b11b64769e81
https://doi.org/10.1039/d1dt01359a
https://doi.org/10.1039/d1dt01359a
Autor:
Adrien Pagnier, Batuhan Balci, Eric M. Shepard, Hao Yang, Douglas M. Warui, Stella Impano, Squire J. Booker, Brian M. Hoffman, William E. Broderick, Joan B. Broderick
Publikováno v:
Angew Chem Int Ed Engl
Maturation of [FeFe]-hydrogenase (HydA) involves synthesis of a CO, CN(−), and dithiomethylamine (DTMA)-coordinated 2Fe subcluster that is inserted into HydA to make the active hydrogenase. This process requires three maturation enzymes: the radica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09661f5a4c7ab764336759118505ab9
https://doi.org/10.1002/anie.202203413
https://doi.org/10.1002/anie.202203413
Autor:
Adrien Pagnier, Batuhan Balci, Eric M. Shepard, Hao Yang, Douglas M. Warui, Stella Impano, Squire J. Booker, Brian M. Hoffman, William E. Broderick, Joan B. Broderick
Publikováno v:
Angewandte Chemie. 134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a257bffe4af9df7d3f04699f945b62
https://doi.org/10.1002/ange.202204929
https://doi.org/10.1002/ange.202204929
Autor:
Adrien Pagnier, Batuhan Balci, Eric M. Shepard, Hao Yang, Douglas M. Warui, Stella Impano, Squire J. Booker, Brian M. Hoffman, William E. Broderick, Joan B. Broderick
Publikováno v:
Angewandte Chemie International Edition. 61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::658a3593eca530cc772d263a140d3f64
https://doi.org/10.1002/anie.202204929
https://doi.org/10.1002/anie.202204929
Autor:
Eric M. Shepard, Hao Yang, Ryan Swimley, William E. Broderick, Joan B. Broderick, Richard J. Jodts, Stella Impano, Elizabeth C. McDaniel, Adrien Pagnier, Brian M. Hoffman
Publikováno v:
Journal of the American Chemical Society. 143:335-348
Catalysis by canonical radical S-adenosyl-l-methionine (SAM) enzymes involves electron transfer (ET) from [4Fe-4S]+ to SAM, generating an R3S0 radical that undergoes regioselective homolytic reductive cleavage of the S-C5' bond to generate the 5'-dAd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::149114bf161e3b473c60d0eaddb91931
https://doi.org/10.1021/jacs.0c10925
https://doi.org/10.1021/jacs.0c10925
Autor:
Katherine F. Steward, Sue Brumfield, Eric M. Shepard, Brian Bothner, Eric S. Boyd, Devon Payne, William E. Broderick, Mark J. Young, Joan B. Broderick, Rachel L. Spietz
Publikováno v:
Journal of Bacteriology
Methanogens have a high demand for iron (Fe) and sulfur (S); however, little is known of how they acquire, deploy, and store these elements and how this, in turn, affects their physiology. Methanogens were recently shown to reduce pyrite (FeS2), gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d23579010ec97ab902af548a231881
https://pubmed.ncbi.nlm.nih.gov/34251867
https://pubmed.ncbi.nlm.nih.gov/34251867