Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Eric M, Morrow"'
Publikováno v:
Biology Open, Vol 12, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/44b3ccecd30a4546bf07a5ef9a3d4110
Autor:
Emily B. Warren, Juan A. Briano, Jacob Ellegood, Taylor DeYoung, Jason P. Lerch, Eric M. Morrow
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 12 (2022)
Externí odkaz:
https://doaj.org/article/8ac7e09c51ff4e20b8b3443aa8fab639
Publikováno v:
Neurobiology of Disease, Vol 173, Iss , Pp 105831- (2022)
Locus coeruleus (LC) is among the first brain areas to degenerate in Alzheimer's disease and Parkinson's disease; however, the underlying causes for the vulnerability of LC neurons are not well defined. Here we report a novel mechanism of degeneratio
Externí odkaz:
https://doaj.org/article/6431a3c8aa0a422f8c7d58e17ed741f8
Publikováno v:
Stem Cell Research, Vol 54, Iss , Pp 102435- (2021)
Loss-of-function mutations in Na+/H + exchanger 6 (NHE6) (also termed SLC9A6) cause the X-linked neurogenetic disorder Christianson syndrome (CS). Using peripheral blood mononuclear cells, we developed induced pluripotent stem cell (iPSC) lines from
Externí odkaz:
https://doaj.org/article/2698b63b38c34c9a9475a54e6a7db723
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102323- (2021)
Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is an autosomal recessive neurodegenerative disorder generally with onset at 2 to 4 years of age and characterized by seizures, loss of vision, progressive motor and mental decline, and premature d
Externí odkaz:
https://doaj.org/article/ed454a3b6667474e95659c1fc1c41871
Autor:
Matthew Schwede, Shailender Nagpal, Michael J. Gandal, Neelroop N. Parikshak, Karoly Mirnics, Daniel H. Geschwind, Eric M. Morrow
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Background Genetic studies in autism have pinpointed a heterogeneous group of loci and genes. Further, environment may be an additional factor conferring susceptibility to autism. Transcriptome studies investigate quantitative differences in
Externí odkaz:
https://doaj.org/article/a43d93e689e243578493a25a6b22a5a9
Autor:
Kristen J. Brennand, M. Carol Marchetto, Nissim Benvenisty, Oliver Brüstle, Allison Ebert, Juan Carlos Izpisua Belmonte, Ajamete Kaykas, Madeline A. Lancaster, Frederick J. Livesey, Michael J. McConnell, Ronald D. McKay, Eric M. Morrow, Alysson R. Muotri, David M. Panchision, Lee L. Rubin, Akira Sawa, Frank Soldner, Hongjun Song, Lorenz Studer, Sally Temple, Flora M. Vaccarino, Jun Wu, Pierre Vanderhaeghen, Fred H. Gage, Rudolf Jaenisch
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 933-945 (2015)
As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism
Externí odkaz:
https://doaj.org/article/2296612bb377433592323ebb3a16fbea
Autor:
YouJin Lee, Morgan R Miller, Marty A Fernandez, Elizabeth L Berg, Adriana M Prada, Qing Ouyang, Michael Schmidt, Jill L Silverman, Tracy L Young-Pearse, Eric M Morrow
Publikováno v:
Brain
Brain : a journal of neurology, vol 145, iss 9
Brain : a journal of neurology, vol 145, iss 9
Loss-of-function mutations in the X-linked endosomal Na+/H+ exchanger 6 (NHE6) cause Christianson syndrome in males. Christianson syndrome involves endosome dysfunction leading to early cerebellar degeneration, as well as later-onset cortical and sub
Publikováno v:
Autism Research. 15:86-92
Advanced parental age at offspring birth has been associated with autism spectrum disorder (ASD). The objective of the current study was to investigate associations between parental age at birth and autism severity. The Rhode Island Consortium for Au
Publikováno v:
The Journal of Neuroscience
Loss-of-function mutations in endosomal Na+/H+exchanger 6 (NHE6) cause the X-linked neurologic disorder Christianson syndrome. Patients exhibit symptoms associated with both neurodevelopmental and neurodegenerative abnormalities. While loss of NHE6 h