Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Eric M, Lewandowski"'
Autor:
Yanmei Hu, Eric M. Lewandowski, Haozhou Tan, Xiaoming Zhang, Ryan T. Morgan, Xiujun Zhang, Lian M. C. Jacobs, Shane G. Butler, Maura V. Gongora, John Choy, Xufang Deng, Yu Chen, Jun Wang
Publikováno v:
ACS Central Science, Vol 9, Iss 8, Pp 1658-1669 (2023)
Externí odkaz:
https://doaj.org/article/05a36a36b769471388ffab230a57b808
Autor:
Jin Ou, Eric M Lewandowski, Yanmei Hu, Austin A Lipinski, Ali Aljasser, Mariliz Colon-Ascanio, Ryan T Morgan, Lian M C Jacobs, Xiujun Zhang, Melissa J Bikowitz, Paul R Langlais, Haozhou Tan, Jun Wang, Yu Chen, John S Choy
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011592 (2023)
The SARS-CoV-2 main protease (Mpro) is a major therapeutic target. The Mpro inhibitor, nirmatrelvir, is the antiviral component of Paxlovid, an orally available treatment for COVID-19. As Mpro inhibitor use increases, drug resistant mutations will li
Externí odkaz:
https://doaj.org/article/39ca587144e144418e7e1eb6c544ee20
Autor:
Michael D. Sacco, Shaohui Wang, Swamy R. Adapa, Xiujun Zhang, Eric M. Lewandowski, Maura V. Gongora, Dimitra Keramisanou, Zachary D. Atlas, Julia A. Townsend, Jean R. Gatdula, Ryan T. Morgan, Lauren R. Hammond, Michael T. Marty, Jun Wang, Prahathees J. Eswara, Ioannis Gelis, Rays H. Y. Jiang, Xingmin Sun, Yu Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Antibiotics of the β-lactam class inhibit bacterial cell wall synthesis by targeting penicillin-binding proteins (PBPs). Here, Sacco et al. study the four PBPs present in the pathogen C. difficile, revealing unique structural features and shedding l
Externí odkaz:
https://doaj.org/article/ab479e50342c4a208865cf0e9e27f5cd
Autor:
Daniel R. Dempsey, Derek A. Nichols, Matthew R. Battistini, Orville Pemberton, Santiago Rodriguez Ospina, Xiujun Zhang, Anne-Marie Carpenter, Brian G. O’Flynn, James W. Leahy, Ankush Kanwar, Eric M. Lewandowski, Yu Chen, David J. Merkler
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Agmatine N-acetyltransferase (AgmNAT) catalyzes the formation of N-acetylagmatine from acetyl-CoA and agmatine. Herein, we provide evidence that Drosophila melanogaster AgmNAT (CG15766) catalyzes the formation of N-acetylagmatine using an or
Externí odkaz:
https://doaj.org/article/b2083b0e3aaf4cd49387f1ef030550cb
Autor:
Yanmei Hu, Eric M. Lewandowski, Haozhou Tan, Xiaoming Zhang, Ryan T. Morgan, Xiujun Zhang, Lian M. C. Jacobs, Shane G. Butler, Maura V. Gongora, John Choy, Xufang Deng, Yu Chen, Jun Wang
Publikováno v:
bioRxiv : the preprint server for biology.
The SARS-CoV-2 main protease (Mpro) is the drug target of Pfizer’s oral drug Paxlovid. The emergence of SARS-CoV-2 variants with mutations in Mpro raised the alarm of potential drug resistance. In this study, we identified 100 naturally occurring M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8be467d61742063e805ad24ebad2726
https://pubmed.ncbi.nlm.nih.gov/36119652
https://pubmed.ncbi.nlm.nih.gov/36119652
Autor:
Jin Ou, Eric M. Lewandowski, Yanmei Hu, Austin A. Lipinski, Ryan T. Morgan, Lian M.C. Jacobs, Xiujun Zhang, Melissa J. Bikowitz, Paul Langlais, Haozhou Tan, Jun Wang, Yu Chen, John S. Choy
Publikováno v:
bioRxiv
The SARS-CoV-2 main protease (Mpro) is a major therapeutic target. The Mpro inhibitor, nirmatrelvir, is the antiviral component of Paxlovid, an orally available treatment for COVID-19. As Mpro inhibitor use increases, drug resistant mutations will li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f7ee0ec99dd96aecdc82a3a6f3de26
https://europepmc.org/articles/PMC9387140/
https://europepmc.org/articles/PMC9387140/
Autor:
Gabriela Suarez, Eric M. Lewandowski, Yu Chen, David J. Merkler, Nasha M Rios-Guzman, Karin Claire Prins, Ioannis Gelis, Britney A. Shepherd, James W. Leahy, Ryan L. Anderson, Angelica N McCaskey, Brian G. O'Flynn
Publikováno v:
ACS Chemical Biology. 15:513-523
The growing issue of insecticide resistance has meant the identification of novel insecticide targets has never been more important. Arylalkylamine N-acyltransferases (AANATs) have been suggested as a potential new target. These promiscuous enzymes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3791a5745132aba9dd63b58601dc2eec
https://doi.org/10.1021/acschembio.9b00973
https://doi.org/10.1021/acschembio.9b00973
Autor:
Eric M. Lewandowski, Kyle G. Kroeck, Lian M.C. Jacobs, Tyler G. Fenske, Robin N. Witt, Alyssa M. Hintz, Elizabeth R. Ramsden, Xiujun Zhang, Francis Peterson, Brian F. Volkman, Christopher T. Veldkamp, Yu Chen
Publikováno v:
Biochemistry
The human chemokines CCL19 and CCL21 bind to the G-protein coupled receptor (GPCR) CCR7 and play an important role in the trafficking of immune cells, as well as cancer metastasis. Conserved binding sites for sulfotyrosine residues on the receptor co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f708794d43a7b1b708cbed603e4d6421
https://europepmc.org/articles/PMC9254573/
https://europepmc.org/articles/PMC9254573/
Autor:
Michael D. Sacco, Shaohui Wang, Swamy R. Adapa, Xiujun Zhang, Maura V. Gongora, Jean R. Gatdula, Eric M. Lewandowski, Lauren R. Hammond, Julia A. Townsend, Michael T. Marty, Jun Wang, Prahathees J. Eswara, Rays H.Y. Jiang, Xingmin Sun, Yu Chen
β-Lactam antibiotics, particularly cephalosporins, are major risk factors for C. difficile infection (CDI), the most common hospital acquired infection. These broad-spectrum antibiotics irreversibly inhibit penicillin-binding proteins (PBPs), essent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b0c6309f718d038b740daa4285471e9
https://doi.org/10.1101/2022.01.04.474981
https://doi.org/10.1101/2022.01.04.474981
Autor:
Nane C Kuznik, Simone Gräßle, Andrew C.B. Cato, Qing Lei, Nicole Jung, Amina Zoubeidi, Eric M. Lewandowski, Valeria Solozobova, Ravi Shashi Nayana Munuganti, Stefan Bräse, Yu Chen
Publikováno v:
ACS chemical biology. 16(11)
All current clinically approved androgen deprivation therapies for prostate cancer target the C-terminal ligand-binding domain of the androgen receptor (AR). However, the main transactivation function of the receptor is localized at the AR N-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d8a7ed2a77a8c7d22874296fa12fcb
https://pubmed.ncbi.nlm.nih.gov/34506104
https://pubmed.ncbi.nlm.nih.gov/34506104