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Increased bioavailability of celecoxib under fed versus fasted conditions is determined by postprandial bile secretion as demonstrated in a dynamic gastrointestinal model

Autor: Prathap Nagaraja Shastri, John Sagartz, Eric Lyng, Robert Havenaar, Lucy Hetsco, Andrew Vick

Publikováno v: Drug Development and Industrial Pharmacy. 42:1334-1339

The objective of this study was to utilize physiologically relevant dynamic dissolution testing with the TNO intestinal model (TIM-1) in vitro gastrointestinal model to investigate the bioaccessibility of celecoxib. A single 200-mg dose of celecoxib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4316624d49e3c014eb4e03e8545ea8
https://doi.org/10.3109/03639045.2015.1135935

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IL-1R Signaling within the Central Nervous System Regulates CXCL12 Expression at the Blood-Brain Barrier and Disease Severity during Experimental Autoimmune Encephalomyelitis

Autor: Eric Lyng, Robyn S. Klein, Matthew D. Budde, Jason R. Lees, Denise A. Dorsey, Erin E. McCandless

Publikováno v: The Journal of Immunology. 183:613-620

Multiple sclerosis (MS) is an autoimmune disease of the CNS characterized by disruption of the blood-brain barrier (BBB). This breach in CNS immune privilege allows undeterred trafficking of myelin-specific lymphocytes into the CNS where they induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbe879eba15b0b11136326ffb453fa4
https://doi.org/10.4049/jimmunol.0802258

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