Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eric Lorent"'
Autor:
Johan Desmet, Yvonne McGrath, Sophie Thiolloy, Eric Lorent, Pieter Van Vlierberghe, Stefan Loverix, Karen Vandenbroucke, Savvas N. Savvides, Lisa Demoen, Franky Baatz, Sabrina Deroo, Maaike Van Trimpont, Philippe Alard, Paula Henderikx, Ignace Lasters, Klaartje Somers, Tim Pieters, Erwin Pannecoucke, Lindy Reunes, Marnik Vuylsteke
Publikováno v:
'Science Advances ', vol: 7, pages: eabe1682-1-eabe1682-17 (2021)
Science Advances
Science advances 7(13), eabe1682 (2021). doi:10.1126/sciadv.abe1682
SCIENCE ADVANCES
Science Advances
Science advances 7(13), eabe1682 (2021). doi:10.1126/sciadv.abe1682
SCIENCE ADVANCES
Science advances 7(13), eabe1682 (2021). doi:10.1126/sciadv.abe1682
The therapeutic scope of antibody and nonantibody protein scaffolds is still prohibitively limited against intracellular drug targets. Here, we demonstrate that the Alphabody sc
The therapeutic scope of antibody and nonantibody protein scaffolds is still prohibitively limited against intracellular drug targets. Here, we demonstrate that the Alphabody sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f1a64aa5091424a4696ff8b839c4dc
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57573
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57573
Autor:
P. Henderikx, Stefan Loverix, S. Thiolloy, S. Deroo, Yvonne McGrath, F. Baatz, Karen Vandenbroucke, J. Desmet, P. Alard, I. Lemmens, Eric Lorent, I. Lasters
Publikováno v:
European Journal of Cancer. 69:S132-S133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a107fb7ad7e1e46209ec9effb0b3218
https://doi.org/10.1016/s0959-8049(16)32993-8
https://doi.org/10.1016/s0959-8049(16)32993-8
Publikováno v:
Vaccine. 26:399-410
The structure of the ectodomain of the hepatitis C envelope glycoprotein E1 (E1s) was characterised by spectroscopic methods. Monomeric E1s was purified from a mammalian and from a Hansenula polymorpha cell lysate, and cysteine-blocked monomers were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac3054f5a370bd74944312e55651cc6
https://doi.org/10.1016/j.vaccine.2007.11.004
https://doi.org/10.1016/j.vaccine.2007.11.004
Autor:
Franky Baatz, Stefan Loverix, Yvonne McGrath, Ignace Lasters, Karen Vandenbroucke, Sophie Thiolloy, Sabrina Deroo, Philippe Alard, Paula Henderikx, Johan Desmet, Eric Lorent
Publikováno v:
Cancer Research. 77:28-28
The pro-survival protein Myeloid Cell Leukaemia-1 (Mcl-1) plays an essential role in survival of numerous cancers. MCL-1 gene amplifications occur in a variety of human cancers and overexpression of the Mcl-1 protein is often associated with chemothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47e5f588edac7113d067ba2bb10c042
https://doi.org/10.1158/1538-7445.am2017-28
https://doi.org/10.1158/1538-7445.am2017-28
Autor:
Karen Vandenbroucke, Savvas N. Savvides, Bart Devreese, Klaartje Somers, Johan Desmet, Yurong Wen, Yehudi Bloch, Paula Henderikx, Thore Hettmann, Stefan Loverix, Kenneth Verstraete, Ignace Lasters, Eric Lorent, Sabrina Deroo
Publikováno v:
Nature Communications
'Nature Communications ', vol: 5, pages: 5237-1-5237-12 (2014)
NATURE COMMUNICATIONS
Nature Communications 5, 5237 (20142014). doi:10.1038/ncomms6237
'Nature Communications ', vol: 5, pages: 5237-1-5237-12 (2014)
NATURE COMMUNICATIONS
Nature Communications 5, 5237 (20142014). doi:10.1038/ncomms6237
Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics. Here we describe the design and development of the Alphabody, a protein scaffold featuring a single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bbd28c421cfa393d6aaf8adf6d7087
http://europepmc.org/articles/PMC4220489
http://europepmc.org/articles/PMC4220489
Autor:
Philippe Alard, Paula Henderikx, Karen Vandenbroucke, Ignace Lasters, Irma Lemmens, Franky Baatz, Johan Desmet, Sabrina Deroo, Eric Lorent, Stefan Loverix, Yvonne McGrath, Sophie Thiolloy
Publikováno v:
Cancer Research. 76:3850-3850
We have developed Cell Penetrating Alphabodies (CPABs), a novel and unique therapeutic class of proteins engineered to efficiently enter cells. In vitro, uptake in a range of tumor and non-tumor cell types occurs rapidly with cytosol levels of up to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b941e9c3a83449d94d0370e4f789d7
https://doi.org/10.1158/1538-7445.am2016-3850
https://doi.org/10.1158/1538-7445.am2016-3850
Autor:
Layla Gould, Marla J.S. Mickleborough, Adam Wu, Jose Tellez, Chelsea Ekstrand, Eric Lorentz, Tasha Ellchuk, Paul Babyn, Ron Borowsky
Publikováno v:
Epilepsy and Behavior Case Reports, Vol 5, Iss C, Pp 6-10 (2016)
We report a 55-year-old, right-handed patient with intractable left temporal lobe epilepsy, who previously had a partial left temporal lobectomy. The patient could talk during seizures, suggesting that he might have language dominance in the right he
Externí odkaz:
https://doaj.org/article/6530feef2adb440e89b42a05f22091ab