Efficacy and Safety of Cenicriviroc in Patients With Primary Sclerosing Cholangitis: PERSEUS Study

Autor: Bertus Eksteen, Christopher L. Bowlus, Aldo J. Montano‐Loza, Eric Lefebvre, Laurent Fischer, Pamela Vig, Eduardo Bruno Martins, Jawad Ahmad, Kidist K. Yimam, Paul J. Pockros, Jordan J. Feld, Gerald Minuk, Cynthia Levy

Publikováno v: Hepatology Communications, Vol 5, Iss 3, Pp 478-490 (2021)

Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease with no approved treatments. C‐C chemokine receptor types 2 and 5 (CCR2/CCR5) play an important role in inflammation and fibrosis and are potential therapeutic targets for PSC. W

Externí odkaz: https://doaj.org/article/445b1506b3f24ee187d83f0479859b6e

APOBEC3G/3A Expression in Human Immunodeficiency Virus Type 1-Infected Individuals Following Initiation of Antiretroviral Therapy Containing Cenicriviroc or Efavirenz

Autor: Daniela A. Covino, Cristina Purificato, Laura Catapano, Clementina M. Galluzzo, Maria Cristina Gauzzi, Stefano Vella, Eric Lefebvre, Star Seyedkazemi, Mauro Andreotti, Laura Fantuzzi

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) family members are cytidine deaminases that play crucial roles in innate responses to retrovirus infection. The mechanisms by which some of these enzymes restrict human immun

Externí odkaz: https://doaj.org/article/1ac93d00312f4001bdce8484eede90de

Differential impact of the dual CCR2/CCR5 inhibitor cenicriviroc on migration of monocyte and lymphocyte subsets in acute liver injury.

Autor: Tobias Puengel, Oliver Krenkel, Marlene Kohlhepp, Eric Lefebvre, Tom Luedde, Christian Trautwein, Frank Tacke

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184694 (2017)

A hallmark of acute hepatic injury is the recruitment of neutrophils, monocytes and lymphocytes, including natural killer (NK) or T cells, towards areas of inflammation. The recruitment of leukocytes from their reservoirs bone marrow or spleen into t

Externí odkaz: https://doaj.org/article/77654ab367614102adde95dc4dec9e9b

Cenicriviroc, a Novel CCR5 (R5) and CCR2 Antagonist, Shows In Vitro Activity against R5 Tropic HIV-2 Clinical Isolates.

Autor: Benoit Visseaux, Charlotte Charpentier, Gilles Collin, Mélanie Bertine, Gilles Peytavin, Florence Damond, Sophie Matheron, Eric Lefebvre, Françoise Brun-Vézinet, Diane Descamps, ANRS CO5 HIV-2 Cohort

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134904 (2015)

Maraviroc activity against HIV-2, a virus naturally resistant to different HIV-1 antiretroviral drugs, has been recently demonstrated. The aim of this study was to assess HIV-2 susceptibility to cenicriviroc, a novel, once-daily, dual CCR5 and CCR2 a

Externí odkaz: https://doaj.org/article/c0a5889cbd164ac6b410fe27602c63ff

The SUBGLACIOR drilling probe: hydraulic considerations

Autor: Jack Triest, Jérôme Chappellaz, Luc Piard, R. Duphil, Pavel Talalay, Philippe Possenti, Olivier Alemany, P. Boissonneau, J. F. Chemin, Eric Lefebvre

Publikováno v: Annals of Glaciology
Annals of Glaciology, International Glaciological Society, 2021, 62 (84), pp.131-142. ⟨10.1017/aog.2020.79⟩
Annals of Glaciology, 2021, 62 (84), pp.131-142. ⟨10.1017/aog.2020.79⟩

Using significant technological breakthroughs and unconventional approaches, the goal of the in situ probing of glacier ice for a better understanding of the orbital response of climate (SUBGLACIOR) project is to advance ice core research by inventin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c63ee241b57f00d7b2820a8b6bce87
https://doi.org/10.1017/aog.2020.79