Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Eric Labonte"'
Autor:
Jill Kohler, Susanne Johansson, David P. Rosenbaum, Andrew Spencer, Maria Leonsson-Zachrisson, Kenji Kozuka, Dominique Charmot, Eric Labonte, Desiree Deshpande, Mikael Knutsson
Publikováno v:
Clinical Pharmacology in Drug Development. 6:448-456
Tenapanor (RDX5791, AZD1722), a first-in-class small molecule with minimal systemic availability, is an inhibitor of the sodium/hydrogen exchanger isoform 3. Tenapanor acts locally in the gut, where it reduces absorption of sodium and phosphate. It i
Autor:
Matthias H. Tschöp, Juan C. Roja, Daniel P. Magness, Paul T. Pfluger, Eric Labonte, David G. Kuhel, James G. Cash, Ronald J. Jandacek, David Y. Hui
Publikováno v:
The FASEB Journal. 24:2516-2524
Decrease in fat catabolic rate on consuming a high-fat diet contributes to diet-induced obesity. This study used group 1B phospholipase A2 (Pla2g1b)-deficient mice, which are resistant to hyperglycemia, to test the hypothesis that Pla2g1b and its lip
Autor:
Dean Gilham, David Y. Hui, Ronald J. Jandacek, Lisa M. Camarota, Joanna P. Davies, Patrick Tso, Eric Labonte, Philip N. Howles, Yiannis A. Ioannou, Juan C. Rojas
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 295:G776-G783
The impact of NPC1L1 and ezetimibe on cholesterol absorption are well documented. However, their potential consequences relative to absorption and metabolism of other nutrients have been only minimally investigated. Thus studies were undertaken to in
Autor:
Eric Labonte, Roselle E. Crombie, Shaher Kahn, John Palmer, Jacqueline Laird, Phillip Fidler, Nabil A. Atweh, Paul Possenti, John T. Schulz, Sally Dalton, Edward C. Kaine, Andrea Warren
Publikováno v:
Journal of Burn Care & Research. 29:204-207
The expectation of excellent functional and cosmetic outcomes adds to the challenges of managing the burned hand. The initial fragility of the grafted surface warrants extra measures of protection. A "roll-bar " attached to a splint over a grafted ar
Autor:
Eric Labonte, Lori E. Macdonald, Jennifer Guenther, J. Xavier Lucio, David Lorello, Catherine Knox, Bernadette Nedelec, Sara Bills, Joanne Cheal, Jennifer Kemp-Offenberg, Kara Pontius, Lynne Benavides, Sarah Duch, Hernish Acharya, Donna Crump, Lorie A. Kloda, Annick Chouinard, Candice L. Osborne, Matthew Godleski, Ana de Oliveira, Ingrid Parry, Janelle L. Bucher, Miranda L Yelvington
Publikováno v:
Journal of burn careresearch : official publication of the American Burn Association. 37(6)
The objective of this review was to systematically evaluate the available clinical evidence for the prescription of strength training and cardiovascular endurance exercise programs for pediatric and adult burn survivors so that practice guidelines co
Autor:
Jill Kohler, Desiree Deshpande, Ziyang Zhong, Michael R. Leadbetter, Ingrid Langsetmo, Marc Navre, Christopher Carreras, Andrew Spencer, Kenji Kozuka, Jason G. Lewis, Edward Dy, Eric Labonte, Deborah Black, Limin He, Jeffrey W. Jacobs, Noah Bell, Dominique Charmot, Samantha Koo-McCoy
Publikováno v:
Journal of the American Society of Nephrology : JASN. 26(5)
In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic cascade leading to hyperthyroidism, metabolic bone disease, vascular calcification, and cardiovascular mortality. Tenapanor, a minimally systemically availabl
Autor:
Noah Bell, Kenji Kozuka, Jeffrey W. Jacobs, David P. Rosenbaum, Kristin M. Joly, Marc Navre, Limin He, Jocelyn Tabora, Christopher Carreras, Dominique Charmot, Samantha Koo-McCoy, Andrew Spencer, Eric Labonte, Michael R. Leadbetter, Jill Kohler, Craig F. Plato
Publikováno v:
Science Translational Medicine. 6
The management of sodium intake is clinically important in many disease states including heart failure, kidney disease, and hypertension. Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodi
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 294(4)
Intestinal cholesterol absorption is modulated by transport proteins in enterocytes. Cholesterol uptake from intestinal lumen requires several proteins on apical brush-border membranes, including Niemann-Pick C1-like 1 (NPC1L1), scavenger receptor B-
Autor:
Eric Labonte, David Y. Hui, Kevin W. Huggins, April M. Cannon, R. Jason Kirby, Nicholas M. Schildmeyer
Publikováno v:
Diabetes. 55(4)
Postprandial hyperglycemia is an early indicator of abnormality in glucose metabolism leading to type 2 diabetes. However, mechanisms that contribute to postprandial hyperglycemia have not been identified. This study showed that mice with targeted in