Výsledky vyhledávání - "Eric L. Stangeland"

A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: Synthesis and structure–activity relationships

Autor: William J. Martin, Priscilla Van Dyke, Jacqueline A.M. Smith, D. Roland Saito, Eric L. Stangeland, Lori Jean Van Orden, Timothy J. Church, Sarah Jaw-Tsai, R. S. L. Chang

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:1456-1461

A series of 3-(phenoxy-phenyl-methyl)-pyrrolidine analogues were discovered to be potent and balanced norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors. Several of these compounds were identified to have suitable in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c607e388726740efdcbd3afb2529d4e
https://doi.org/10.1016/j.bmcl.2012.12.061

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Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation

Autor: Noach de Haas, Eric L. Stangeland, Tod Steinfeld, Mathai Mammen, Lambertus P. W. Witte, Martin C. Michel, Jayashree Aiyar

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology; Vol 384
Naunyn-Schmiedeberg's Archives of Pharmacology
Naunyn-Schmiedeberg s archives of pharmacology, 384(6), 555-563. Springer Verlag

β-Adrenoceptors are important mediators of smooth muscle relaxation in the urinary bladder, but the concomitant presence of a muscarinic agonist, e.g., carbachol, can attenuate relaxation responses by reducing potency and/or efficacy of β-adrenocep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6cc4ecdb8f30bcf4df4b9169ae8612

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Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor

Autor: J-D Gallezot, Eric L. Stangeland, Richard E. Carson, Khs Kim, Jacqueline A.M. Smith, ST Patil, William J. Martin, DL Patil, S Kshirsagar, Wendol Williams, OT Daniels, Glenmar P. Obedencio, Y-S. Ding, Shannan Henry, PR Tsuruda

Publikováno v: International Journal of Neuropsychopharmacology

Background Monoamine reuptake inhibitors exhibit unique clinical profiles that reflect distinct engagement of the central nervous system (CNS) transporters. Methods We used a translational strategy, including rodent pharmacokinetic/pharmacodynamic mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39d98640151d1678b20a9f62b1076c8
https://doi.org/10.1093/ijnp/pyu027

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Total Synthesis of Caerulomycin C via the Halogen Dance Reaction

Autor: Tarek Sammakia, Mark C. Whitcomb, Eric L. Stangeland

Publikováno v: Organic Letters. 4:2385-2388

[reaction: see text] The total synthesis of caerulomycin C is described. Key steps in this synthesis utilize 1,2-, 1,3-, and 1,4-halogen dance reactions for the functionalization of the pyridine ring.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dab43d57e601a15892148e2ffab75ae
https://doi.org/10.1021/ol026135m

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New chiral ligands for the asymmetric copper catalyzed conjugate addition of Grignard reagents to enones

Autor: Eric L. Stangeland, Tarek Sammakia

Publikováno v: Tetrahedron. 53:16503-16510

The copper catalyzed conjugate addition of n-butyl Grignard to enones in the presence of chiral ferrocenyl phosphine oxazoline ligands has been studied and found to provide useful levels of asymmetric induction. A comparison of the ferrocene derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5787d8e3531b62bc5eb7251049c3f41e
https://doi.org/10.1016/s0040-4020(97)01031-4

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Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

Autor: Alexander McNamara, Mathai Mammen, William J. Martin, Sharath S. Hegde, Eric L. Stangeland, MT Pulido-Rios, Tod Steinfeld

Publikováno v: Pulmonary pharmacologytherapeutics. 25(5)

Combinations of a muscarinic receptor antagonist (MA) and a β(2)-adrenoceptor agonist (BA) improve bronchodilation in COPD patients to a greater extent than drugs with either mechanism alone. Here, using an in vivo model of bronchoprotection in guin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d80e094f24ab8705495a6ac0ce3e75
https://pubmed.ncbi.nlm.nih.gov/22766316

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Lithium aluminum hydride-N-methylpyrrolidine complex. 1. Synthesis and reactivity of lithium aluminum hydride-N-methyplyrrolidine complex. An air and thermally stable reducing agent derived from lithium aluminum hydride

Autor: Eric L. Stangeland, Thomas C. Jackson, Joseph C. Fuller, Bakthan Singaram

Publikováno v: Tetrahedron Letters. 35:1515-1518

A 1:1 lithium aluminum hydride-N-methylpyrrolidine complex (LAHNMP), obtained by the reaction of lithium aluminum hydride with N-methylpyrrolidine, is a powerful reducing agent, comparable to lithium aluminum hydride in its reducing properties. LAHNM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c83bd9d00a736a793197410f2c6d6576
https://doi.org/10.1016/s0040-4039(00)76746-3

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Aminoborohydrides. 2. Regiospecific reductions of α, β-unsaturated carbonyl compounds with lithium pyrrolidinoborohydride. A facile conversion of α, β-unsaturated aldehydes and ketones to the corresponding allylic alcohols in high purity

Autor: Joseph C. Fuller, Bakthan Singaram, Eric L. Stangeland, C. T. Goralski

Publikováno v: Tetrahedron Letters. 34:257-260

Lithium aminoborohydrides (LiABH3), obtained by the reaction of n-BuLi with amine-boranes, are powerful reducing agents for the reduction α, β-unsaturated aldehydes and ketones to the corresponding allylic alcohols. Thus, lithium pyrrolidinoborohyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a842d0e4afb939fa97a7e3567fb2aee
https://doi.org/10.1016/s0040-4039(00)60561-0

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