Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Eric L Van Nostrand"'
Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans.
Publikováno v:
PLoS Genetics, Vol 12, Iss 4, p e1005956 (2016)
To understand the molecular processes underlying aging, we screened modENCODE ChIP-seq data to identify transcription factors that bind to age-regulated genes in C. elegans. The most significant hit was the GATA transcription factor encoded by elt-2,
Externí odkaz:
https://doaj.org/article/96798d3d795840328d6a650b02344878
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005734 (2015)
Human kidney function declines with age, accompanied by stereotyped changes in gene expression and histopathology, but the mechanisms underlying these changes are largely unknown. To identify potential regulators of kidney aging, we compared age-asso
Externí odkaz:
https://doaj.org/article/d10e927a70444cf09165dbd5fb4222f3
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003325 (2013)
The normal aging process is associated with stereotyped changes in gene expression, but the regulators responsible for these age-dependent changes are poorly understood. Using a novel genomics approach, we identified HOX co-factor unc-62 (Homothorax)
Externí odkaz:
https://doaj.org/article/f783843de7094c4895ebf14d3027db8d
Publikováno v:
PLoS Genetics, Vol 3, Iss 5, p e85 (2007)
Knowledge of the functional cis-regulatory elements that regulate constitutive and alternative pre-mRNA splicing is fundamental for biology and medicine. Here we undertook a genome-wide comparative genomics approach using available mammalian genomes
Externí odkaz:
https://doaj.org/article/3e7e352d28154e89a1e2b966e1b76a26
Autor:
An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu, Julian A. Gingold, Ying Liu, Dandan Zhu, Chian-Shiu Chien, Wei-Chen Wang, Zian Liao, Fei Yuan, Chih-Wei Hsu, Jian Tu, Yao Yu, Taylor Rosen, Feng Xiong, Peilin Jia, Yi-Ping Yang, Danielle A. Bazer, Ya-Wen Chen, Wenbo Li, Chad D. Huff, Jay-Jiguang Zhu, Francesca Aguilo, Shih-Hwa Chiou, Nathan C. Boles, Chien-Chen Lai, Mien-Chie Hung, Zhongming Zhao, Eric L. Van Nostrand, Ruiying Zhao, Dung-Fang Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 upr
Externí odkaz:
https://doaj.org/article/e94f230ab56e49dfb83c91e1ccf71c9f
Autor:
Waqar Arif, Bhoomika Mathur, Michael F. Saikali, Ullas V. Chembazhi, Katelyn Toohill, You Jin Song, Qinyu Hao, Saman Karimi, Steven M. Blue, Brian A. Yee, Eric L. Van Nostrand, Sushant Bangru, Grace Guzman, Gene W. Yeo, Kannanganattu V. Prasanth, Sayeepriyadarshini Anakk, Carolyn L. Cummins, Auinash Kalsotra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Nonalcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease with complex pathogenic mechanisms. Here, the authors report that SRSF1 deficiency in mice livers provokes deleterious R-loop formation and genotoxicity, which impedes hep
Externí odkaz:
https://doaj.org/article/ee830a8f79654480908b12970aefaf07
Autor:
Louis Philip Benoit Bouvrette, Xiaofeng Wang, Jonathan Boulais, Jian Kong, Easin Uddin Syed, Steven M Blue, Lijun Zhan, Sara Olson, Rebecca Stanton, Xintao Wei, Brian Yee, Eric L Van Nostrand, Xiang-Dong Fu, Christopher B Burge, Brenton R Graveley, Gene W Yeo, Eric Lécuyer
Publikováno v:
Nucleic Acids Research. 51:D1549-D1557
RNA binding proteins (RBPs) are central regulators of gene expression implicated in all facets of RNA metabolism. As such, they play key roles in cellular physiology and disease etiology. Since different steps of post-transcriptional gene expression
Autor:
Trey Ideker, J. Silvio Gutkind, Gene W. Yeo, Scott M. Lippman, Jason F. Kreisberg, Emily Wheeler, Yan Song, Eric L. Van Nostrand, Christopher DeBoever, Xingyu Wu, Kathleen M. Fisch, James Jensen, Andrew M. Gross, Matan Hofree, Rachel Marty, Hannah Carter
Supplementary Table 1. Loci associated with tumor site of origin. Supplementary Table 2. GWAS Cancer Associations Re-tested in TCGA. Supplementary Table 3. Loci associated with somatic status of a cancer gene. Supplementary Table 4. TCGA Samples used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32528cf3228239f41aab38da8ea5ffb8
https://doi.org/10.1158/2159-8290.22531589.v1
https://doi.org/10.1158/2159-8290.22531589.v1
Autor:
Trey Ideker, J. Silvio Gutkind, Gene W. Yeo, Scott M. Lippman, Jason F. Kreisberg, Emily Wheeler, Yan Song, Eric L. Van Nostrand, Christopher DeBoever, Xingyu Wu, Kathleen M. Fisch, James Jensen, Andrew M. Gross, Matan Hofree, Rachel Marty, Hannah Carter
Supplementary Figure S1. Description of the TCGA data. Supplementary Figure S2. Flow chart describing data preprocessing, association testing and validation testing stages of the study. Supplementary Figure S3. QQ-plots and genomic inflation (G.I.) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017d566ae8e2696f5daa52d86fd5949d
https://doi.org/10.1158/2159-8290.22531592
https://doi.org/10.1158/2159-8290.22531592
Autor:
Trey Ideker, J. Silvio Gutkind, Gene W. Yeo, Scott M. Lippman, Jason F. Kreisberg, Emily Wheeler, Yan Song, Eric L. Van Nostrand, Christopher DeBoever, Xingyu Wu, Kathleen M. Fisch, James Jensen, Andrew M. Gross, Matan Hofree, Rachel Marty, Hannah Carter
Supplementary Figure, Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01808133e65fdc3002e643b5991979fd
https://doi.org/10.1158/2159-8290.22531595.v1
https://doi.org/10.1158/2159-8290.22531595.v1