Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Eric L Van Nostrand"'
Autor:
An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu, Julian A. Gingold, Ying Liu, Dandan Zhu, Chian-Shiu Chien, Wei-Chen Wang, Zian Liao, Fei Yuan, Chih-Wei Hsu, Jian Tu, Yao Yu, Taylor Rosen, Feng Xiong, Peilin Jia, Yi-Ping Yang, Danielle A. Bazer, Ya-Wen Chen, Wenbo Li, Chad D. Huff, Jay-Jiguang Zhu, Francesca Aguilo, Shih-Hwa Chiou, Nathan C. Boles, Chien-Chen Lai, Mien-Chie Hung, Zhongming Zhao, Eric L. Van Nostrand, Ruiying Zhao, Dung-Fang Lee
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 upr
Externí odkaz:
https://doaj.org/article/e94f230ab56e49dfb83c91e1ccf71c9f
Autor:
Waqar Arif, Bhoomika Mathur, Michael F. Saikali, Ullas V. Chembazhi, Katelyn Toohill, You Jin Song, Qinyu Hao, Saman Karimi, Steven M. Blue, Brian A. Yee, Eric L. Van Nostrand, Sushant Bangru, Grace Guzman, Gene W. Yeo, Kannanganattu V. Prasanth, Sayeepriyadarshini Anakk, Carolyn L. Cummins, Auinash Kalsotra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Nonalcoholic steatohepatitis (NASH) is an advanced form of fatty liver disease with complex pathogenic mechanisms. Here, the authors report that SRSF1 deficiency in mice livers provokes deleterious R-loop formation and genotoxicity, which impedes hep
Externí odkaz:
https://doaj.org/article/ee830a8f79654480908b12970aefaf07
Autor:
Gabriela Krivdova, Veronique Voisin, Erwin M. Schoof, Sajid A. Marhon, Alex Murison, Jessica L. McLeod, Martino M. Gabra, Andy G.X. Zeng, Stefan Aigner, Brian A. Yee, Alexander A. Shishkin, Eric L. Van Nostrand, Karin G. Hermans, Aaron C. Trotman-Grant, Nathan Mbong, James A. Kennedy, Olga I. Gan, Elvin Wagenblast, Daniel D. De Carvalho, Leonardo Salmena, Mark D. Minden, Gary D. Bader, Gene W. Yeo, John E. Dick, Eric R. Lechman
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110481- (2022)
Summary: Gene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells (HSCs) point to shared core stemness properties. However, discordance between mRNA and protein signatures highlights an important role for post-
Externí odkaz:
https://doaj.org/article/939447993067409d9b5458011e74bcb6
Autor:
Eric L. Van Nostrand, Gabriel A. Pratt, Brian A. Yee, Emily C. Wheeler, Steven M. Blue, Jasmine Mueller, Samuel S. Park, Keri E. Garcia, Chelsea Gelboin-Burkhart, Thai B. Nguyen, Ines Rabano, Rebecca Stanton, Balaji Sundararaman, Ruth Wang, Xiang-Dong Fu, Brenton R. Graveley, Gene W. Yeo
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-26 (2020)
Abstract Background A critical step in uncovering rules of RNA processing is to study the in vivo regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation (CLIP) methods enable mapping RBP targets transcriptome-wide, b
Externí odkaz:
https://doaj.org/article/7bd753fbac7546c7ad4fb5a7375a17e9
Autor:
Roger P. Alexander, Robert R Kitchen, Juan Pablo Tosar, Matthew Roth, Pieter Mestdagh, Klaas E. A. Max, Joel Rozowsky, Karolina Elżbieta Kaczor-Urbanowicz, Justin Chang, Leonora Balaj, Bojan Losic, Eric L. Van Nostrand, Emily LaPlante, Bogdan Mateescu, Brian S. White, Rongshan Yu, Aleksander Milosavljevic, Gustavo Stolovitzky, Ryan M. Spengler
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These extracellular RNA (exRNA) play a role in intercellular signaling, serve as biomarkers of d
Externí odkaz:
https://doaj.org/article/d4209b9f34794e26b87ce77d73536889
Autor:
Ei-Wen Yang, Jae Hoon Bahn, Esther Yun-Hua Hsiao, Boon Xin Tan, Yiwei Sun, Ting Fu, Bo Zhou, Eric L. Van Nostrand, Gabriel A. Pratt, Peter Freese, Xintao Wei, Giovanni Quinones-Valdez, Alexander E. Urban, Brenton R. Graveley, Christopher B. Burge, Gene W. Yeo, Xinshu Xiao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Differential binding of RNA-binding proteins mediated by genetic variants (GVs) can influence posttranscriptional regulation. Here, the authors develop BEAPR, a computational approach to identify allele-specific binding events in eCLIP-Seq data.
Externí odkaz:
https://doaj.org/article/40fe4f1d191643449b3e71a16d4eeda4
Autor:
Louis Philip Benoit Bouvrette, Xiaofeng Wang, Jonathan Boulais, Jian Kong, Easin Uddin Syed, Steven M Blue, Lijun Zhan, Sara Olson, Rebecca Stanton, Xintao Wei, Brian Yee, Eric L Van Nostrand, Xiang-Dong Fu, Christopher B Burge, Brenton R Graveley, Gene W Yeo, Eric Lécuyer
Publikováno v:
Nucleic Acids Research. 51:D1549-D1557
RNA binding proteins (RBPs) are central regulators of gene expression implicated in all facets of RNA metabolism. As such, they play key roles in cellular physiology and disease etiology. Since different steps of post-transcriptional gene expression
Autor:
Trey Ideker, J. Silvio Gutkind, Gene W. Yeo, Scott M. Lippman, Jason F. Kreisberg, Emily Wheeler, Yan Song, Eric L. Van Nostrand, Christopher DeBoever, Xingyu Wu, Kathleen M. Fisch, James Jensen, Andrew M. Gross, Matan Hofree, Rachel Marty, Hannah Carter
Supplementary Table 1. Loci associated with tumor site of origin. Supplementary Table 2. GWAS Cancer Associations Re-tested in TCGA. Supplementary Table 3. Loci associated with somatic status of a cancer gene. Supplementary Table 4. TCGA Samples used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32528cf3228239f41aab38da8ea5ffb8
https://doi.org/10.1158/2159-8290.22531589.v1
https://doi.org/10.1158/2159-8290.22531589.v1
Autor:
Trey Ideker, J. Silvio Gutkind, Gene W. Yeo, Scott M. Lippman, Jason F. Kreisberg, Emily Wheeler, Yan Song, Eric L. Van Nostrand, Christopher DeBoever, Xingyu Wu, Kathleen M. Fisch, James Jensen, Andrew M. Gross, Matan Hofree, Rachel Marty, Hannah Carter
Supplementary Figure S1. Description of the TCGA data. Supplementary Figure S2. Flow chart describing data preprocessing, association testing and validation testing stages of the study. Supplementary Figure S3. QQ-plots and genomic inflation (G.I.) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017d566ae8e2696f5daa52d86fd5949d
https://doi.org/10.1158/2159-8290.22531592
https://doi.org/10.1158/2159-8290.22531592
Autor:
Trey Ideker, J. Silvio Gutkind, Gene W. Yeo, Scott M. Lippman, Jason F. Kreisberg, Emily Wheeler, Yan Song, Eric L. Van Nostrand, Christopher DeBoever, Xingyu Wu, Kathleen M. Fisch, James Jensen, Andrew M. Gross, Matan Hofree, Rachel Marty, Hannah Carter
Supplementary Figure, Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01808133e65fdc3002e643b5991979fd
https://doi.org/10.1158/2159-8290.22531595.v1
https://doi.org/10.1158/2159-8290.22531595.v1