Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Eric L Harshfield"'
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Akademický článek
Cerebrovascular Disorders
Autor: Alessandra Granata, Eric L Harshfield, Joseph V Moxon
Publikováno v: BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-3 (2023)
Abstract Cerebrovascular disorders pose a global health concern. Advances in basic and clinical research, including induced pluripotent stem cell models and multi-omic approaches, have improved our understanding and management of these disorders. How
Externí odkaz: https://doaj.org/article/c4ad12ae5c66414fa3fd0fe2d63451a8
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4
Both vascular risk factors and common genetic variants influence penetrance of variants causing monogenic stroke
Autor: Bernard PH Cho, Eric L Harshfield, Maha Al-Thani, Daniel J Tozer, Steven Bell, Hugh S Markus
Monogenic forms of stroke have been thought to be rare with high penetrance. However, recent studies have reported typical monogenic stroke pathogenic variants are much commoner than expected in the general population. Whether such variants are assoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2c9eec2eac64fd268925fcd19093ae2
https://doi.org/10.1101/2022.05.24.22275509
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Metabolic associations with stroke, dementia, and imaging markers of cerebral small vessel disease: a comprehensive metabolomics study
Autor: Eric L Harshfield, Hugh S Markus
BackgroundCerebral small vessel disease is a major cause of ischemic stroke and vascular dementia, which are among the leading causes of death and disability worldwide. Metabolomics can help identify novel risk factors to better understand pathogenes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dfd8c3ca4a37b7efc59fe744c97a6ca
https://doi.org/10.1101/2022.03.24.22272911
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7
Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomization study
Autor: Joel T. Gibson, Hugh S. Markus, Eric L. Harshfield, Steven Bell
Publikováno v: Atherosclerosis
Background and aims Observational studies have reported an association between periodontitis and cardiovascular disease but whether this association is causal is uncertain. We therefore used Mendelian randomization to test whether periodontitis is ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fc05602831e04bc65a3fd29f4c14e5
http://europepmc.org/articles/PMC7660116
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NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants
Autor: D Tozer, Hugh S. Markus, Steven Bell, Stefania Nannoni, Stefan Gräf, Eric L. Harshfield, Bernard P H Cho
Publikováno v: Journal of Neurology, Neurosurgery, and Psychiatry
BackgroundCysteine-altering NOTCH3 variants identical to those causing the rare monogenic form of stroke, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), have been reported more common than expect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8c4f4a934c4190e398c3b473951842
https://www.repository.cam.ac.uk/handle/1810/318884
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Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study
Autor: Eric L. Harshfield, Claudia Langenberg, Marios K. Georgakis, Rainer Malik, Nora Franceschini, Hugh S. Markus, Nicholas J. Wareham, Martin Dichgans
Publikováno v: Neurology
Neurology 96(13), e1732-e1742 (2021). doi:10.1212/WNL.0000000000011555
medRxiv
RationaleType 2 diabetes mellitus (T2D) is an established risk factor for cerebrovascular disease but the mechanisms underlying this association remain elusive. Disentangling the causal effects of T2D, hyperglycemia, and pre-diabetic phenotypes (insu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec726c2aae70696f78a316ee79c1810
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10
Metabolomic profiling in small vessel disease identifies multiple associations with disease severity
Autor: Eric L. Harshfield, Hugh S. Markus, Tuladhar Am, Matthew R. Lewis, Caroline Sands, de Leeuw F
Publikováno v: medRxiv
Brain, 145, 2461-2471
Brain, 145, 7, pp. 2461-2471
Cerebral small vessel disease (SVD) is a major cause of vascular cognitive impairment and dementia. There are few treatments, largely reflecting limited understanding of the underlying pathophysiology. Metabolomics can be used to identify novel risk
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f749e82b78fcce03a599e2dc3b65069c
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