Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune GastritisSummary

Autor: Kevin A. Bockerstett, Christine P. Petersen, Christine N. Noto, Lindsey M. Kuehm, Chun Fung Wong, Eric L. Ford, Ryan M. Teague, Jason C. Mills, James R. Goldenring, Richard J. DiPaolo

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 561-579 (2020)

Background & Aims: The association between chronic inflammation and gastric carcinogenesis is well established, but it is not clear how immune cells and cytokines regulate this process. We investigated the role of interleukin 27 (IL27) in the develop

Externí odkaz: https://doaj.org/article/a9b943789971460984bc215b4cf4f29f

Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune Gastritis

Autor: Christine P. Petersen, Kevin A. Bockerstett, Richard J. DiPaolo, Christine N. Noto, Ryan M. Teague, Lindsey M. Kuehm, Eric L. Ford, Jason C. Mills, James R. Goldenring, Chun Fung Wong

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 561-579 (2020)

Background & Aims The association between chronic inflammation and gastric carcinogenesis is well established, but it is not clear how immune cells and cytokines regulate this process. We investigated the role of interleukin 27 (IL27) in the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5944bc3c0b7785e1a2d843431f7bb28f
http://europepmc.org/articles/PMC7399182

Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia

Autor: Richard J. DiPaolo, Chun F Wong, Kevin A. Bockerstett, Jason C. Mills, Luciana H. Osaki, Blair B. Madison, Eric L. Ford

Publikováno v: The Journal of Pathology. 247:513-523

Chronic inflammation of the gastric mucosa, often caused by autoimmune gastritis and/or infection with Helicobacter pylori, can lead to atrophy of acid-secreting parietal cells with metaplasia of remaining cells. The histological pattern marks a crit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff6eb23625827c307ef1cad00dc5888d
https://doi.org/10.1002/path.5214

Single-Cell Transcriptional Analyses Identify Lineage-Specific Epithelial Responses to Inflammation and Metaplastic Development in the Gastric Corpus

Autor: Christine N. Noto, Kevin A. Bockerstett, Jason C. Mills, Richard J. DiPaolo, Jose B. Saenz, Nicholas M. Jackson, Tae-Hyuk Ahn, Eric L. Ford, Scott A. Lewis

Publikováno v: Gastroenterology

Background & Aims Chronic atrophic gastritis can lead to gastric metaplasia and increase risk of gastric adenocarcinoma. Metaplasia is a precancerous lesion associated with an increased risk for carcinogenesis, but the mechanism(s) by which inflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cd78fc3a3af6005c358ce6f01e609a
https://doi.org/10.1053/j.gastro.2020.08.027

IL-13 promotes precancerous epithelial cell changes during autoimmune gastritis

Autor: Christine N Noto, Kevin A Bockerstett, Nicholas M Jackson, Eric L Ford, Richard J DiPaolo

Publikováno v: The Journal of Immunology. 204:221.5-221.5

Individuals with chronic autoimmune diseases have an increased risk of cancer development in the affected organ. Cytokines released during chronic inflammation regulate tissue repair processes and can contribute to an increased risk of carcinogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad654ed5fc068dedb49ee14c0b98a6c7
https://doi.org/10.4049/jimmunol.204.supp.221.5