Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed CellsSummary

Autor: Nicolai Lehnert, Dhiman Maitra, Stephen W. Ragsdale, Laure Rittié, M. Bishr Omary, Alexey I. Nesvizhskii, Haoming Zhang, Matthew W. Wolf, Harald Herrmann, Venkatesha Basrur, Rani Richardson, Yoichi Osawa, Eric L. Carter

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 4, Pp 659-682.e1 (2019)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Porphyrias are caused by porphyrin accumulation resulting from defects in the heme biosynthetic pathway that typically lead to photosensitivity and possible end-stage liver disease with an increased risk of hepatocellular carcinoma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0592cf3cff3ae349fa52696e431bb166
http://www.sciencedirect.com/science/article/pii/S2352345X19300724

Ferric Heme as a CO/NO Sensor in the Nuclear Receptor Reverbβ by Coupling Gas binding to Electron Transfer

Autor: Jill B. Harland, Amy L. Speelman, Nicolai Lehnert, Stephen W. Ragsdale, Anindita Sarkar, Eric L. Carter

Rev-Erbβ is a nuclear receptor that couples circadian rhythm, metabolism, and inflammation.1-7Heme binding to the protein modulates its function as a repressor, its stability, its ability to bind other proteins, and its activity in gas sensing.8-11R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af53eaeb2e296ade329bff080afe893b
https://doi.org/10.1101/2020.06.22.164806

High Affinity Heme Binding to a Heme Regulatory Motif on the Nuclear Receptor Rev-erbβ Leads to Its Degradation and Indirectly Regulates Its Interaction with Nuclear Receptor Corepressor

Autor: Nirupama Gupta, Stephen W. Ragsdale, Eric L. Carter

Publikováno v: Journal of Biological Chemistry. 291:2196-2222

Rev-erbα and Rev-erbβ are heme-binding nuclear receptors (NR) that repress the transcription of genes involved in regulating metabolism, inflammation, and the circadian clock. Previous gene expression and co-immunoprecipitation studies led to a mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188c687a3294cd4c7526cac3957bc974
https://doi.org/10.1074/jbc.m115.670281

Apoprotein isolation and activation, and vibrational structure of the Helicobacter mustelae iron urease

Autor: Denis A. Proshlyakov, Eric L. Carter, Robert P. Hausinger

Publikováno v: Journal of Inorganic Biochemistry. 111:195-202

The micro aerophilic pathogen Helicobacter mustelae synthesizes an oxygen-labile, iron-containing urease (UreA2B2) in addition to its standard nickel-containing enzyme (UreAB). An apoprotein form of the iron urease was prepared from ureA2B2-expressin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48c3b4bf64edffb01704d750bd12b16
https://doi.org/10.1016/j.jinorgbio.2011.10.016

A Randomized, Double-Blind Comparison of Two Topical Anesthesic Formulations Prior to Electrodesiccation of Dermatosis Papulosa Nigra

Autor: Carol A. Coppola, Eric L. Carter, Franco A. Barsanti

Publikováno v: Dermatologic Surgery. 32:1-6

BACKGROUNDLiposomal lidocaine 4% (L.M.X.4 cream, Ferndale Laboratories Inc., Ferndale, MI, USA) has been proposed as a more rapidly acting topical anesthetic than the eutectic mixture of lidocaine 2.5% and prilocaine 2.5% (EMLA cream, AstraZeneca LP,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa454ad5c22a23f4acc99f9440959ff4
https://doi.org/10.1111/1524-4725.2006.32000